<i>Porphyromonas gingivalis</i>and adverse pregnancy outcomes: a review on its intricate pathogenic mechanisms

Chopra, Aditi; Radhakrishnan, Raghu; Sharma, Mohit

doi:10.1080/1040841x.2020.1747392

Cited by 39 publications

(42 citation statements)

References 168 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The activation of complex signaling networks, for example, the HSP27/p21 pathway via p53/p38 and JNK, may also contribute to G1 arrest and cell apoptosis [ 94 ]. Other mechanisms have been proposed and summarized in detail previously, including P. gingivalis ’ persistence and survival within utero-placental tissues via sophisticated invasive strategies and immune response evasion, development of polymicrobial dysbiosis and synergy with other commensal bacteria to increase the overall microbial burden at the maternal–fetal interface, increased expression of acute-phase proteins such as CRP and pentraxin3, excessive generation of ROS, increased production of fetal adrenal cortisone, and fetal stress [ 7 ].…”

Section: Obstetricsmentioning

confidence: 99%

“…As the key etiological agent in periodontitis, Porphyromonas gingivalis ( P. gingivalis ) has proved to be closely correlated with the occurrence and development of many systemic diseases, such as atherosclerosis, cancer, and Alzheimer’s disease [ 2 , 3 , 4 ]. The roles of P. gingivalis in systemic diseases have been discussed for several years, and several reviews have summarized the effects and the inner mechanisms [ 5 , 6 , 7 , 8 , 9 , 10 ]. However, most of these articles only focus on the relationship between P. gingivalis and one specific disease or one class of diseases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Porphyromonas gingivalis and Its Systemic Impact: Current Status

et al. 2020

View full text Add to dashboard Cite

The relationship between periodontitis and systemic diseases, notably including atherosclerosis and diabetes, has been studied for several years. Porphyromonas gingivalis, a prominent component of oral microorganism communities, is the main pathogen that causes periodontitis. As a result of the extensive analysis of this organism, the evidence of its connection to systemic diseases has become more apparent over the last decade. A significant amount of research has explored the role of Porphyromonas gingivalis in atherosclerosis, Alzheimer’s disease, rheumatoid arthritis, diabetes, and adverse pregnancy outcomes, while relatively few studies have examined its contribution to respiratory diseases, nonalcoholic fatty liver disease, and depression. Here, we provide an overview of the current state of knowledge about Porphyromonas gingivalis and its systemic impact in an aim to inform readers of the existing epidemiological evidence and the most recent preclinical studies. Additionally, the possible mechanisms by which Porphyromonas gingivalis is involved in the onset or exacerbation of diseases, together with its effects on systemic health, are covered. Although a few results remain controversial, it is now evident that Porphyromonas gingivalis should be regarded as a modifiable factor for several diseases.

show abstract

Section: Obstetricsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Porphyromonas gingivalis and Its Systemic Impact: Current Status

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Causal infectious agents, the role of polymicrobial infections, critical sites of infection, as well as the participation of cells and activation pathways of the immune response have barely been identified (Cappelletti et al, 2016). Chopra et al (2020) based on the evidence, suggest the atopobiosis of P. gingivalis to the amniotic fluid and placenta of women with APO; however, the molecular mechanisms by which P. gingivalis relates to the occurrence of complications during pregnancy and in the newborn are not clear in the literature (Chopra et al, 2020). Some of the potential pathogenic mechanisms which might link P. gingivalis and APO include:…”

Section: Introductionmentioning

confidence: 99%

“…(1) Direct invasion, translocation, and injury to the foetalplacental unit/interface and maternal tissues, (2) Persistence and survival within the foetal and maternal tissues and immune response evasion, (3) Increased production of proinflammatory cytokines and shift in maternal-foetal immune response from Th2 to Th1 with the onset of Th17/T regulatory cell imbalance, (4) Activation of the acute-phase response, (5) Onset of Polymicrobial dysbiosis and development of pathobiont species, (6) Increased oxidative stress in the foetal and maternal tissue, and (7) Increased foetal adrenal cortisone production and the onset of foetal stress (Chopra et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Porphyromonas gingivalis Placental Atopobiosis and Inflammatory Responses in Women With Adverse Pregnancy Outcomes

