<i>MEFV</i>gene is a probable susceptibility gene for Behçet's disease

İmirzalıoğlu, Necat; Dursun, Ahmet; Tastan, Bora; Soysal, Yasemin; Yakıcıer, Mustafa Cengiz

doi:10.1080/03009740510017931

Cited by 74 publications

(47 citation statements)

References 9 publications

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“…While some studies report high frequencies of MEFV mutations in BD patients, ranging between 30% and 40.4% [20,21,[82][83][84], some other studies report that these mutations are not increased in BD [85,86]. For convenience, the summary of these studies was given in Table 2.…”

Section: Protracted Febrile Myalgiamentioning

confidence: 98%

Coexistence of vasculitides with Familial Mediterranean Fever

Aksu

Keser

2011

Rheumatol Int

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Familial Mediterranean fever (FMF) is the most common autoinflammatory disease characterized by recurrent self-limited attacks of fever accompanied with peritonitis, pleuritis, or arthritis. FMF may coexist with various systemic inflammatory diseases including vasculitides, spondyloarthritis, multiple sclerosis, and inflammatory bowel disease. Among these coexistences, this review concentrates on vasculitic disorders, with the aim of increasing the awareness of FMF-vasculitis association. This association does not merely show a coincidentally increased frequency of vasculitic disorders in FMF; rather, it seems that FMF patients might be at increased risk of developing vasculitis. Indeed, as also suggested by some authors, vasculitis might be an essential feature of FMF. Among the vasculitic disorders reported to be associated with FMF, Henoch-Schönlein purpura, and classical polyarteritis nodosa come the first, possibly followed up by protracted febrile myalgia. There is also an ongoing debate whether Behçet's disease (BD) more frequently seen in FMF than expected by chance alone. In this review, the associations of various vasculitic disorders with FMF and the possible pathogenic mechanisms underlying these associations, as well as the frequencies and clinical significances of FMF-related MEFV mutations in various vasculitides including BD, are discussed in the context of the available data.

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Section: Protracted Febrile Myalgiamentioning

confidence: 98%

Coexistence of vasculitides with Familial Mediterranean Fever

Aksu

Keser

2011

Rheumatol Int

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“…21,[105][106][107] FMF carriers with Behçet disease have been found to have an increased risk for venous thrombosis. 106 …”

Section: Behçet Diseasementioning

confidence: 99%

Familial Mediterranean fever—A review

Shohat

Halpern

2011

Genetics in Medicine

151

113

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“…В пользу аутовоспалительной природы болезни Бехчета свиде-тельствуют повышение активности нейтрофилов и уровня интерлейкина 1␤ [50], периодические эпизоды ремис-сии и обострения, гиперэкспрессия провоспалительных цитокинов [51]. Более того, имеются сведения, что при болезни Бехчета нередко встречаются некоторые вари-анты гена периодической болезни [52].…”

Section: Discussionunclassified

Juvenile Behсet's Disease: Clinical Observation

Соботюк¹,

Кононов²,

Бочанцев³

et al. 2016

Vopr. sovr. pediatr.

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ВВЕДЕНИЕВерификация воспалительных заболеваний кишеч-ника (ВЗК) представляет для клинициста трудную диаг -ностическую задачу. Это обусловлено схожестью кли-ни ческих симптомов заболеваний кишечника, мно го-образием вариантов клинических проявлений, от сут -ствием определенных этиологических факторов, надеж-ных лабораторных тестов и, в ряде случаев, отличи-тельных гистологических признаков [1]. Встречающиеся наиболее часто в клинической практике врача детского гастроэнтеролога язвенный колит и болезнь Крона даже при использовании современных методов диагностики не всегда удается разграничить. Это обусловлено тем, что у детей, в отличие от взрослых, болезнь Крона чаще ассоциируется с поражением толстого кишечника (коли-том) и в меньшей степени -с илеитом [2]. Биоптаты,

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MEFVgene is a probable susceptibility gene for Behçet's disease

Abstract: The occurrence of frequent MEFV mutations in BD patients suggests that the MEFV gene is involved in the pathogenesis of Behçet's disease.

Cited by 74 publications

References 9 publications

Coexistence of vasculitides with Familial Mediterranean Fever

Coexistence of vasculitides with Familial Mediterranean Fever

Familial Mediterranean fever—A review

Juvenile Behсet's Disease: Clinical Observation

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