<i>Malassezia sympodialis</i> differently affects the expression of LL‐37 in dendritic cells from atopic eczema patients and healthy individuals

Agerberth, Birgitta; Buentke, Eva; Bergman, Peter; Eshaghi, Hojjat; Gabrielsson, Susanne; Guðmundsson, Guðmundur H.; Scheynius, Annika

doi:10.1111/j.1398-9995.2005.00952.x

Cited by 17 publications

(5 citation statements)

References 35 publications

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“…Secretion from bone marrow is believed to be the major contributor of hCAP18 in blood (about 1.2 µg/ml), which is higher than many other specific granule proteins in the serum [122]. To a lesser extent, other immune cells including macrophages [22], dendritic cells [123], mast cells [124], monocyte, natural killer cells, γδ T cells and B cells [125] all produce CAMP. A hierarchy of expression exists in peripheral blood cells with neutrophils expressing the most hCAP18, monocytes the next most and lymphocytes the least [126].…”

Section: The Effect Of Vitamin D On Human Cathelicidin Expressionmentioning

confidence: 99%

The Antibiotic Effects of Vitamin D

Guo¹,

Gombart

2014

EMIDDT

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The recent discovery that vitamin D regulates expression of the cathelicidin antimicrobial peptide gene has generated renewed interest in using vitamin D to fight infectious diseases. This review describes the historical use of vitamin D or its sources to treat infections, the mechanism of action through which vitamin D mediates its "antibiotic" effects, findings from epidemiological studies associating vitamin D deficiency with increased susceptibility to infection and clinical trials with vitamin D supplementation to treat or prevent infections. Further studies examining an association between vitamin D levels and cathelicidin expression are discussed. The role of cathelcidin throughout the course of infection from the initial encounter of the pathogen to the resolution of tissue damage and inflammation indicates that individuals need to maintain adequate levels of vitamin D for an optimal immune response. In addition, for treating infections, carefully designed randomized, clinical trials that are appropriately powered to detect modest effects, target populations that are severely deficient in vitamin D,and optimized dose, dosing frequency and safety are needed.

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Section: The Effect Of Vitamin D On Human Cathelicidin Expressionmentioning

confidence: 99%

The Antibiotic Effects of Vitamin D

Guo¹,

Gombart

2014

EMIDDT

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“…LL-37/ human cathelicidin antimicrobial peptide 18 (hCAP-18), the human antimicrobial peptide of the cathelicidin family, which is normally expressed in epithelia of various organs [77] and neutrophils [78,79], modulates the phenotype and function of DCs [80,81]. Identification of LL-37/hCAP-18 expression by DCs [82] and recent findings that LL-37 modulate epithelial responses, which are described below, indicate that LL-37 might mediate interactions between ECs and DCs. Also ␤-defensins are implicated in the chemoattraction of immune cells such as DCs [83].…”

Section: Ec-dcmentioning

confidence: 99%

Interactions between epithelial cells and leukocytes in immunity and tissue homeostasis

Shaykhiev

Bals

2007

Journal of Leukocyte Biology

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Epithelial cells (ECs) cover the surfaces of the body such as skin, airways, or the intestinal tract and provide an important link between the outside environment and the body interior. Leukocytes play a critical role in immunity, as they are the predominant cell population involved in inflammation and the only cells providing adaptive immune response to pathogenic microorganisms. ECs and leukocytes form a complex network, which regulates processes such as host defense, immunity, inflammation, tissue repair, and cancer growth. One of the most critical functions of ECs is to keep up a barrier to the outside and to protect the sensitive immune system from continuous contact with external microorganisms. An appropriate response to wounding or danger involves not only killing of microbes but also regulation of tissue repair and reconstitution of the barrier system. Dysregulated response to damage represents a pathophysiological mechanism, which leads to autoimmunity, chronic inflammatory diseases, and cancer development. The networks described here are involved in virtually all diseases that take place at body surfaces. In this article, we develop a concept of epithelial barrier as a critical regulator of leukocyte function and discuss how host defense processes modulate epithelial homeostasis.

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“…In support of this concept, M. sympodialis has been shown to differently affect the level of antimicrobial components secreted by dendritic cells (in particular the cathelicidin LL-37) from patients with AD compared to dendritic cells isolated from healthy volunteers [48]. These data support the concept that Malassezia-activated dendritic cells may contribute to the allergic state, and a better understanding of the underpinning molecular mechanisms will be useful in the design of novel immunotherapeutic and anti-microbial strategies.…”

Section: Novel Immunotherapeutic Approaches For Allergy 495mentioning

confidence: 80%

Novel immunotherapeutic approaches for allergy and asthma

2010

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The immune response is a tightly regulated process, which normally results in protection from infection and tolerance of innocuous environmental antigens. However, in allergic disease, the activated immune response results in a chronic pro-inflammatory state characterized by antibody secretion (IgE) and T cell activation to normally well-tolerated antigens. Currently, the treatment of allergic disease is focused on the suppression of key inflammatory mediators or inflammatory cell populations and include anti-histamines, anti-leukotrienes, β2 adrenergic receptor agonists and corticosteroids. However, these approaches only provide a temporary suppression of disease symptoms. Successful long-term treatment can only be provided by allergen-specific immunotherapy (allergen-SIT), which restores normal immunity against allergens. This review will discuss novel approaches to the management of allergy and asthma by targeting the T regulatory cell via modulation of the commensal microbiota and allergen-SIT.

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Malassezia sympodialis differently affects the expression of LL‐37 in dendritic cells from atopic eczema patients and healthy individuals

Abstract: Our results suggest that M. sympodialis can trigger the innate immune response differently in patients with AE and healthy individuals. The enhanced LL-37 secretion from the MDDCs in the patients with AE may reflect the severity of their inflammatory response to M. sympodialis.

Cited by 17 publications

References 35 publications

The Antibiotic Effects of Vitamin D

The Antibiotic Effects of Vitamin D

Interactions between epithelial cells and leukocytes in immunity and tissue homeostasis

Novel immunotherapeutic approaches for allergy and asthma

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