Changes in glucose metabolism and reversion of genes expression in the liver of insulin-resistant rats exposed to malathion. The protective effects of N-acetylcysteine

Lasram, Mohamed Montassar; N, El-Golli; Lamine, Aicha Jrad; Douib, Ines Bini; Bouzid, K.; Annabi, Alya; Fazâa, Saloua El; Abdelmoula, J.; Gharbi, N.

doi:10.1016/j.ygcen.2014.10.002

Cited by 23 publications

(11 citation statements)

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“…stoechas. 21 Malathion-induced oxidative stress as well as liver and kidney dysfunctions have been shown to be attenuated by N-acetylcysteine, 44 vitamin C, and vitamin E. 45 However, to the best our knowledge, our report is the first one to deal with the LSEO protective effect on malathion-induced oxidative stress in the liver and kidney of young mice. The chemical composition of LSEO using the GC-MS technique has been done in our previous report, which allowed the identification of 22 compounds.…”

Section: Figmentioning

confidence: 80%

Hepatoprotective and Renoprotective Effects of Lavender (Lavandula stoechasL.) Essential Oils Against Malathion-Induced Oxidative Stress in Young Male Mice

Selmi

Jallouli²,

Gharbi³

et al. 2015

Journal of Medicinal Food

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We aimed in the present study to investigate the hepato-and nephroprotective effects of Lavandula stoechas essential oils (LSEO) against malathion-induced oxidative stress in young male mice as well as the possible mechanism implicated in such protection. Animals were divided into eight groups of 12 each: Control, malathion (200 mg/kg b.w.); Various doses of LSEO (10, 30, and 50 mg/kg b.w.), malathion + various doses of LSEO. Malathion and LSEO were daily per orally (p.o.) administered by intragastric gavage during 30 days. We initially found that malathion treatment induced body weight gain decrease as well as a clear nephro-and hepatotoxicity as assessed by significant relative liver and kidney weight increase and related hemodynamic parameters deregulation. Malathion exposure of mice also induced a considerable perturbation of metabolic parameters. On the other hand, we showed that malathion administration was accompanied by an oxidative stress status assessed by an increase of malondialdehyde (MDA) and hydrogen peroxide (H2O2) levels as well as a depletion of sulfhydril group content (-SH) and antioxidant enzyme activities such as catalase (CAT) and glutathione peroxidase (GPx), total superoxide dismutase (SOD), Cu/Zn-SOD, Mn-SOD, and Fe-SOD in the kidney and liver. More importantly, LSEO treatment abolished all malathion-induced body gain loss, liver and kidney relative weight increase, hemodynamic and metabolic disorders, as well as hepatic and renal oxidative stress. In conclusion, our data suggest that LSEO exerted potential hepato-and nephroprotective effects against malathion-induced oxidative stress in mice. The beneficial effect of LSEO might be related, in part, to its antioxidant properties.

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Section: Figmentioning

confidence: 80%

Hepatoprotective and Renoprotective Effects of Lavender (Lavandula stoechasL.) Essential Oils Against Malathion-Induced Oxidative Stress in Young Male Mice

Selmi

Jallouli²,

Gharbi³

et al. 2015

Journal of Medicinal Food

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“…Being a thiol (R-SH), it can be oxidized by various radicals and also serve as a nucleophile [111] . NAC is an artificial antioxidant that has shown positive results in both IBD animal models [112] and clinical trials [113] , in addition to being used with success in the treatment of several disorders, such as intoxication [111] , cardiac ischemia-reperfusion [114] , chronic obstructive pulmonary disease (COPD) [115] , bronchitis [116] , HIV/AIDS (Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome) [117] , psychiatric disorders [118] and diabetes [119] .…”

Section: Resultsmentioning

confidence: 99%

Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?

