N‐[4‐(3H‐1,3,4‐Oxadiazoline‐2‐thion‐5‐yl)phenyl]‐N′‐substituted Thioureas: Synthesis and Antimicrobiological Activities

Abstract

Diverse pharmacological properties are associated with 3H-1,3,4-oxadiazoline-2-thione derivatives, These include anticonvulsant14) and fungicidal" properties. On the other hand thiourea derivatives possess antiphyto-viral6), virucidal'), growth and herbicide"' activities. All these data prompted us to combine these moieties into a single molecule. The compounds synthesized were tested for their antimicrobial activities against seven microorganisms.

Synthesis and evaluation of antiviral, antitubercular and anticancer activities of some novel thioureas derived from 4-aminobenzohydrazide hydrazones

“…with substituted phenyl isothiocyanates in dry acetonitrile in yields between 42 and 68% (Scheme 1). The reaction for thiourea was reported to be performed in certain dry solvents or mixtures (18)(19)(20)(21). In the present study, dry acetonitrile was tried and found to be useful.…”

Synthesis and Anticonvulsant Activity of New N‐(Alkyl/Sub‐stituted aryl)‐N′‐[4‐(5‐cyclohexylamino)‐1,3,4‐thiadiazole‐2‐yl)phenyl]thioureas

“…1 H-NMR spectra were recorded in DMSO on a Bruker Avance-DPX-400 spectrometer (Bruker Bioscience, Billerica, MA, USA) in DMSO-d 6 and chemical shifts were given in d ppm with tetramethylsilane (TMS). The splitting patterns of 1 H-NMR were designed as follows: s: singlet, d: doublet, t: triplet, q: quartet, m: multiplet.…”

Synthesis and Biological Evaluation of Some Novel S-β-D-Glucosides of 4-Amino-5-alkyl-1,2,4-triazole-3-thiones Derivatives

“…1,2,4-Triazole and its derivatives are an important class of compounds which possess diverse biological activities including anti-microbial, 1,2 antibacterial, 3,4 antifungal, 5,6 anti-inflammatory, 7 insecticidal, 8 anticonvulsant, 9,10 antitumor activity, 11 anti HIV activity, 12,13 hypoglycemic 14 and anticonvulsant. 15,16 Triadimefon and fluconazole which exhibits excellent fungicidal activities possessing 1,2,4-triazole nucleus. 17,18 Compounds containing an azomethine group known as Schiff bases and are formed by the condensation of a primary amine with a carbonyl compound.…”