<i>Pichia anomala</i> fungaemia in immunocompromised children

Bakır, Mustafa; Çerıkçıoğlu, Nilgũn; Tırtır, A.; Berrak, Su Gülsün; Özek, Eren; Canpolat, Cengiz

doi:10.1111/j.1439-0507.2004.00962.x

Cited by 39 publications

(12 citation statements)

References 27 publications

(78 reference statements)

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“…As a rarely described clinical nosocomial agent, Pichia spp. are usually associated with invasive infections and fungaemia in neonates and immunosuppressed individuals [ 99 , 100 , 101 ]. Standard fungal risk factors, such as prematurity, low birth weight, long duration of hospital stay, prior use of antibiotics, intravenous catheterization, intravenous drug abuse, etc., are associated with Pichia infection [ 101 ].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Characterization of Clinical Fungal Isolates from Pauls Stradinš Clinical University Hospital, Latvia: A 4-Year Surveillance Report

Jain

Jansone

Obidenova

et al. 2021

Life

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Nosocomial fungal infections are an emerging global public health threat that requires urgent attention and proper management. With the limited availability of treatment options, it has become necessary to understand the emerging epidemiological trends, mechanisms, and risk factors. However, very limited surveillance reports are available in the Latvian and broader European context. We therefore conducted a retrospective analysis of laboratory data (2017–2020) from Pauls Stradinš Clinical University Hospital (PSCUH), Riga, Latvia, which is one of the largest public multispecialty hospitals in Latvia. A total of 2278 fungal isolates were analyzed during the study period, with Candida spp. comprising 95% of the isolates, followed by Aspergillus spp. and Geotrichum spp. Amongst the Candida spp., C. albicans and C. glabrata made up about 75% of the isolates. The Department of Lung Diseases and Thoracic Surgery had the highest caseload followed by Intensive Care Department. Majority of the fungal isolates were collected from the bronchoalveolar lavage (37%), followed by urine (19%) and sputum (18%) samples. A total of 34 cases of candidemia were noted during the study period with C. albicans being the most common candidemia pathogen. Proper surveillance of emerging epidemiological trends serve as the most reliable and powerful cornerstone towards tackling this emerging threat.

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Section: Discussionmentioning

confidence: 99%

Epidemiological Characterization of Clinical Fungal Isolates from Pauls Stradinš Clinical University Hospital, Latvia: A 4-Year Surveillance Report

Jain

Jansone

Obidenova

et al. 2021

Life

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“…It was reported that in most of the C. pelliculosa cases, removing the catheter and amphotericin-B treatment created successful results in infections (6,23). Kalkancı et al (6) reported that C. pelliculosa fungemia was successfully treated by amphotericin-B, fluconazole and removal of the catheter.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the suspension prepared Minimal inhibition concentration (MIC) sensitivity values for fluconazole (≤8 µg/mL sensitive, 16-32 µg/mL dosesensitive, ≥64 µg/mL resistant) and for voriconazole (≤1 µg/ mL sensitive, 2 µg/mL dose-sensitive, ≥4 µg/mL resistant) were implemented according to CLSI recommendations (22). MIC value for caspofungin (≤2 µg/mL sensitive) was evaluated based on the reference of a study (23). For amphotericin B (≤1 µg/mL sensitive, ≥2 µg/mL resistant) was accepted (24).…”

Section: Antifungal Sensitivity Testmentioning

confidence: 99%

Candida Pelliculosa Fungemia Cases in Pediatric Intensive Care Unit

Otağ¹,

Yarpuzlu²,

Gülbudak³

et al. 2015

Çocuk Enf Derg

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Candida pelliculosa (teleomorph: Wickerhamomyces anomalus) is an opportunistic pathogen that rarely causes fungemia. Here we present two cases with C. pelliculosa fungemia in the pediatric intensive care unit. The fungemia developed as a result of horizontal transmission from a patient who was transferred from another hospital with the same condition. Strains isolated from blood cultures of the two patients were identified as Candida pelliculosa with API ID 32C (bioMerieux France) commercial kit. All strains were resistant to the same antibiotic and random amplified polymorphic DNA analysis type. E-test antifungal MIC levels were found in the order of 0.125 ug/mL, 24 ug/mL, 0.50 ug/mL, and 0.64 ug/mL for caspofungin, fluconazole, voriconazole, and amphotericin-B, respectively. Environmental samples for C. pelliculosa were negative. After measures to control the infection were implemented in the unit, the outbreak ended. In the case of hindering precautions, it should be taken into account that hospital-acquired infections can develop even from rarely encountered non-albicans Candida strains.

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“…Nosocomial infections caused by W. anomalus in adults and pediatric patients have been reported around the world with a mortality rate up to 38% and 42%, respectively [ 8 , 11 , 12 ]. The first published outbreak in PICU described five neonates with fungemia, two with fungemia and ventriculitis, and one with ventriculitis.…”

Section: Introductionmentioning

confidence: 99%

Fatal Case of Fungemia by Wickerhamomyces anomalus in a Pediatric Patient Diagnosed in a Teaching Hospital from Brazil

Dutra

Silva

Oliveira

et al. 2020

JoF

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In recent decades, emerging fungal infections have changed the clinical mycology scenario as a consequence of the advances in medical diagnostics and therapeutic procedures, long hospitalization times, and the growing number of individuals with debilitating chronic diseases and impaired immune systems. This report presents a 19 months old Brazilian female patient who developed a severe fungal sepsis by an uncommon yeast. She was admitted at the intensive care unit with severe pneumonia, bronchopulmonary dysplasia, and weight-for-age z score of less than −2. She remained more than 30 days in the intensive care unit where she had a femoral venous catheter placement, enteral nutrition, broad-spectrum antibiotic therapy, and prophylaxis with fluconazole. Moreover, pericardiocentesis was performed due to cardiac tamponade. She had a previous history of prematurity, cardiac surgery due to patent ductus arteriosus, and a long period of hospital stay. Despite the antifungal prophylaxis, two yeast isolates were recovered from blood and then identified by classical mycological methods and internal transcribed spacer (ITS) sequencing as Wickerhamomyces anomalus. Both isolates exhibited susceptibility to amphotericin B, ketoconazole, itraconazole, voriconazole, and fluconazole. Her clinical state worsened, presenting anasarca, epistaxis, and hemorrhagic suffusions in the mouth, sclera, oliguria, and bradycardia. Two days after the first positive culture, she presented a gradual reduction of the white blood cells count, with severe leukopenia and neutropenia. She died five days after.

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Pichia anomala fungaemia in immunocompromised children

Cited by 39 publications

References 27 publications

Epidemiological Characterization of Clinical Fungal Isolates from Pauls Stradinš Clinical University Hospital, Latvia: A 4-Year Surveillance Report

Epidemiological Characterization of Clinical Fungal Isolates from Pauls Stradinš Clinical University Hospital, Latvia: A 4-Year Surveillance Report

Candida Pelliculosa Fungemia Cases in Pediatric Intensive Care Unit

Fatal Case of Fungemia by Wickerhamomyces anomalus in a Pediatric Patient Diagnosed in a Teaching Hospital from Brazil

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