<i>Mycobacterium bovis</i>in Swine: Spoligotyping of Isolates from Argentina

Barandiarán, Soledad; Vivot, Marcela Martínez; Moras, E.V.; Cataldi, Angel; Zumárraga, Martín José

doi:10.4061/2011/979647

Cited by 21 publications

(15 citation statements)

References 18 publications

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“…SB0520 has been described only in Argentina. 11 SB0145 has been described as the most extensively distributed genotype, found in Argentina, 9,10,12,13 Australia, 14 Brazil, 15 France, 5 Northern Ireland, 16,17 and other countries (as seen at http://www.mbovis.org).…”

Section: Resultsmentioning

confidence: 99%

Association between spoligotype-VNTR types and virulence ofMycobacterium bovisin cattle

Garbaccio¹,

Macias

Shimizu

et al. 2014

Virulence

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Section: Resultsmentioning

confidence: 99%

Association between spoligotype-VNTR types and virulence ofMycobacterium bovisin cattle

Garbaccio¹,

Macias

Shimizu

et al. 2014

Virulence

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“…Spoligotype SB0140 has infected cattle, deer, badgers and people in Source: http://spoltools.emi.unsw.edu.au/ Ireland (de la McLernon et al, 2010), and cattle in the United Kingdom (de la RuaDomenech et al, 2006;McLernon et al, 2010). It has also been reported as the most frequent spoligotype in pigs (Barandiaran et al, 2011), cattle and cats in Argentina (Zumárraga et al, 2009), and humans in the United States (Rodwell et al, 2008) and Mexico (Bobadilla-del Valle et al, 2015). Spoligotype SB0140 has been studied profoundly in the United Kingdom (Smith et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Genetic diversity of Mycobacterium bovis in Jalisco, Mexico: Tracing back sources of infection

GonzÃ¡lez-Ruiz¹,

Sosa-Gallegos²,

RodrÃguez-HernÃ¡ndez³

et al. 2018

J. Vet. Med. Anim. Health

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Bovine tuberculosis (bTB) is a disease of cattle that presents risk to public health, causing severe economic losses to the livestock industry and difficulty in eradication because of its complex epidemiology. The aim of this study was to identify relationships between Mycobacterium bovis strains from cattle in the State of Jalisco, and those of other States of México. Molecular fingerprints of 337 M. bovis isolates from Jalisco, and 1152 from other States of México were included in the study. Isolates were obtained from tubercles between 1997 and 2015. Evolutionary relationship was determined throughout spoligoforest (www.emi.unsw.edu.au/spoltools/). From 337 isolates from Jalisco, 59 spoligotypes were obtained, ten of them included 48% of all isolates in the state. Five spoligotypes were common to beef and dairy cattle. The molecular analysis showed eight clusters in a philogenetic three: one with three subclusters of nine isolates each, all from dairy cattle; four with two isolates, including dairy and beef cattle. All spoligotypes from Jalisco have been reported in other states, four of the most frequent ones: SB0673, SB0971, SB0669 and SB0140, were the same as in other states. The most frequent spoligotypes of M. bovis found in Jalisco were also the most frequent ones in other parts of Mexico. However, there is no evidence to conclude that Jalisco is the source of infection to other states since no information on movement and destination of cattle could be documented.

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“…Bovine TB is a recrudescent zoonosis whose eradication has eluded some of the least and most developed countries in the world. In most developing countries, bovine TB is endemic and there is little information available regarding the relationship between M. bovis infection in livestock, wildlife and the disease in humans [1,2]. The World Health Organization recently classified human TB caused by M. bovis as a “neglected zoonosis” [2].…”

Section: Introductionmentioning

confidence: 99%

“…Porcine TB caused by M. bovis has been reported in Argentina, South Africa and West Africa [1,9-11]. In South Africa, M. bovis accounted for 2.5% of isolated mycobacteria from pigs with pathological lesions [10].…”

Section: Introductionmentioning

confidence: 99%

“…In South Africa, M. bovis accounted for 2.5% of isolated mycobacteria from pigs with pathological lesions [10]. Pigs can become infected from cattle by the oral route [1], and outbreaks have been associated with infected yards or buildings contaminated with infected faecal material, feeding piglets with infected cattle milk and contact with wild life [9-12]. Unlike in the past where pigs were considered an epidemiological dead end in transmission of bovine TB, reports in Spain and Portugal show a multi-directional cross contamination between domestic pigs and wild boars [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Mycobacterium bovis infections in slaughter pigs in Mubende district, Uganda: a public health concern

et al. 2012

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BackgroundBovine tuberculosis (TB) caused by Mycobacterium bovis is primarily a disease of ruminants, particularly cattle (Bos primigenius) and buffalo (Syncerus caffer), and is endemic in most developing countries. To date, studies done in Uganda have documented the prevalence of M. bovis in cattle, humans and wild life, in addition to non-tuberculous mycobacteria in pigs. Pigs are increasingly becoming an important component of the livestock sector and share the human ecosystem in rural Uganda. It is therefore of public health interest that they are not a source of human infections. As a follow up to previously published findings on mycobacteria in pigs, this study was aimed at investigating the occurrence and molecular characteristics of M. bovis detected in slaughter pigs in Mubende district, Uganda. One hundred fifty mesenteric lymph nodes with lesions suggestive of mycobacterial infections were collected from approximately one thousand slaughtered pigs in Mubende district over a period of five months. The isolation and identification of M. bovis was done using conventional mycobacteriological methods. Mycobacteria belonging to the Mycobacterium tuberculosis complex (MTC) were identified to species level using deletion analysis. Molecular typing was done using Spoligotyping and MIRU-VNTR analysis. Molecular data were analysed and interpreted using MIRU-VNTR plus, SpolDB4.0 and the Mycobacterium bovis spoligo database.ResultsOf the examined animals, one boar and two sows from Madudu Sub County were infected with M. bovis which presented as lesions of a deep yellow colour and a grit-like texture in the mesenteric lymph nodes. This represents 2% (3/150) of the lymph nodes where lesions suggestive of mycobacterial infections were detected. Molecular analysis revealed that the isolates from the infected pigs showed identical MIRU-VNTR profile and spoligotype (SB1469).ConclusionsThis is the first study documenting the occurrence of M. bovis in slaughter pigs in Uganda, revealing that one in fifty slaughter pigs with suspected lesions in mesenteric lymph nodes were infected. Molecular analysis revealed that the isolates were identical, showing a spoligotype previously reported from humans and cattle in the north eastern part of the Uganda cattle corridor. This finding is of public health importance, therefore there is a need for close cooperation between medical and veterinary professionals in designing and implementing control and prevention measures that safeguard the public from this potential source of zoonotic TB in Uganda.

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Mycobacterium bovisin Swine: Spoligotyping of Isolates from Argentina

Cited by 21 publications

References 18 publications

Association between spoligotype-VNTR types and virulence ofMycobacterium bovisin cattle

Association between spoligotype-VNTR types and virulence ofMycobacterium bovisin cattle

Genetic diversity of Mycobacterium bovis in Jalisco, Mexico: Tracing back sources of infection

Mycobacterium bovis infections in slaughter pigs in Mubende district, Uganda: a public health concern

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