<i>Moringa oleifera</i> seed oil partially abrogates 2,3-dichlorovinyl dimethyl phosphate (Dichlorvos)-induced cardiac injury in rats: evidence for the role of oxidative stress

Saka, W.A.; Ayoade, Titilayo Eunice; Akhigbe, T. M.; Akhigbe, R.E.

doi:10.1515/jbcpp-2019-0313

Cited by 21 publications

(18 citation statements)

References 62 publications

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“…According to The Fourth Universal Definition of In Myocardial Infarction, the pathological analysis denotes MI as myocardial cell death due to prolonged ischemia ( Thygesen et al, 2018 ). MO increased cardiac antioxidant status, which led to the improvement of MI biomarkers, cardiac contractility, morphology of cardiac muscle, inflammatory cytokines, and apoptotic markers ( Panda et al, 2013 ; Panda, 2015 ; Khalil et al, 2020 ; Saka et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

The Potency of Moringa oleifera Lam. as Protective Agent in Cardiac Damage and Vascular Dysfunction

et al. 2022

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Cardiac damage and vascular dysfunction due to underlying diseases, such as hypertension and cardiac thrombosis, or side effects from certain drugs may lead to critical illness conditions and even death. The phytochemical compounds in natural products are being prospected to protect the heart and vascular system from further damage. Moringa genus is a subtropical tree native to Asia and Africa, which includes 13 species; Moringa oleifera Lam. (MO) is the most cultivated for its beneficial uses. MO is also known as the “miracle tree” because it has been used traditionally as a food source and medicine to treat various diseases such as anemia, diabetes, and infectious or cardiovascular diseases. The phytochemical compounds identified in MO with functional activities associated with cardiovascular diseases are N,α-L-rhamnopyranosyl vincosamide, isoquercetin, quercetin, quercetrin, and isothiocyanate. This study aims to investigate the potency of the phytochemical compounds in MO as a protective agent to cardiac damage and vascular dysfunction in the cardiovascular disease model. This is a scoping review by studying publications from the reputed database that assessed the functional activities of MO, which contribute to the improvement of cardiac and vascular dysfunctions. Studies show that the phytochemical compounds, for example, N,α-L-rhamnopyranosyl vincosamide and quercetin, have the molecular function of antioxidant, anti-inflammation, and anti-apoptosis. These lead to improving cardiac contractility and protecting cardiac structural integrity from damage. These compounds also act as natural vasorelaxants and endothelium protective agents. Most of the studies were conducted on in vivo studies; therefore, further studies should be applied in a clinical setting.

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Section: Discussionmentioning

confidence: 99%

The Potency of Moringa oleifera Lam. as Protective Agent in Cardiac Damage and Vascular Dysfunction

et al. 2022

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“…Exposure to DDVP: Group B and C animals were exposed to 98.54g/m 3 of DDVP via inhalation, as Saka et al (2020) reported. In addition, 1ml of the pesticide was soaked in cotton wool and placed in a desiccator.…”

Section: Drugs and Chemicalsmentioning

confidence: 99%

Hepatoprotective and Renoprotective effect of Moringa oleifera Seed Oil on Dichlorvos-induced Toxicity in Male Wistar rats

Adeoye¹,

Adeshina

Yusuf

et al. 2022

NJPS

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Objectives: The liver and the kidney are one of the vital organs of body. Drug induced toxicity is one of the most common problems encountered by these organ. The search for an effective medicine to treat this toxicity without any side effects has led to the use of traditional-based medicine. This study evaluated the effect of ethanolic extract of Moringa oleifera seed oil on hepatic and renal markers in dimethyl 2, 2-dichlorovinyl phosphate (DDVP, known as dichlorvos)-exposed wistar rats.Materials and Methods: Twenty one male wistar rats were randomly divided into three groups of seven animals each. Group A served as the negative control and were not exposed to dichlorvos. Group B served as the positive control and were exposed to dichlorvos for 2 minutes but received no extract. Group C were exposed to the dichlorvos and received 300mg/kg of extract (Moringa oleifera seed oil) for 7days before and 21days after exposureResults: Exposure to DDVP led to significant increase in hepatic & renal markers, inflammatory markers, decrease in plasma protein and alteration of plasma electrolyte. Moringa oleifera seed oil regulated and significantly enhanced plasma protein, reduced elevated level of hepatic & renal markers, inflammatory markers in the study sample. In addition, histopathology observation showed that Moringa seed oil was able to regenerate the hepatorenal damage on exposure to dichlorvos. Conclusion: Moringa oleifera seed oil exhibited hepato-protective, nephro-protective properties and could be explored in nutrition and health.Keywords: , Hepatic, Renal, Histopathology, Moringa oleifera, Dichlorvos

