N‐Acetylcysteine an Allium Plant Compound Improves High‐Sucrose Diet‐Induced Obesity and Related Effects

Abstract

This study was designed to determine whether N-acetylcysteine (NAC, C5H9–NO3S), a compound from Allium species may be used as a complementary therapeutic agent, to inhibit high-sucrose induced-obesity and its effects on glucose tolerance, in vivo low-density lipoprotein (LDL)-oxidation and serum oxidative stress in rats. Initially, 24 male Wistar rats were divided into two groups: controls receiving standard chow (C, n = 6) and those receiving high-sucrose diet (HS, n = 18). After 22 days, (HS) group was divided into three groups (n = 6/group); (HS-HS) continued to eat high-sucrose diet and water; (HS-N) continued to eat high-sucrose diet and received 2 mg l−1-NAC in its drinking water; (HS-CN) changing high-sucrose to standard chow and receiving 2 mg l­1-NAC in its drinking water. After 22 days of the HS-group division (44 days of experimental period) body weight, body mass index and surface area were enhanced in HS-HS rats (P < .001). HS-HS rats had glucose intolerance, increased serum triacylglycerol (TG), very low-density lipoprotein (VLDL), oxidized-LDL (ox-LDL) and lipid-hydroperoxide (LH) than the others (P < .01). NAC in HS-N and HS-CN rats reduced the obesity markers, feed efficiency, LH and ox-LDL, as well normalized glucose response, TG and VLDL (P < .01) in these groups compared with HS-HS. Total antioxidant substances, GSH/GSSG ratio and glutathione-reductase, were higher in HS-N than in HS-HS (P < .01). In conclusion, NAC improved high-sucrose diet-induced obesity and its effects on glucose tolerance, lipid profile, in vivo LDL-oxidation and serum oxidative stress, enhancing antioxidant defences. The application of this agent may be feasible and beneficial for high-sucrose diet-induced obesity, which certainly would bring new insights on obesity-related adverse effects control.

Changes in glucose metabolism and reversion of genes expression in the liver of insulin-resistant rats exposed to malathion. The protective effects of N-acetylcysteine

“…Increasingly experimental and clinical data suggest that antioxidants have a beneficial role in the pathogenesis of insulin resistance (Souza et al, 2008;Masha et al, 2009). N-acetylcysteine (NAC), a cysteine donor, is of interest for many recent researchers because of its antioxidant, anti-inflammatory and hepatopreventive effects.…”

“…Recently, the antioxidant N-acetylcysteine (NAC) has been shown to exert a protective effect against insulin resistance and diabetes in rats (Haber et al, 2003;Song et al, 2005;Diniz et al, 2006;Souza et al, 2008). In these studies, NAC supplementation prevented hyperglycemia and glucose intolerance associated with the preservation of glucose-induced insulin secretion and improved insulin sensitivity.…”

Efeitos da annona muricata (graviola) e de seu componente β-sitosterol, sobre a adiposidade abdominal, resposta glicêmica, metabolismo energético à obesidade experiemental

“…• HB -recebendo dieta rica em sacarose e colesterol e solução aquosa desitosterol ad libitum, como no grupo PB O período experimental foi de 49 dias Souza, et al, 2008). A ração ofertada para os animais dos grupos HC, HA e HB foi preparada a partir do farelo da ração padrão, ou controle (Purina Labina, São Paulo, Brasil), obtida pela trituração desta ração até formação de farelo homogêneo.…”

“…Animais do grupo (HA, n=8) e (HB, n=8) receberam ração rica em colesterol e sacarose e para beber, receberam chá de Annona muricata e solução de -sitosterol, respectivamente. O período experimental foi de 49 dias Souza, et al, 2008).…”

Análise da expressão e mecanismos de ação das proteínas Akt, Hsp90, mTOR e ciclina D1 em cultura de células de carcinoma epidermoide humano e células displásicas após irradiação com laser em baixa intensidade

“…A N-acetilcisteína, por exemplo, é um composto organossulfurado encontrado em plantas do gênero allium, aspargos e pimenta vermelha (34,35) . O tratamento com base neste composto pode causar a inibição de crescimento de células de câncer oral que superexpressam EGFR (epidermal growth fator receptor).…”