<i>Moringa oleifera</i>Prevents Selenite-Induced Cataractogenesis in Rat Pups

Sasikala, V.; Rooban, B.N.; Priya, S.; Sahasranamam, V.; Abraham, Annie

doi:10.1089/jop.2010.0049

Cited by 48 publications

(21 citation statements)

References 27 publications

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“…The phytochemicals in medicinal plants have attracted a great attention due to the fewer side effects and are cost effective. Many medicinal plants have shown to possess anticataractogenic potential by means of strong antioxidant activity associated with them (Lija et al, 2006;Biju et al, 2007;Rooban et al, 2009;Sasikala et al, 2010;Vibin et al, 2010). Cassia tora Linn.…”

Section: Discussionmentioning

confidence: 99%

Cassia tora leaves modulates selenite cataract by enhancing antioxidant status and preventing cytoskeletal protein loss in lenses of Sprague Dawley rat pups

Vasudevan

Abraham

2016

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 99%

Cassia tora leaves modulates selenite cataract by enhancing antioxidant status and preventing cytoskeletal protein loss in lenses of Sprague Dawley rat pups

Vasudevan

Abraham

2016

Journal of Ethnopharmacology

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“…This preoxidant and other free radicals generated through auto-oxidation of sugars lead to oxidative stress (Jyothi et al, 2003;Marsili et al, 2004;Gupta et al, 2009) to which the lens is highly susceptible (Sasikala et al, 2010). Previous studies established oxidative stress as a triggering factor in the development of cataract (Williams, 2006) with augmentation of the antioxidant defenses of the lens seen to prevent or delay cataractogenesis (Spector, 1995).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the effect of <i>Spathodea campanulata</i> flower bud exudate on cataractogenesis in rat lenses

Gbemisola¹,

Faluyi²,

Osoniyi³

2015

Afr. J. Trad. Compl. Alt. Med.

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Background: The flower bud exudates of Spathodea campanulata is commonly used as a local eye drop in Nigeria and is anecdotally claimed to improve vision. This study evaluated the anti-cataract activity of Spathodea campanulata (SPCM) flower bud exudates against cataractogenesis using rat lenses. This was done with a view to providing empirical scientific support for the use of the exudates from SPCM in the treatment and management of certain eye disorders. Materials and Methods: Fifty (50) rat lenses were used in this study, i.e. five groups of ten (10) lenses per group. Lenses were incubated in artificial aqueous humor (Normal control) with simultaneous incubation in 30 mM galactose (Untreated cataract). Co-incubation with captopril (Captopril treated cataract); 0.1 mg/ml of the exudate (Exudate treated cataract -Low dose) and 0.2 mg/ml of exudate (Exudate treated cataract-High dose) constituted the study groups. After 72 hr of incubation, lenses were observed for cataract and the preventive potential of the exudate against cataractogenesis was evaluated through the determination of the levels of anti-oxidant parameters such as total protein (TP), glutathione (GSH), malondialdehyde (MDA) and activities of superoxide dismutase (SOD) and catalase (CAT) were evaluated in the lens homogenates. Results: Photographic evaluation of the lenses showed the development of cataract in the untreated cataract group while opacification was retarded in higher dose exudate-treated and captopril treated lenses. Significant decrease in the levels of GSH and total protein, reduction in SOD and CAT activities as well as increase in MDA content were observed in cataractous lenses when compared with the normal control. SPCM displayed a doserelated anti-cataract activity. Captopril showed comparable anti-cataract potential to (0.2 mg/ml) SPCM. GSH, SOD and CAT activity in captopril treated cataract lenses increased to 75.55%, 64.08% and 72.45% of the normal control values respectively. In (0.2 mg/ml) exudate treated cataract lenses; GSH, SOD and CAT activity increased to 57.7%, 76.69% and 80.61% respectively. Conclusion:The study concluded that exudate of SPCM elicited its anti-cataract potential through its anti-oxidant activities.

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“…Ellagic acid inhibited the formation of cataracts induced by selenite in Wistar rats (Sakthivel et al, 2008) and prevented alterations in lens proteins (Sakthivel et al, 2011). The polyphenols in Moringa oleifera also prevented cataract formation in selenite-treated rat pups (Sasikala et al, 2010). Diabetic cataracts in streptozotocin-induced diabetic rats were prevented by soy isoflavones (Lu et al, 2008a; Lu et al, 2008b) although it was suspected that isoflavones were increasing insulin secretion/susceptibility rather than having antioxidant activity.…”

Section: Dietary Factors Associated With Altered Lens Cataract Risksmentioning

confidence: 99%

Small molecules, both dietary and endogenous, influence the onset of lens cataracts

Barnes

Quinlan

2017

Experimental Eye Research

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How the lens ages successfully is a lesson in biological adaption and the emergent properties of its complement of cells and proteins. This living tissue contains some of the oldest proteins in our bodies and yet they remain functional for decades, despite exposure to UV light, to reactive oxygen species and all the other hazards to protein function. This remarkable feat is achieved by a shrewd investment in very stable proteins as lens crystallins, by providing a reservoir of ATP-independent protein chaperones unequalled by any other tissue and by an oxidation-resistant environment. In addition, glutathione, a free radical scavenger, is present in mM concentrations and the plasma membranes contain oxidation-resistant sphingolipids, so what compromises lens function as it ages? In this review, we examine the role of small molecules in the prevention or causation of cataracts, including those associated with diet, metabolic pathways and drug therapy (steroids).

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Moringa oleiferaPrevents Selenite-Induced Cataractogenesis in Rat Pups

Abstract: FMO was effective in preventing cataractogenesis in selenite model by enhancing the activities of antioxidant enzyme, reducing the intensity of lipid peroxidation, and inhibiting free radical generation.

Cited by 48 publications

References 27 publications

Cassia tora leaves modulates selenite cataract by enhancing antioxidant status and preventing cytoskeletal protein loss in lenses of Sprague Dawley rat pups

Cassia tora leaves modulates selenite cataract by enhancing antioxidant status and preventing cytoskeletal protein loss in lenses of Sprague Dawley rat pups

Evaluation of the effect of <i>Spathodea campanulata</i> flower bud exudate on cataractogenesis in rat lenses

Small molecules, both dietary and endogenous, influence the onset of lens cataracts

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