<i>Mauritia flexuosa</i>L. protects against deficits in memory acquisition and oxidative stress in rat hippocampus induced by methylmercury exposure

Leão, Luana Ketlen Reis; Herculano, Anderson Manoel; Maximino, Caio; Costa, Alódia Brasil; Gouvêia, Amauri; Batista, Evander O.; Rocha, Fabiana; Crespo-López, María Elena; Borges, Rosivaldo dos Santos; Oliveira, Karen Renata Matos

doi:10.1080/1028415x.2015.1133030

Cited by 19 publications

(14 citation statements)

References 68 publications

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“…In this and previous studies (Shi et al, ; Takeungwongtrakul & Benjakul, ), it was observed that lipid peroxidation in L. vannamei can be reduced by the inclusion of plant antioxidants in the diets. The ability of M. flexuosa fruit pulp to promote the reduction in lipid peroxidation has also been observed in rats by Leão et al ().…”

Section: Discussionmentioning

confidence: 70%

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Inclusion of AmazonianMauritia flexuosafruit pulp as functional feed in the diet for the juvenile Pacific white shrimpLitopenaeus vannamei

et al. 2020

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This study investigated the effects of the inclusion of Mauritia flexuosa fruit pulp in the diet on the growth performance, economic benefit, muscle composition, total contents of carotenoids and flavonoids, chromaticity parameters, total antioxidant capacity, and lipid peroxidation in the hepatopancreas and muscle of the juvenile shrimp Litopenaeus vannamei (weighing 1.26 ± 0.023 g). Five diets (37% protein, 10% lipid) consisting of 0 (control), 1.25%, 2.50%, 5.00% and 10.00% (w/w) M. flexuosa fruit pulp were formulated and provided to the shrimps (n = 50 per tank, treatments in triplicate) for 31 days. Results showed that there were no significant differences between the treatments in terms of the growth capacity, chromaticity parameters, muscle composition and total flavonoid content of shrimps (p > .05). However, the carotenoid content in the muscle and hepatopancreas of the shrimps was significantly increased due to the dietary carotenoids present in M. flexuosa fruit pulp (p < .05). This increase in the carotenoid content directly favoured the increase in the antioxidant capacity in the hepatopancreas and muscle of the shrimps (R2 = 0.99 and R2 = 0.97 respectively; p < .05). There was also a direct relationship between the carotenoid content and the decrease in lipid peroxidation in the hepatopancreas (R2 = 0.90; p < .05). The feed cost kg−1 in terms of weight gain and protein production decreased with the inclusion of high levels of M. flexuosa fruit pulp, reaching 8.11% and 18.76% of cost reduction, respectively, with the addition of 5.00% of M. flexuosa fruit pulp. Therefore, the inclusion of M. flexuosa fruit pulp in the diets of shrimp can increase the carotenoid content and the antioxidant capacity in the hepatopancreas and muscle, reduce lipid peroxidation in the hepatopancreas, and probably provide economic benefits for the rearing of juvenile shrimps.

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Section: Discussionmentioning

confidence: 70%

“…flexuosa fruit pulp to promote the reduction in lipid peroxidation has also been observed in rats by Leão et al (2016). (Kumar et al, 2016).…”

Section: Discussionmentioning

confidence: 95%

Inclusion of AmazonianMauritia flexuosafruit pulp as functional feed in the diet for the juvenile Pacific white shrimpLitopenaeus vannamei

et al. 2020

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“…Indeed, there is a strong correlation between thiobarbituric acid-reactive substances (TBARS) as a marker of lipid peroxidation and products that protect cells against oxidative damage [ 50 ]. Such protection can explain, at least in part, some folk uses and pharmacological properties of these fruits, such as protective effects against cognitive impairment [ 24 , 62 ], antiplatelet, antithrombotic [ 63 ], lowering cholesterol [ 43 , 64 ], and healing [ 19 , 41 ] activities.…”