et al. 2015

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Oxidative stress (OS) is considered as one of the etiologic factors involved in several signals and symptoms of inflammatory bowel diseases (IBD) that include diarrhea, toxic megacolon and abdominal pain. This systematic review discusses approaches, challenges and perspectives into the use of nontraditional antioxidant therapy on IBD, including natural and synthetic compounds in both human and animal models. One hundred and thirty four papers were identified, of which only four were evaluated in humans. Some of the challenges identified in this review can shed light on this fact: lack of standardization of OS biomarkers, absence of safety data and clinical trials for the chemicals and biological molecules, as well as the fact that most of the compounds were not repeatedly tested in several situations, including acute and chronic colitis. This review hopes to stimulate researchers to become more involved in this fruitful area, to warrant investigation of novel, alternative and efficacious antioxidant-based therapies.

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“…2010a ) acting on liver adenylate cyclase, oxidative status, and proinflammatory markers ( Adigun et al. 2010a ; Lasram et al. 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor

Lukowicz

Ellero‐Simatos

Régnier

et al. 2018

Environ Health Perspect

114

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Background:Epidemiological evidence suggests a link between pesticide exposure and the development of metabolic diseases. However, most experimental studies have evaluated the metabolic effects of pesticides using individual molecules, often at nonrelevant doses or in combination with other risk factors such as high-fat diets.Objectives:We aimed to evaluate, in mice, the metabolic consequences of chronic dietary exposure to a pesticide mixture at nontoxic doses, relevant to consumers’ risk assessment.Methods:A mixture of six pesticides commonly used in France, i.e., boscalid, captan, chlorpyrifos, thiofanate, thiacloprid, and ziram, was incorporated in a standard chow at doses exposing mice to the tolerable daily intake (TDI) of each pesticide. Wild-type (WT) and constitutive androstane receptor–deficient (CAR−/−) male and female mice were exposed for 52 wk. We assessed metabolic parameters [body weight (BW), food and water consumption, glucose tolerance, urinary metabolome] throughout the experiment. At the end of the experiment, we evaluated liver metabolism (histology, transcriptomics, metabolomics, lipidomics) and pesticide detoxification using liquid chromatography–mass spectrometry (LC-MS).Results:Compared to those fed control chow, WT male mice fed pesticide chow had greater BW gain and more adiposity. Moreover, these WT males fed pesticide chow exhibited characteristics of hepatic steatosis and glucose intolerance, which were not observed in those fed control chow. WT exposed female mice exhibited fasting hyperglycemia, higher reduced glutathione (GSH):oxidized glutathione (GSSG) liver ratio and perturbations of gut microbiota–related urinary metabolites compared to WT mice fed control chow. When we performed these experiments on CAR−/− mice, pesticide-exposed CAR−/− males did not exhibit BW gain or changes in glucose metabolism compared to the CAR−/− males fed control chow. Moreover, CAR−/− females fed pesticide chow exhibited pesticide toxicity with higher BWs and mortality rate compared to the CAR−/− females fed control chow.Conclusions:To our knowledge, we are the first to demonstrate a sexually dimorphic obesogenic and diabetogenic effect of chronic dietary exposure to a common mixture of pesticides at TDI levels, and to provide evidence for a partial role for CAR in an in vivo mouse model. This raises questions about the relevance of TDI for individual pesticides when present in a mixture. https://doi.org/10.1289/EHP2877

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Changes in glucose metabolism and reversion of genes expression in the liver of insulin-resistant rats exposed to malathion. The protective effects of N-acetylcysteine

Cited by 23 publications

References 98 publications

Hepatoprotective and Renoprotective Effects of Lavender (Lavandula stoechasL.) Essential Oils Against Malathion-Induced Oxidative Stress in Young Male Mice

Hepatoprotective and Renoprotective Effects of Lavender (Lavandula stoechasL.) Essential Oils Against Malathion-Induced Oxidative Stress in Young Male Mice

Antioxidant therapy for treatment of inflammatory bowel disease: Does it work?

Metabolic Effects of a Chronic Dietary Exposure to a Low-Dose Pesticide Cocktail in Mice: Sexual Dimorphism and Role of the Constitutive Androstane Receptor

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