<i>MicroRNA‐1254</i> inhibits the migration of colon adenocarcinoma cells by targeting <i>PSMD10</i>

Chu, Yi-Min; Peng, Hai Xia; Xü, Ying; Yang, Da; Zhou, Feng; Li, Ji; Kuai, Rong; Lin, Yong

doi:10.1111/1751-2980.12463

Cited by 15 publications

(14 citation statements)

References 33 publications

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“…Enforced expression of miR-1254 suppressed the migration capacity of colorectal cancan cells by targeting PSMD10, which was an important regulator for epithelial–mesenchymal transition. 17 Similarly, miR-1254 expression was lower in cervical cancer tissues than in adjacent normal tissues. Reduced miR-1254 was positively associated with positive lymphatic invasion, distant metastasis, and advanced International Federation of Gynecology and Obstetrics stage.…”

Section: Discussionmentioning

confidence: 98%

MiR-1254 Functions as a Tumor Suppressor in Oral Squamous Cell Carcinoma by Targeting CD36

Chen

Zhang

2019

Technol Cancer Res Treat

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Oral squamous cell carcinoma is one of the most common cancers around the world. The patients with oral squamous cell carcinoma are often diagnosed at late stages, leading to unfavorable prognosis. MicroRNAs might function as oncogenes or tumor suppressor genes in the tumorigenesis of cancer. This study aimed to explore the role of miR-1254 in oral squamous cell carcinoma. We examined the expression levels of miR-1254 in oral squamous cell carcinoma tissue samples and cell line.Proliferation and invasion assays were performed in oral squamous cell carcinoma cells with miR-1254 overexpression or underexpression. The potential regulatory mechanisms were also explored. We found that miR-1254 was significantly reduced in oral squamous cell carcinoma tissues and cell lines. In addition, downregulation of miR-1254 in oral squamous cell carcinoma tumor tissues was closely associated with cancer staging and lymph node metastasis. Enforced expression of miR-1254 significantly inhibited proliferation and invasion in oral cancer cells, and downregulation of miR-1254 promoted the oncogenic activities of oral cancer cells. CD36 was identified as a direct downstream target of miR-1254 by the luciferase reporter assay. Overexpression of CD36 partially restored the proliferation and invasion capacity inhibited by miR-1254. CD36 expression was inversely correlated with miR-1254 expression in the oral squamous cell carcinoma tissues. Taken together, our study provided the compelling evidence that miR-1254 might inhibit the progression of OSCC by partially downregulating CD36, and restoration of miR-1254 may represent an effective strategy for treating oral squamous cell carcinoma.

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Section: Discussionmentioning

confidence: 98%

MiR-1254 Functions as a Tumor Suppressor in Oral Squamous Cell Carcinoma by Targeting CD36

Chen

Zhang

2019

Technol Cancer Res Treat

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“…It has been shown that miRNAs act as carcinogenic factors or tumor suppressor factors according to the specific function of targeting mRNA 22,23 . Only a few studies have reported miR-1254 is aberrantly expressed and plays special roles in different malignancies like lung cancer, thyroid cancer, and colorectal cancer 11–13 . However, the function of miR-1254 in GC and the potential molecular mechanism remain to be elucidated.…”

Section: Discussionmentioning

confidence: 99%

“…Dysregulation of miRNAs expression promotes the development of cancer due to the activation of oncogenes and silence of tumor-suppressor genes 9,10 . Accumulating evidence has revealed that miR-1254 might strongly correlate to human cancer, such as non-small-cell lung carcinoma, thyroid cancer, and colorectal cancer 11–13 . However, the biological functions and molecular mechanisms of miR-1254 in GC have not been reported.…”

Section: Introductionmentioning

confidence: 99%

miR-1254 inhibits cell proliferation, migration, and invasion by down-regulating Smurf1 in gastric cancer

et al. 2019

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Gastric cancer (GC) is one of the most frequent malignancies, and increasing evidence supports the contribution of microRNA (miRNAs) to cancer progression. miR-1254 has been confirmed to participate in the regulation of various cancers, while the function of miR-1254 in GC remains unknown. In this study, we investigated the role of miR-1254 in GC. The expression of miR-1254 was detected in human GC specimens and cell lines by miRNA RT-PCR. The effects of miR-1254 on GC proliferation were determined by CCK-8 proliferation assays, colony formation assays, 5-ethynyl-2′-deoxyuridine (EdU) incorporation, and cell-cycle assays. The ability of migration and invasion was examined by transwell and wound-healing assay. Dual Luciferase reporter assay was used to validate the interaction of miR-1254 with its target gene. The xenograft mouse models were conducted to investigate the effects of miR-1254 in vivo. The signaling pathways and epithelial–mesenchymal transition (EMT)-related proteins were detected with western blot. The results showed that miR-1254 inhibited the proliferation, migration and invasion in vitro and suppressed tumorigenesis in vivo. Smurf1 was shown to be the direct target of miR-1254. Overexpressing Smurf1 could partially counteract the effects caused by miR-1254. Similarly, the effects of the miR-1254-inhibitor were also rescued by Smurf1-shRNA. Furthermore, we found that miR-1254 inhibited EMT and decreased the PI3K/AKT signaling pathway through downregulating Smurf1. In summary, overexpression of miR-1254 could suppress proliferation, migration, invasion, and EMT via PI3K/AKT signaling pathways by downregulation of Smurf1 in GC, which suggests a potential therapeutic target for GC.

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“…Earlier investigations carried out on miR-1254 have revealed that it inhibited cell migration and invasion of cancer cells [14]. For instance, miR-1254 has been reported to inhibit the migration and invasion of colorectal cancer by inhibiting PSMD10 [15]. Therefore, the effect of miR-1254 on the migration and invasion of SW 1008 astrocytoma cells was also investigated in the current study.…”

Section: Discussionmentioning

confidence: 86%

MiR-1254 inhibits proliferation, migration and invasion of human brain tumour cell lines

Li¹,

Zhao²,

Jiang³

et al. 2018

Trop. J. Pharm Res

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MicroRNA‐1254 inhibits the migration of colon adenocarcinoma cells by targeting PSMD10

Abstract: MiR-1254 may act as a tumor suppressor in CRC and may inhibit CRC migration by directly targeting PSMD10 to suppress the EMT process.

Cited by 15 publications

References 33 publications

MiR-1254 Functions as a Tumor Suppressor in Oral Squamous Cell Carcinoma by Targeting CD36

MiR-1254 Functions as a Tumor Suppressor in Oral Squamous Cell Carcinoma by Targeting CD36

miR-1254 inhibits cell proliferation, migration, and invasion by down-regulating Smurf1 in gastric cancer

MiR-1254 inhibits proliferation, migration and invasion of human brain tumour cell lines

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