Section: Discussionmentioning

confidence: 99%

In Vitro and Ex Vivo Chemopreventive Action of Mauritia flexuosa Products

Pereira-Freire

Oliveira

Lima

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Mauritia flexuosa (Arecaceae), known as “Buriti,” is a Brazilian palm tree with high economic potential for local communities. Herein, we investigated the phytochemistry profile and antioxidant potential of M. flexuosa fruits and determined the bioaccessibility of phenolic compounds. Peels revealed upper values for phenols, flavonoids, carotenoids, tannins, and ascorbic acid when compared to the pulps and endocarps. All samples showed capacity to scavenger free radicals (0.5, 1.0, 2.0, 4.0, and 8.0 mg/mL) but peels presented higher scavenger action in all methods explored. Phenolic compounds identified by HPLC displayed reduced bioaccessibility after in vitro simulated gastrointestinal digestion for pulp (38.7%), peel (18.7%), and endocarp (22.3%) extracts (P < 0.05). Buriti fruits also protected rat blood cells against lysis induced by peroxyl radicals. We demonstrated the promising chemopreventive potentialities of M. flexuosa fruits and their by-products and peels with higher quantities of bioactive compounds and phenolic substances before and after in vitro bioaccessibility investigation. In Brazil, these parts are discarded or underused, mainly as feed for ruminant animals. Consequently, it is extremely important to explore nutritional characteristics of these by-products for human/livestock foods and to install biofriendly techniques and sustainable biotechnology handling of natural resources.

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“…Moreover, it was hypothesized that the consumption of Amazonian fruits would protect exposed populations, reducing the accumulation of mercury in humans [19]. Despite of that, studies with Amazonian fruits and MeHg intoxication are relatively scarce, being mainly limited to fruits such as guaraná, maná-cubiu, burití and açaí [20,21,22,23,24]. Although guaraná ( Paullinia cupana , Mart.)…”

Section: Introductionmentioning

confidence: 99%

Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí (Euterpe oleracea, Mart.) as Juice for Human Consumption

et al. 2019

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Methylmercury (MeHg) exposure is a serious problem of public health, especially in the Amazon. Exposure in riverine populations is responsible for neurobehavioral abnormalities. It was hypothesized that consumption of Amazonian fruits could protect by reducing mercury accumulation. This work analyzed the effects of commercial samples of Euterpe oleracea (EO) for human consumption (10 μL/g) against MeHg i.p. exposure (2.5 mg/Kg), using neurobehavioral (open field, rotarod and pole tests), biochemical (lipid peroxidation and nitrite levels), aging-related (telomerase reverse transcriptase (TERT) mRNA expression) and toxicokinetic (MeHg content) parameters in mice. Both the pole and rotarod tests were the most sensitive tests accompanied by increased lipid peroxidation and nitrite levels in brains. MeHg reduced TERT mRNA about 50% demonstrating a strong pro-aging effect. The EO intake, similar to that of human populations, prevented all alterations, without changing the mercury content, but avoiding neurotoxicity and premature aging of the Central Nervous System (CNS). Contrary to the hypothesis found in the literature on the possible chelating properties of Amazonian fruits consumption, the effect of EO would be essentially pharmacodynamics, and possible mechanisms are discussed. Our data already support the regular consumption of EO as an excellent option for exposed Amazonian populations to have additional protection against MeHg intoxication.

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Mauritia flexuosaL. protects against deficits in memory acquisition and oxidative stress in rat hippocampus induced by methylmercury exposure

Abstract: Therefore, this study suggests that Mauritia flexuosa L. represents an important strategy to prevent neurocytotoxics and behavioral effects of MeHg.

Cited by 19 publications

References 68 publications

Inclusion of AmazonianMauritia flexuosafruit pulp as functional feed in the diet for the juvenile Pacific white shrimpLitopenaeus vannamei

Inclusion of AmazonianMauritia flexuosafruit pulp as functional feed in the diet for the juvenile Pacific white shrimpLitopenaeus vannamei

In Vitro and Ex Vivo Chemopreventive Action of Mauritia flexuosa Products

Towards Therapeutic Alternatives for Mercury Neurotoxicity in the Amazon: Unraveling the Pre-Clinical Effects of the Superfruit Açaí (Euterpe oleracea, Mart.) as Juice for Human Consumption

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