<i>Pasteurella multocida</i>Urinary Tract Infection with Molecular Evidence of Zoonotic Transmission

Liu, Wendy; Chemaly, Roy F.; Tuohy, Marion J.; LaSalvia, Margaret M.; Procop, Gary W.

doi:10.1086/367649

Cited by 25 publications

(26 citation statements)

References 16 publications

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“…multocida (hereafter referred to as P. multocida) is an economically important opportunistic pathogen of livestock (hemorrhagic septicemia, shipping fever, and atrophic rhinitis), poultry (fowl cholera), wildlife (avian cholera), and laboratory rabbits (snuffles) (1). As a commensal of cats and dogs, P. multocida also is a significant cause of zoonotic abscesses arising mainly from bites or scratches, but it has been increasingly associated with pulmonary disease, sepsis, and meningitis in patients with underlying medical conditions that may compromise their immune status (4,10,13,15,16,20,21,29,30,35,38,48). Although the so-called dermonecrotic toxin synthesized by some P. multocida strains produces atrophic rhinitis, the toxin is not essential for respiratory or systemic disease.…”

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Sialic Acid Metabolism and Systemic Pasteurellosis

et al. 2005

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Pasteurella multocida subsp. multocida is a commensal and opportunistic pathogen of food animals, wildlife, and pets and a zoonotic cause of human infection arising from contacts with these animals. Here, an investigation of multiple serotype A strains demonstrated the occurrence of membrane sialyltransferase. Although P. multocida lacks the genes for the two earliest steps in de novo sialic acid synthesis, adding sialic acid to the growth medium resulted in uptake, activation, and subsequent transfer of sialic acid to a membrane acceptor resembling lipooligosaccharide. Two candidate-activating enzymes with homology to Escherichia coli cytidine 5-monophospho-N-acetylneuraminate synthetase were overproduced as histidine-tagged polypeptides. The synthetase encoded by pm0187 was at least 37 times more active than the pm1710 gene product, suggesting pm0187 encodes the primary sialic acid cytidylyltransferase in P. multocida. A sialate aldolase (pm1715) mutant unable to initiate dissimilation of internalized sialic acid was not attenuated in the CD-1 mouse model of systemic pasteurellosis, indicating that the nutritional function of sialate catabolism is not required for systemic disease. In contrast, the attenuation of a sialate uptake-deficient mutant supports the essential role in pathogenesis of a sialylation mechanism that is dependent on an environmental (host) supply of sialic acid. The combined results provide the first direct evidence of sialylation by a precursor scavenging mechanism in pasteurellae and of a potential tripartite ATP-independent periplasmic sialate transporter in any species.

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Sialic Acid Metabolism and Systemic Pasteurellosis

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“…Human infections with P. multocida are in most cases of animal origin and are most often related to the bites of carnivores. However, other types of infections are also occasionally reported (25,28,34).Significant variations in the phenotypic properties of P. multocida have been reported (27), leading to confusion in the definition and identification of this organism. Mutters et al (37) reclassified the genus Pasteurella on the basis of DNA-DNA hybridization studies.…”

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Characterization of Sucrose-Negative Pasteurella multocida Variants, Including Isolates from Large-Cat Bite Wounds

et al. 2005

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To validate the identification of Pasteurella multocida-like bacteria negative for acid formation from sucrose, including isolates from bite wounds caused by large cats, 17 strains were phenotypically and genotypically characterized. Phylogenetic analysis of partially sequenced rpoB and infB genes showed the monophyly of the strains characterized and the reference strains of P. multocida. The sucrose-negative strains formed two groups, one related to reference strains of P. multocida and the other related to a separate species-like group (taxon 45 of Bisgaard). DNA-DNA hybridization further documented the species-like nature of this group. Ribotyping showed the heterogeneity of all strains except four strains that shared the same ribotype and that were isolated from bovine lungs. Phylogenetic analysis by 16S rRNA sequence comparison showed the monophyly of the strains characterized and the reference strains of P. multocida. Two strains isolated from leopard bite wounds were related to the type strain of P. dagmatis; however, they represented a new taxon (taxon 46 of Bisgaard), in accordance with their distinct phenotypic and genotypic identifications. The present study documents that sucrose-negative strains of P. multocida-like bacteria belong to two genotypically distinct groups. The study further confirms the phenotypic heterogeneity of P. multocida strains and documents two new species-like taxa of Pasteurella related to P. multocida. Until diagnostic tools have been further elaborated, special care should be taken in the identification of Pasteurella-like bacteria isolated from bite wounds caused by large cats. The evidence of phenotypic and genotypic divergence calls for the further development of PCR tests and DNA sequencing to document doubtful isolates.Pasteurella multocida has been isolated from a multitude of hosts (26), and different lineages of P. multocida may be responsible for various diseases in both birds and mammals (9, 15). Human infections with P. multocida are in most cases of animal origin and are most often related to the bites of carnivores. However, other types of infections are also occasionally reported (25,28,34).Significant variations in the phenotypic properties of P. multocida have been reported (27), leading to confusion in the definition and identification of this organism. Mutters et al. (37) reclassified the genus Pasteurella on the basis of DNA-DNA hybridization studies. Three clusters of P. multocida showing 84 to 100, 91 to 100, and 89 to 100% DNA reassociation between strains subsequently described as P. multocida subsp. multocida, P. multocida subsp. gallicida, and P. multocida subsp. septica, respectively, were identified. Representatives of the existing capsular types were found to be closely related on the basis of DNA-DNA hybridization (44), despite the diversity of disease manifestations and hosts. This is contradictory to the diversity shown by outer membrane protein profiling (17,18,19), multilocus enzyme electrophoresis (5), and ribotyping (43). The study of Pet...

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“…Rarely, P. multocida has been reported to be associated with other sites of infections, including pneumonia, upper respiratory tract infections, endocarditis, meningitis and UTIs [3]. A literature review of UTIs caused by P. multocitda revealed nine published cases with patient-specific information, summarized in Table 1 [4], [5], [6], [7], [8], [9], [10], [11]. There are also several earlier papers which mentioned the presence of urinary tract infection with P. multocida but did not provide details about the patient case or outcomes, and as such these are not included in our review [3], [12].…”

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confidence: 99%

Urinary tract infection with Pasteurella multocida in a patient with cat exposure and abnormal urinary tract physiology: Case report and literature review

Costanzo

Wojciechowski

Bajwa

2017

IDCases

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Pasteurella multocida is a gram-negative organism that commonly colonizes the mouth of cats and dogs, and is known to cause infection in humans associated with animal bites or scratches. Sites of infection other than skin and soft tissue are rare, but have been reported in patients with specific risk factors including anatomical abnormalities or immunosuppression. Herein, we report a case of a symptomatic urinary tract infection caused by P. multocida in a 59 year old female who presented to the hospital with complaints of systemic symptoms including malaise, rigors, and chills, as well as thick, malodorous urine. The patient self-catheterized multiple times daily due to urostomy with Kock pouch. Treatment with piperacillin/tazobactam followed by amoxicillin resulted in resolution of the infection.

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Pasteurella multocidaUrinary Tract Infection with Molecular Evidence of Zoonotic Transmission

Cited by 25 publications

References 16 publications

Sialic Acid Metabolism and Systemic Pasteurellosis

Sialic Acid Metabolism and Systemic Pasteurellosis

Characterization of Sucrose-Negative Pasteurella multocida Variants, Including Isolates from Large-Cat Bite Wounds

Urinary tract infection with Pasteurella multocida in a patient with cat exposure and abnormal urinary tract physiology: Case report and literature review

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