Psuedomonas aeruginosa-Associated Acute and Chronic Pulmonary Infections

Abstract

Pseudomonas aeruginosa is highly successful in colonizing in all types of environments. P. aeruginosa colonizing in adverse environment due to the presence of its virulence factors include production of toxins, proteases hemolysins, and formation of biofilms. In man, the most common opportunist pathogen is P. aeruginosa. Metabolically P. aeruginosa is versatile. Most of the antibiotics targeted metabolically active cells and bacteria could contribute to decrease in biofilm susceptibility to the antimicrobial agents. Scientists suggested about Pseudomonas that it can be catabolized any hydrocarbon in specific time along with availability of oxygen and nitrite. If bacteria are not susceptible to one agent in three or more, it is called as multidrug-resistance strains. The antimicrobial treatments were not suitable when microorganism presented in vitro microorganism resistance to antimicrobials used for treatment of the patient which lack of treatment for 24 h after diagnosis of microbial infections. Bacteria have developed resistance against commonly used antibiotics. Treatment of Pseudomonas infections is coming harder day by day as its resistance against most of the antibiotics. Because of resistance of bacteria antibiotics, alternative methods are in consideration. These methods include use of lactic acid bacteria (LAB) and most recently nano-particles. That is why they are used as antibacterial agents.

Evaluation of Efflux-Mediated Resistance and Biofilm formation in Virulent Pseudomonas aeruginosa Associated with Healthcare Infections

“…Hemolysin production further suggests impending disease severity by forming cellular pore and necrotic cell death. As host cell lysis increases, there is increase in erythrocytes depletion, cytotoxicity, host cell plasma membrane fluidity, bilayer structure deformities resulting to immune evasion, physiological imbalance and septic shock mostly in severe conditions [ 29 ]. These virulence factors contribute to several stages of tissue damage that involve adherence, colonization and invasion leading to local and systemic dissemination of biofilm lipopolysaccharide, polysaccharide slime (alginate), hemolysin, and proteases [ 29 ].…”

A Blockchain-Based Scalability Solution with Microgrids Peer-to-Peer Trade

“…Over the past decade, Distributed Energy Resources (DER) have experienced a substantial global proliferation [1][2][3][4]. These resources have revolutionized the dynamics of energy generation and distribution within the energy sector by enabling consumers and prosumers (individuals who both generate and consume electricity) to engage in direct energy sharing without the necessity of intermediaries.…”