et al. 2020

View full text Add to dashboard Cite

The microbiome modulates inflammation at the fetal maternal interface on both term and preterm labor. Inflammophilic oral bacteria, such as Porphyromonas gingivalis, as well as urogenital microorganisms (UGM) could translocate to the placenta and activate immune mechanisms in decidual tissue that is associated with adverse pregnancy outcomes (APO). This study establishes the associations between the presence of microbes in the placenta and placental cytokine patterns in women who presented APO, e.g., low birth weight (LBW), preterm premature rupture of membranes (PPROM), preterm birth (PTB) and other clinical signs related to Chorioamnionitis (CA). A total of 40 pregnant women were included in the study and divided into five groups according to placental infection (PI) and APO, as follows: (1) women without PI and without APO (n = 17), (2) women with P. gingivalis-related PI and APO (n = 5), (3) women with P. gingivalis-related PI and without APO (n = 4), (4) women with PI related to UGM and APO (n = 5) and (5) women without PI with APO (n = 9). Obstetric, clinical periodontal status evaluation, and subgingival plaque sampling were performed at the time of delivery. Placental levels of interleukin IL-1β, IL-6, IL-10, IL-15, IL-17A, IL-17F, IL-21, IL-12p70, tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 α (MCP-1α), granzyme B, and interferon-γ (IFN-γ) were determined using a multiplex flow cytometry assay. All patients showed a predominant Th-1 cytokine profile related to labor, characterized by IFN-γ overexpression. The analysis by groups suggests that Th-1 profile was trending to maintain cytotoxic cell activity by the expression of IL-15 and granzyme B, except for the group with P. gingivalis-related PI and APO, which exhibited a reduction of IL-10 and IL-17F cytokines (p < 0.05) and a Th-1 profile favoring macrophage activation by MCP-1 production (p < 0.05). This study confirms a pro-inflammatory pattern associated with labor, characterized by a Th-1 profile and the activity of cytotoxic cells, which is enhanced by PI with UGM. However, PI associated with P. gingivalis suggests a switch where the Th-1 profile favors an inflammatory response mediated by MCP-1 and macrophage activity as a mechanistic explanation of its possible relationship with adverse outcomes in pregnancy.

show abstract

“…Therefore, preventing the occurence of continuously regular uterine contraction is the premise to avoid adverse pregnancy events. The occurence of uterine contraction is interactive result of multiple factors [13] . However, there is little literature about risk factors of uterine contraction caused by ureteroscopy.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors of Uterine Contraction After Ureteroscopy in Pregnant Women With Renal Colic

Zhou

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: Ureteroscopy is widely applied in pregnant women with renal colic, but such patients are easy to experience uterine contraction after ureteroscopy, There are many factors which may result to uterine contraction, this study aims to explore the risk factors of uterine contraction triggered by ureteroscopy in pregnant women with renal colic. Methods: 101 pregnant women were retrospectively analyzed, all patients were hospitalized because of severe renal colic. All patients received ureteroscopy during which double J catheters were inserted into ureters for drainage. Patients received medical treatment individually according to their condition and the uterine contractions were detected by EHG within 12 hours after operation. Patients were classified as group A (uterine contraction, n=46) and group B (no uterine contraction, n=55) according to the presence or absence of continuously regular uterine contraction. Clinical characteristics were collected for further analysis, including history of deliveries, anesthesia methods, application of phloroglucinol or not, surgical time, Oxygen inhalation or not, pain relief or not after surgery, systemic inflammatory response syndrome(SIRS) occurred or not. A binary logistic regression analysis model was established to explore whether such clinical characteristics were relevant to uterine contraction after ureteroscopy. Results: The incidence of continuously regular uterine contraction occurred within 12 hours after ureteroscopy in pregnant women was 45.54%, and the presence of uterine contraction was related to the following factors(P<0.05): history of deliveries(primipara versus multipara)(OR=6.593, 95%CI 2.231-19.490), surgical time(each quarter additional)(OR=2.385, 95%CI 1.342-4.238), application of phloroglucinol(yes versus not)(OR=6.959, 95%CI 1.416-34.194), pain relief after surgery(yes versus not)(OR=6.707, 95%CI 1.978-22.738), SIRS occurred after surgery(yes versus not)(OR=0.099, 95%CI 0.014-0.713). Conclusion: Continuously regular uterine contraction is easy to occur within 12 hours after ureteroscopy in pregnant women. SIRS occurred after surgery is a risk factor for uterine contraction; on the contrary, no history of childbirth, shorter surgical time, application of phloroglucinol, pain relief after surgery are protective factors.

show abstract

Porphyromonas gingivalisand adverse pregnancy outcomes: a review on its intricate pathogenic mechanisms

Cited by 39 publications

References 168 publications

Porphyromonas gingivalis and Its Systemic Impact: Current Status

Porphyromonas gingivalis and Its Systemic Impact: Current Status

Porphyromonas gingivalis Placental Atopobiosis and Inflammatory Responses in Women With Adverse Pregnancy Outcomes

Risk Factors of Uterine Contraction After Ureteroscopy in Pregnant Women With Renal Colic

Contact Info

Product

Resources

About