<i>Radioactive Indicators</i>

Hevesy, G.; Irvine, John W.

doi:10.1063/1.3066397

Cited by 26 publications

(33 citation statements)

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“…However, in various clinical situations such as diarrhoea, diabetic acidosis, familial periodic paralysis, post-operative states, etc., where intra-cellular deficiency of potassium is seen, erythrocyte po tassium has also been shown to be depressed [ 11]. The significant relationship between predialysis TBK and erythrocyte po tassium and also the parallel changes in the two parameters strongly suggest that erythrocytes reflect reliably the direction and magnitude of change in T BK .…”

Section: Discussionmentioning

confidence: 93%

Studies on Total Body, Serum and Erythrocyte Potassium in Patients on Maintenance Haemodialysis. The Value of Erythrocyte Potassium as a Measure of Body Potassium

Johny

Lawrence

O'Halloran

et al. 1970

Nephron

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Total body, Erythrocyte and Serum potassium changes during haemodialysis were studied on 29 occasions in 15 patients on maintenance dialysis with a low dialysate potassium concentration (1 mEq/l). The loss in total body potassium during haemodialysis (measured with a whole body counter) varied widely and was significantly related to the pre-dialysis body potassium state of the patient as assessed by total body potassium per kg body weight in spite of a constant high serum to dialysate concentration gradient in all patients. Serum potassium levels did not correlate well with changes in total body potassium or erythrocyte potassium. Erythrocyte potassium was shown to be a reliable and useful index of the direction and magnitude of changes in total body potassium during haemodialysis.

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Section: Discussionmentioning

confidence: 93%

Studies on Total Body, Serum and Erythrocyte Potassium in Patients on Maintenance Haemodialysis. The Value of Erythrocyte Potassium as a Measure of Body Potassium

Johny

Lawrence

O'Halloran

et al. 1970

Nephron

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“…The list of possible interfering isotopes given in Table 2 Determinations of Br by activation analysis did not give satisfactory results, owing to the difficulty of precipitating AgBr without contamination by other R. D. KEYNES AND P. R. LEWIS isotopes. It seems likely, however, that the ratio of bromine to chlorine in the axons will be roughly the same as in sea water, since there is no evidence of any marked discrimination between the two elements in marine animals (Krogh, 1939), and tracer studies have shown the distribution of bromide and chloride between tissue and serum to be very similar (Hevesy, 1948). On this basis Br82 might cause a maximum error of 1 % in the apparent sodium content of Sepia axons or whole nerve trunks-a figure not inconsistent with the estimate of 0-5 % from the decay curve given in Fig.…”

Section: R D Keynes and P R Lewis Resultsmentioning

confidence: 99%

The sodium and potassium content of cephalopod nerve fibres

Keynes¹,

Lewis²

1951

The Journal of Physiology

209

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“…The study was then extended to include simultaneous determinations on the inorganic and lipide fractions of the plasma, so that the isotopic concentration in the lipides could be expressed as a function of the concentration of the inorganic phosphate-"relative specific activity" (6).…”

mentioning

confidence: 99%

The Effects of Lipotropic Factors on Phospholipide Turnover in the Plasma of Normal Persons as Indicated by Radioactive Phosphorus 1

Cornatzer¹,

Cayer²

1950

J. Clin. Invest.

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The action of choline and methionine in preventing or curing the fatty infiltration of the liver which is produced experimentally in animals by low protein diets is believed to result from an increased turnover of phospholipides in the liver (1, 2). Since this organ is the main, if not the sole, source of phospholipides in plasma (3), it would seem that changes in the formation of phospholipides in the liver would be reflected by corresponding changes in the amounts of newly formed phospholipides in the plasma (4). No methods were available for the determination of newly formed plasma phospholipides until isotopic techniques were developed and radioactive tracers became available.It is now possible to study the formation of plasma phospholipides following the administration of radioactive phosphorus, and to obtain an indication of the turnover of these compounds in the liver. Few data of this sort are available for human subjects, however. Hence, it became necessary to estimate the turnover in normal persons, before the effects of lipotropic agents such as choline and methionine could be investigated and information could be obtained on the mode of action and possible therapeutic application of these substances.Preliminary experiments to determine the validity of the method for determining the radioactivity and phosphorus of the plasma lipides in persons with and without liver disease were done and the results obtained were used to calculate the turnover of phospholipides (specific activity) (5).

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Radioactive Indicators

Cited by 26 publications

References 0 publications

Studies on Total Body, Serum and Erythrocyte Potassium in Patients on Maintenance Haemodialysis. The Value of Erythrocyte Potassium as a Measure of Body Potassium

Studies on Total Body, Serum and Erythrocyte Potassium in Patients on Maintenance Haemodialysis. The Value of Erythrocyte Potassium as a Measure of Body Potassium

The sodium and potassium content of cephalopod nerve fibres

The Effects of Lipotropic Factors on Phospholipide Turnover in the Plasma of Normal Persons as Indicated by Radioactive Phosphorus 1

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