<i>Porphyromonas gingivalis</i> exacerbates alcoholic liver disease by altering gut microbiota composition and host immune response in mice

Gao, Yuting; Zhang, Peng; Wei, Yi‐Ming; Ye, C; Mao, Daqing; Xia, Dasheng; Luo, Yi

doi:10.1111/jcpe.13833

Cited by 8 publications

(3 citation statements)

References 48 publications

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“…The KEGG enrichment analysis revealed that these crosstalk genes are involved in ALD, the complement and clotting cascade, NF-κB signaling pathway, and Toll-like receptor signaling pathways. Studies have indicated that P. gingivalis can worsen ALD by changing the composition of intestinal microbiota and the immune response of the host [ 20 ]. Moreover, ALD has an increased risk of MS development [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Exploration of potential shared gene signatures between periodontitis and multiple sclerosis

Wu,

Cheng,

Zhang

et al. 2024

BMC Oral Health

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Background Although periodontitis has previously been reported to be linked with multiple sclerosis (MS), but the molecular mechanisms and pathological interactions between the two remain unclear. This study aims to explore potential crosstalk genes and pathways between periodontitis and MS. Methods Periodontitis and MS data were obtained from the Gene Expression Omnibus (GEO) database. Shared genes were identified by differential expression analysis and weighted gene co-expression network analysis (WGCNA). Then, enrichment analysis for the shared genes was carried out by multiple methods. The least absolute shrinkage and selection operator (LASSO) regression was used to obtain potential shared diagnostic genes. Furthermore, the expression profile of 28 immune cells in periodontitis and MS was examined using single-sample GSEA (ssGSEA). Finally, real-time quantitative fluorescent PCR (qRT-PCR) and immune histochemical staining were employed to validate Hub gene expressions in periodontitis and MS samples. Results FAM46C, SLC7A7, LY96, CFI, DDIT4L, CD14, C5AR1, and IGJ genes were the shared genes between periodontitis, and MS. GO analysis revealed that the shared genes exhibited the greatest enrichment in response to molecules of bacterial origin. LASSO analysis indicated that CFI, DDIT4L, and FAM46C were the most effective shared diagnostic biomarkers for periodontitis and MS, which were further validated by qPCR and immunohistochemical staining. ssGSEA analysis revealed that T and B cells significantly influence the development of MS and periodontitis. Conclusions FAM46C, SLC7A7, LY96, CFI, DDIT4L, CD14, C5AR1, and IGJ were the most important crosstalk genes between periodontitis, and MS. Further studies found that CFI, DDIT4L, and FAM46C were potential biomarkers in periodontitis and MS.

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Section: Discussionmentioning

confidence: 99%

Exploration of potential shared gene signatures between periodontitis and multiple sclerosis

Wu,

Cheng,

Zhang

et al. 2024

BMC Oral Health

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“…Moreover, we learned that intestinal permeability and LPS were significantly increased in alcohol-dependent subjects at the onset of withdrawal, suggesting that the gut-liver axis plays an important role in the pathogenesis of alcohol dependence ( Leclercq et al, 2012 ). Gao et al (2023) showed that oral administration of Porphyromonas gingivalis worsened hepatic inflammation in ALD mice by increasing the protein expression of Toll-like receptor 4 (TLR4) and p65, increasing the mRNA expression of IL-6 and TNF-α and up-regulating the production of Transforming Growth Factor β1 (TGF-β 1) and galactaglutinin-3 (Gal-3). Likewise, in alcoholic cirrhosis the intestinal flora remains altered and translocated toward the liver and ascites ( Oesterreicher et al, 1995 ; Naseri et al, 2021 ).…”

Section: Fatty Liver Disease and Gut-liver Axismentioning

confidence: 99%

The gut-liver axis in fatty liver disease: role played by natural products

Ming,

Ruishi,

Linyi

et al. 2024

Front. Pharmacol.

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Fatty liver disease, a condition characterized by fatty degeneration of the liver, mainly classified as non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD), has become a leading cause of cirrhosis, liver cancer and death. The gut-liver axis is the bidirectional relationship between the gut and its microbiota and its liver. The liver can communicate with the gut through the bile ducts, while the portal vein transports the products of the gut flora to the liver. The intestinal flora and its metabolites directly and indirectly regulate hepatic gene expression, leading to an imbalance in the gut-liver axis and thus contributing to the development of liver disease. Utilizing natural products for the prevention and treatment of various metabolic diseases is a prevalent practice, and it is anticipated to represent the forthcoming trend in the development of drugs for combating NAFLD/ALD. This paper discusses the mechanism of the enterohepatic axis in fatty liver, summarizes the important role of plant metabolites in natural products in fatty liver treatment by regulating the enterohepatic axis, and provides a theoretical basis for the subsequent development of new drugs and clinical research.

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“…Regrettably, the mechanism of its role in HCC remains to be further studied. Nevertheless, research has demonstrated a close association between oral microorganisms, specifically P. gingivalis, and the development of hepatitis and alcoholic liver disease (Gao et al, 2023). P. gingivalis is capable of inducing intestinal microbial dysbiosis and impairing the integrity of the intestinal mucosal barrier, thereby facilitating the migration of enterobacteriaceae to the liver (Nakajima et al, 2015).…”

Section: Hepatocellular Cancermentioning

confidence: 99%

The role of oral microbiota in cancer

Lan,

Liu,

Cui

et al. 2023

Front. Microbiol.

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Cancer remains a significant global challenge, with an estimated 47% increase in cancer patients from 2020 to 2040. Increasing research has identified microorganism as a risk factor for cancer development. The oral cavity, second only to the colon, harbors more than 700 bacterial species and serves as a crucial microbial habitat. Although numerous epidemiological studies have reported associations between oral microorganisms and major systemic tumors, the relationship between oral microorganisms and cancers remains largely unclear. Current research primarily focuses on respiratory and digestive system tumors due to their anatomical proximity to the oral cavity. The relevant mechanism research mainly involves 47% dominant oral microbial population that can be cultured in vitro. However, further exploration is necessary to elucidate the mechanisms underlying the association between oral microbiota and tumors. This review systematically summarizes the reported correlations between oral microbiota and common cancers while also outlining potential mechanisms that may guide biological tumor treatment.

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Porphyromonas gingivalis exacerbates alcoholic liver disease by altering gut microbiota composition and host immune response in mice

Cited by 8 publications

References 48 publications

Exploration of potential shared gene signatures between periodontitis and multiple sclerosis

Exploration of potential shared gene signatures between periodontitis and multiple sclerosis

The gut-liver axis in fatty liver disease: role played by natural products

The role of oral microbiota in cancer

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