Microdosimetry and Its Applications

Abstract

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Microdosimetry: Principles and applications

“…Nowadays, instrumentation for microdosimetry and nanodosimetry covers a great number of devices and techniques, 11 but the classical instrument designed by Rossi and still in use today for characterizing complex radiation fields is the Tissue-Equivalent (spherical) Proportional Counter, or TEPC. It is based on a relationship that, under certain conditions, relates the energy deposited in a gas-filled, centimeter-sized cavity (g) with that actually deposited in a micrometer-sized site of living tissue (t):…”

“…Two different formulations were developed, 11 depending on the need of considering a detailed description of the inchoate distribution of energy deposited by charged particles in a microscopic sensitive volume, or site: Regional microdosimetry (or the microdosimetry of Rossi counters): This approach considers the process of energy deposition in a site of specified dimensions without regard to the microscopic distribution of energy transfers, that is, the "pattern" of ionizations produced by the charged particle trajectory. This formulation is especially important because it involves quantities that can, in principle, be measured and correlated with biological effects.…”

100 Years of Radiation Research in the Footsteps of Failla

“…As a consequence, he was a logical successor to Failla as Director of the RRL. Harald Rossi is best known for his development of the concept of microdosimetry, simulating a volume comparable to the nucleus of a mammalian cell by using a tissue equivalent gas at low pressure (11). Microdosimetry required the design and construction of elaborate measuring devices, the so-called Rossi Counters (Fig.…”

Response of a SOI Microdosimeter to a /sup 238/PuBe Neutron Source

“…The most commonly employed instrumentation type for measurement of the microdosimetric spectra are gas proportional counters [2]. Such instruments are bulky, demand a tissue equivalent (TE) gas supply, and high voltage operation which that make such instruments unsuited for use in personal radiation dosimetry.…”

“…Two different approaches have been suggested for estimation of RBE; the fluence based approach [1], and; the regional microdosimetry approach [2].…”