<i>Notes from the Field</i>: Fatalities Associated with Human Adenovirus Type 7 at a Substance Abuse Rehabilitation Facility — New Jersey, 2017

Rozwadowski, Faye; Caulcrick-Grimes, Mardea; McHugh, Lisa; Haldeman, AnnMarie; Fulton, Tara; Killerby, Marie E.; Schneider, Eileen; Lu, Xiaoyan; Sakthivel, Senthilkumar K.; Bhatnagar, Julu; Rabeneck, D. Brett; Zaki, Sherif R.; Watson, John T.

doi:10.15585/mmwr.mm6712a6

Cited by 18 publications

(13 citation statements)

References 4 publications

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“…The NJDOH was notified on February 3, 2017 of an outbreak involving 79 ARI cases at an alcohol and substance use rehabilitation facility during January 1–March 31, 2017, including 4 hospitalized cases [20]. Among the 79 ARI cases (59 inpatients and 20 staff), 25 cases had specimens tested for influenza, and 3 (12%) were positive.…”

Section: Resultsmentioning

confidence: 99%

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Respiratory Illness Associated With Emergent Human Adenovirus Genome Type 7d, New Jersey, 2016–2017

Killerby

Rozwadowski

et al. 2019

Open Forum Infectious Diseases

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BackgroundHuman adenoviruses (HAdVs) are known causes of respiratory illness outbreaks in congregate settings, but cases and clusters are less well described from community settings in the United States. During December 2016–February 2017, the New Jersey Department of Health received reports of HAdV infections from 3 sources in 3 adjacent counties. We investigated to characterize the epidemiologic, laboratory, and clinical features of this HAdV outbreak.MethodsA case was defined as a New Jersey resident with acute respiratory illness during December 1, 2016–March 31, 2017 with laboratory identification of HAdV genome type 7d (HAdV-7d). Human adenovirus was detected by real-time and conventional polymerase chain reaction and molecular typed by partial hexon capsid protein gene sequencing. The HAdV genome type was identified by whole genome sequencing analysis. Available medical, public health, and surveillance records were reviewed.ResultsWe identified 12 cases, including 3 treatment facility patients, 7 college students, and 2 cases at a tertiary-care hospital. Four cases died; all had underlying comorbidities. Nine HAdV-7d whole genome sequences obtained from all 3 sites were nearly identical.ConclusionsTransmission of HAdV-7d occurred in community and congregate settings across 3 counties and resulted in severe morbidity and mortality in some cases with underlying comorbidities. Clinicians and local and state health departments should consider HAdV in patients with severe respiratory infection.

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Section: Resultsmentioning

confidence: 99%

“…During December 2016–March 2017, hospitalized ARI cases were identified during an ARI outbreak in a substance use rehabilitation facility [20]. Influenza testing was initially performed at the facility.…”

Section: Methodsmentioning

confidence: 99%

Respiratory Illness Associated With Emergent Human Adenovirus Genome Type 7d, New Jersey, 2016–2017

Killerby

Rozwadowski

et al. 2019

Open Forum Infectious Diseases

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“…A suspected case is defined as the person who has two or more of the following acute respiratory infection symptoms without laboratory confirmation: fever, sore throat, cough, rhinorrhea, and headache [221]. A confirmed case is defined as the person who tested positive for adenovirus by the respiratory virus polymerase chain reaction (PCR), among the suspected cases.…”

Section: Methodsmentioning

confidence: 99%

Epidemiological Investigation of the Outbreak of Acute Respiratory Infection caused by Adenovirus Type B55 in a Physical Education School in 2017

2019

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Background On May 19, 2017, the cluster of 6 acute respiratory infections due to adenovirus in the swimming department of a physical education school (School J) was reported to Korea Centers for Disease Control and Prevention. An epidemiological investigation was conducted to identify the transmission route of the infection and to control the outbreak. Materials and Methods A retrospective cohort study (Study 1) was conducted on students and teachers of the athletic departments using the swimming pool, and a prospective surveillance (Study 2) was conducted on all students and teachers of the School J. A case was defined as any student and school personnel who developed more than two of the following symptoms from April 10 to July 2, 2017: fever, sore throat, cough, rhinorrhea, or headache. Relative risks (RRs) were calculated to compare the attack rates according to potential risk factors. Multivariable logistic regression was performed to identify the risk factors for infection in the outbreak. Results 47 cases were identified: 33 (55.9%) cases occurred among 59 students and teachers in Study 1 and 14 (3.9%) among 362 students and school personnel in Study 2. There were 18 laboratory confirmed adenovirus infection cases. The common symptoms were headache (71.7%), fever (69.6%), rhinorrhea (63.0%), sputum (56.5%), and sore throat (54.3%). 23.9% of the cases were accompanied with diarrhea and 19.6% with eye congestion. None of the cases developed pneumonia. 32.6% of the cases were hospitalized. In Study 1, attack rate in the swimming department was higher than that in others (RR: 1.90; 95% confidence interval [CI]: 1.01-3.60). In Study 2, being a member of the shooting department (RR: 20.70; 95% CI: 4.90-87.47) and being a first year high school student (RR: 10.95; 95% CI: 2.90-41.33) were identified as risk factors for the infections. Genetic analyses of the adenoviruses showed 100% identical sequence in homology and confirmed the human adenovirus B55 (HAdV-B55). No adenovirus was detected at examining the water and environment of the swimming pool and dormitory. Conclusion The outbreak is inferred to be occurred via propagated transmission among the students in the same athletic department, while the students with symptoms of respiratory infection continued performing school activities without any restrictions. Infection control measures such as early detection of symptoms of respiratory infection and restriction of group activity are necessary to prevent respiratory infection outbreak in the communal living setting.

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“…With annual estimates, unfortunately, Influenza and RSV are still the deadliest among the respiratory viruses. The other viruses, although data are not shown in the table, can also lead to death, even in a small proportion or in a local scenario, as it is the case for some reports regarding human adenovirus [102] , human metapneumovirus [103] and rhinovirus [104] .…”

Section: Virusmentioning

confidence: 97%

Biosensors for the detection of respiratory viruses: A review

Cordeiro²,

et al. 2020

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Highlights A review containing the newest contributions of biosensors for respiratory viruses’ detection is presented. Influenza virus, coronavirus and respiratory syncytial virus were extensively analyzed. Tables containing biosensors information regarding the detection of the viruses are presented. Discussion based on the new trends and authors accomplishments are applied. SARS-CoV-2 biosensors already published were included and analyzed.

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Notes from the Field: Fatalities Associated with Human Adenovirus Type 7 at a Substance Abuse Rehabilitation Facility — New Jersey, 2017

Cited by 18 publications

References 4 publications

Respiratory Illness Associated With Emergent Human Adenovirus Genome Type 7d, New Jersey, 2016–2017

Respiratory Illness Associated With Emergent Human Adenovirus Genome Type 7d, New Jersey, 2016–2017

Epidemiological Investigation of the Outbreak of Acute Respiratory Infection caused by Adenovirus Type B55 in a Physical Education School in 2017

Biosensors for the detection of respiratory viruses: A review

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