Highlights d DHX15 senses RNA viruses to produce IFN-b, IFN-l3, and IL-18 in IECs d IEC-specific Dhx15-knockout mice are generated d DHX15 is required for controlling RNA virus-induced intestinal inflammation in vivo d DHX15 interacts with NLRP6 to trigger inflammasome activation in IECs
Abstract. serves an important role in regulating growth, invasiveness, stem cell-like traits, differentiation and apoptosis of different types of tumor cells.
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