<i>Lycium barbarum</i> Polysaccharide Extracted from <i>Lycium barbarum</i> Leaves Ameliorates Asthma in Mice by Reducing Inflammation and Modulating Gut Microbiota

Cui, Fang; Shi, Chunwei; Zhou, Xiaojing; Wang, Wen; Gao, Xiaoping; Wang, Liying; He, Bin; Yin, Mei; Zhao, Jiaqing

doi:10.1089/jmf.2019.4544

Cited by 38 publications

(23 citation statements)

References 36 publications

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“…[11][12][13] A growing number of studies have recognized that plant polysaccharides are natural flora regulators, and they can enhance systemic immune function by regulating gut microbiota. [14][15][16] Astragalus polysaccharides (APS), the main effective component of Astragalus membranaceus, can enhance immune function and inhibit tumor growth.…”

Section: Introductionmentioning

confidence: 99%

Immunosuppressive activity is attenuated by Astragalus polysaccharides through remodeling the gut microenvironment in melanoma mice

Ding

Gong

et al. 2021

Cancer Science

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Section: Introductionmentioning

confidence: 99%

Immunosuppressive activity is attenuated by Astragalus polysaccharides through remodeling the gut microenvironment in melanoma mice

Ding

Gong

et al. 2021

Cancer Science

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“…L) is a deciduous shrub plant belonging to the family Solanaceae, which is also known as Goji Berry [1]. Being the conventional Chinese medicinal herb for over 2000 years now, wolfberry fruits contain a variety of bioactive substances such as L. barbarum polysaccharide [2], carotenoids, betaine, vitamins, and cerebroside bioactive substances that have now been recognized as the latest “superfruit” in the world [3]. Because wolfberry fruits have a thin peel, high water content, and high sugar content, they rot easily after harvest.…”

Section: Introductionmentioning

confidence: 99%

The inhibitory effect of volatile organic compounds produced by Bacillus subtilis CL2 on pathogenic fungi of wolfberry

Ling

Zhao

et al. 2020

J Basic Microbiol

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Bacillus subtilis strain CL2 is antagonistic to wolfberry postharvest pathogenic fungi. In this study, we isolated and screened this strain for in vitro experiments. The result of the two-sealed-base-plates method revealed that volatile organic compounds (VOCs) emitted from the strain CL2 inhibited the hyphal growth of four pathogenic fungi Mucor circinelloides LB1, Fusarium arcuatisporum LB5, Alternaria iridiaustralis LB7, and Colletotrichum fioriniae LB8. After exposure to VOCs for 5 days, the hyphal growth of the pathogen C. fioriniae LB8 was inhibited by 73%. Scanning electron microscopy revealed that the VOCs produced by B. subtilis CL2 caused the mycelium morphology of the pathogenic fungi to deform, twist, fold, and shrink. In the in vivo experiments, we noticed that VOCs could significantly reduce the weight loss rate of wolfberry fruits caused by the pathogenic fungus M. circinelloides LB1 and that the decay incidence rate were caused by the pathogenic fungi F. arcuatisporum LB5, A. iridiaustralis LB7, and C. fioriniae LB8. On the basis of the headspace-gas chromatography-ion mobility spectrometry analysis, seven VOCs produced by strain CL2 were identified. Among them, 2,3-butanedione and 3-methylbutyric acid are the main antifungal active substances. This study investigated the antifungal properties of VOCs produced by the strain CL2 on postharvest pathogenic fungi isolated from wolfberry fruits both in vivo and in vitro, thereby providing the theoretical basis for its future applications. K E Y W O R D S antifungal activity, Bacillus subtilis CL2, HS-GC-IMS, volatile organic compounds (VOCs), wolfberry 1 | INTRODUCTION Wolfberry (Lycium barbarum. L) is a deciduous shrub plant belonging to the family Solanaceae, which is also known as Goji Berry [1]. Being the conventional Chinese medicinal herb for over 2000 years now, wolfberry fruits contain a variety of bioactive substances such as L. barbarum polysaccharide [2], carotenoids, betaine, vitamins, and cerebroside bioactive substances that have now been recognized as the latest "superfruit" in the world [3]. Because

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“…Thus, TNF-α could serve as an inflammatory biomarker of DED. Meanwhile, the mechanism of the anti-inflammatory effects of LBP in many systemic diseases was found to be related to TNF-α and its upstream and downstream pathways ( 9 , 10 , 28 , 29 ). In our study, the expression of TNF-α in the cornea significantly increased in the murine DED model, and decreased after the treatment of HLBP.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effects of Topical Application of Lycium barbarum Polysaccharide in a Murine Model of Dry Eye

et al. 2022

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PurposeTo evaluate the safety and efficacy of Lycium barbarum polysaccharide (LBP) eye drops in a murine model of dry eye disease (DED).MethodsSix- to eight-week-old female C57BL/6 mice were subjected to a combination of desiccating stress (DS) and topical benzalkonium chloride (BAC) to induce DED. Five microliters of LBP eye drops (0.625, 2.5, or 12.5 mg/ml) or PBS was applied topically 3 times per day for 10 days to subsequently test their efficacy. Tear secretion, tear breakup time (TBUT), corneal irregularity, and corneal fluorescein staining scores were measured on days 3 and 10 after treatment. The expression of tumor necrosis factor-alpha (TNF-α) in the cornea was assessed by quantitative (q) RT–PCR on days 10. The ocular irritation of LBP eye drops of corresponding concentrations was evaluated on 10- to 12-week-old female Sprague–Dawley rats.ResultsCompared with PBS-treated groups, mice treated with 0.625, 2.5, and 12.5 mg/ml LBP showed a significant improvement in the clinical signs of DED in a dose-dependent manner, including corneal epithelial integrity, corneal regularity, and tear production, as well as significant inhibition of inflammatory cell infiltration and TNF-α expression levels in the cornea. All corresponding concentrations of LBP eye drops revealed no obvious ocular irritation.ConclusionTopical application of LBP could ameliorate dry eye in a murine model of DED without obvious ocular irritation.

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Lycium barbarum Polysaccharide Extracted from Lycium barbarum Leaves Ameliorates Asthma in Mice by Reducing Inflammation and Modulating Gut Microbiota

Cited by 38 publications

References 36 publications

Immunosuppressive activity is attenuated by Astragalus polysaccharides through remodeling the gut microenvironment in melanoma mice

Immunosuppressive activity is attenuated by Astragalus polysaccharides through remodeling the gut microenvironment in melanoma mice

The inhibitory effect of volatile organic compounds produced by Bacillus subtilis CL2 on pathogenic fungi of wolfberry

Therapeutic Effects of Topical Application of Lycium barbarum Polysaccharide in a Murine Model of Dry Eye

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