<i>Mycobacterium tuberculosis</i>Complex,<i>Mycobacterium leprae</i>, and Other Slow-Growing Mycobacteria

Pfyffer, Gaby E.; Vincent, Véronique

doi:10.1002/9780470688618.taw0046

Cited by 8 publications

(3 citation statements)

References 432 publications

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“…Whatever the cause, the occurrence of active TB in the HIV-positive patient has very serious consequences, worsening the prognosis of HIV infection. 4 The interaction between HIV and TB in persons coinfected with them is bidirectional and synergistic. The course of HIV infection is accelerated subsequent to development of TB and the inverse relationship between HIV viremia and CD4+T cell count gets shifted to the right.…”

Section: Introductionmentioning

confidence: 99%

Comparison of CD4 and CD8 counts and ratio in HIV negative pulmonary tuberculosis patients with normal healthy controls

Sabhapandit¹,

Hazarika²,

Phukan³

et al. 2017

Int J Res Med Sci

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Background: There is an equivocal contention that Tuberculosis may be a cause of non-HIV-associated CD4+ T cell lymphopenia. In HIV negative patients, CD4+ and CD8+ T cell count suppression has been associated with TB infection. Prediction of HIV coinfection in newly diagnosed pulmonary TB patients with negative HIV status by estimation of CD4, CD8 count and CD4:CD8 ratio.Methods: Newly diagnosed pulmonary TB patients comprising of 30 numbers with negative HIV status were subjected for estimation of CD4, CD8 counts and ratio for prediction of HIV coinfection. Equal number of healthy controls was also included in the study for comparison of the values.Results: Significantly lower CD4 and CD8 counts among pulmonary TB infected HIV negative patients as compared with healthy controls was found. The CD4:CD8 ratio was normal when compared with healthy controls.Conclusions: The present study highlights the importance of estimation of CD4+ and CD8+ T cell counts and ratio in newly diagnosed pulmonary TB patients with negative HIV status. Prediction ability in combination with early detection and appropriate management play major role in evading emergence of drug resistance among the HIV-TB coinfected patients.

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Section: Introductionmentioning

confidence: 99%

Comparison of CD4 and CD8 counts and ratio in HIV negative pulmonary tuberculosis patients with normal healthy controls

Sabhapandit¹,

Hazarika²,

Phukan³

et al. 2017

Int J Res Med Sci

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“…Microscopic examination of sputum and other specimens by Ziehl-Neelsen staining is the only rapid, relatively simple and inexpensive test for diagnosis of active pulmonary TB and EPTB. But, the reported sensitivity of Ziehl-Neelsen staining of unprocessed sputum smears from adults is only 40 to 70% because 5×10 3 to 5×10 4 organism/ml specimen is needed for the detection of bacilli [16]. Culture is also done for isolation and identification of M. tuberculosis but it is time consuming, bio-hazardous and needs bio-safety facilities.…”

Section: Diagnosis Of Tb: Diagnosis Of Tuberculosis (Tb)mentioning

confidence: 99%

Tuberculosis – burden and serodiagnosis

Mohiuddin¹

2020

IMC J Med Sci

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“…[ 1 ] Diagnosis of pulmonary tuberculosis currently relies upon the detection of the M. tuberculosis complex in sputum. [ 2 ] Diagnosis of pulmonary tuberculosis is difficult in patients who cannot produce sputum (pediatric, immunocompromised, and neurologically impaired patients). In the absence of adequate sputum production, respiratory tract specimens can be obtained by some invasive or inconvenient procedures, including nasopharyngeal aspirates, bronchoalveolar lavage, and gastric aspirate.…”

Section: Introductionmentioning

confidence: 99%

Detection of Mycobacterium tuberculosis on stool specimens by PCR among patients with pulmonary tuberculosis

Kesarwani

Singh

Kashyap

et al. 2022

J Family Med Prim Care

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Background: To detect Mycobacterium tuberculosis on stool specimens by polymerase chain reaction (PCR) among patients with pulmonary tuberculosis. Detection of M. tuberculosis complex in sputum forms the basis of diagnosis of pulmonary tuberculosis. However, some patients tend to swallow sputum and some are unable to produce sputum. Based on the survival of M. tuberculosis in the gastric fluid, swallowed organisms may be detectable in stool samples. Methods: The study was carried out on 30 cases each in four groups: sputum smear-positive and sputum smear-negative adults, pediatric patients suspected of pulmonary tuberculosis along with healthy controls. The samples were processed for direct microscopy for acid-fast bacilli (AFB) and M. tuberculosis culture. Stool PCR was done on all 120 samples. Results: AFB was demonstrated in 42 and cultured in 39 out of 240 samples. PCR-targeting IS6110 gene showed positive results in 24 (20%) out of 120 stool samples. PCR in stool showed the highest positivity in sputum smear-positive samples followed by gastric aspirates and sputum smear-negative samples. Conclusion: Stool PCR is a potentially useful diagnostic method for pulmonary tuberculosis.

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Mycobacterium tuberculosisComplex,Mycobacterium leprae, and Other Slow-Growing Mycobacteria

Cited by 8 publications

References 432 publications

Comparison of CD4 and CD8 counts and ratio in HIV negative pulmonary tuberculosis patients with normal healthy controls

Comparison of CD4 and CD8 counts and ratio in HIV negative pulmonary tuberculosis patients with normal healthy controls

Tuberculosis – burden and serodiagnosis

Detection of Mycobacterium tuberculosis on stool specimens by PCR among patients with pulmonary tuberculosis

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