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“…Studies have shown that various parts of the plant (especially the leaves, seeds and roots) have medicinal value. Moringa oleifera has been demonstrated to possess analgesic, antipyretic, anti-diabetic, and hypotensive properties (Saka et al, 2020). It has also been reported to exert antioxidant (Charoensin, 2014;Saka et al, 2020), anti-inflammatory (Cheenpracha et al, 2010), and antimicrobial/antibacterial (Rahman et al, 2009) activities.…”

Section: Introductionmentioning

confidence: 99%

“…Moringa oleifera has been demonstrated to possess analgesic, antipyretic, anti-diabetic, and hypotensive properties (Saka et al, 2020). It has also been reported to exert antioxidant (Charoensin, 2014;Saka et al, 2020), anti-inflammatory (Cheenpracha et al, 2010), and antimicrobial/antibacterial (Rahman et al, 2009) activities. Although various parts of the plants exert these activities, the leaves have been reported to be commonly used due to its wide range of beneficial biological activities (Xu et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

“…The biological activities of Moringa oleifera have been attributed to its phytochemical constituents, viz. carotenoids, vitamins, minerals, amino acids, saponins, terpenoid, sterols, glycosides, alkaloids, flavonoids, tannins, anthraquinones, and phenolics (Siddhuraju and Becker, 2003;Anwar et al, 2007;Saka et al, 2020). Although, reports on the effect of Moringa oleifera on caspase 3-mediated apoptosis are scarce, it is likely that Moringa oleifera-mediated maintenance of redox balance and modulation of cytokines suppresses caspase 3 activity.…”

Section: Introductionmentioning

confidence: 99%

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Methanolic Moringa oleifera leaf extract protects against epithelial barrier damage and enteric bacterial translocation in intestinal I/R: Possible role of caspase 3

Afolabi

Akhigbe

et al. 2022

Front. Pharmacol.

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Background: Activation of caspase 3 has been implicated in the pathogenesis of I/R injury in various organs, but there is a paucity of data on its role in IIRI. Also, no reports were found on the beneficial role of methanolic Moringa oleifera leaf extract (MMOLE) in IIRI. This study investigated the involvement of caspase 3 in IIRI, and the impact of MMOLE in IIRI.Methods: Male Wistar rats were randomized into five groups; the sham-operated group that was sham-operated and received 0.5 ml of distilled water for 7 days prior to sham surgery, and the IIRI, febuxostat (FEB) +IIRI, low dose MMOLE (LDMO)+IIRI, and high dose MMOLE (HDMO)+IIRI groups that underwent I/R and also received 0.5 ml of distilled water, 10 mg/kg of febuxostat, 200 mg/kg of MMOLE, and 400 mg/kg of MMOLE respectively for 7 days prior to I/R. Markers of hepatic function, oxidative stress, and inflammation as well as enteric bacterial translocation and histoarchitecture integrity of intestinal and hepatic tissues were evaluated. The bioactive components of MMOLE were also determined by GC-MS.Results: As revealed by GC-MS, the active bioactive components of MMOLE were thiosemicarbazone, hydrazine, 1,3-dioxolane, octanoic acid, 1,3-benzenediamine, 9-octadecenoic acid, oleic acid, nonadecanoic acid, 3-undecanone, phosphonic acid, and cyclopentanecarboxylic acid. MMOLE alleviated IIRI-induced rise in intestinal and hepatic injury markers, malondialdehyde, TNF-α, IL-6, and myeloperoxidase activities. MMOLE improved IIRI-induced suppression of reduced glutathione, thiol and non-thiol proteins, and superoxide dismutase, catalase and glutathione peroxidase activities. These were associated with suppression of IIRI-induced caspase 3 activity and bacterial translocation. Histopathological evaluation revealed that MMOLE attenuated IIRI-induced alterations in intestinal and hepatic histoarchitecture integrity. MMOLE also militated against increased absolute and relative intestinal and hepatic weight, intestinal and hepatic injuries, epithelial mucosal barrier dysfunction, and enteric bacterial translocation associated with IIRI by downregulating oxidative stress-mediated activation of caspase 3.Conclusion: IIRI is associated with a rise in caspase 3 activity. Also, MMOLE confers protection against IIRI, possibly due to its constituent bioactive molecules, especially hydrazine, 9-octadecenoic acid, 1,3-dioxolane, oleic acid, and nonadecanoic acid.

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Moringa oleifera seed oil partially abrogates 2,3-dichlorovinyl dimethyl phosphate (Dichlorvos)-induced cardiac injury in rats: evidence for the role of oxidative stress

Cited by 21 publications

References 62 publications

The Potency of Moringa oleifera Lam. as Protective Agent in Cardiac Damage and Vascular Dysfunction

The Potency of Moringa oleifera Lam. as Protective Agent in Cardiac Damage and Vascular Dysfunction

Hepatoprotective and Renoprotective effect of Moringa oleifera Seed Oil on Dichlorvos-induced Toxicity in Male Wistar rats

Methanolic Moringa oleifera leaf extract protects against epithelial barrier damage and enteric bacterial translocation in intestinal I/R: Possible role of caspase 3

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