<i>Lncrna Neat1</i>
            Correlates with TH1 and TH17 and Could Serve as an Assistant Biomarker in Sepsis

Liu, Bo; Ren, Haibo; Chen, Jing

doi:10.2217/bmm-2020-0906

Cited by 6 publications

(3 citation statements)

References 25 publications

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“…As a result, lncRNA NEAT1 is a possible applicable biomarker for sepsis. 36 Since lncRNA NEAT1 overexpression has been demonstrated in the peripheral blood mononuclear cells (PBMC) sample of RA patients, lncRNA NEAT1 knockdown prevents the differentiation of CD4+ T cells towards Th17 by decreasing the STAT3 protein level, a pivotal molecule for Th17 differentiation and a downstream target for NEAT1. 37 LncRNA NEAT1 upregulation has been reported in the CD4+ T cells of peripheral blood samples from patients with preeclampsia (PE).…”

Section: Neat1mentioning

confidence: 99%

Regulatory Effects of Long Non-coding RNAs on Th17/Treg Differentiation and Imbalance

Dabbaghipour,

Ahmadi,

Entezam

et al. 2024

IJAAI

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Scientific research over the past decades has proven the pivotal role of long non-coding RNAs (LncRNAs) in regulating gene expression. The immune responses are controlled through the interaction of pro-inflammatory (predominance of T helper 17 cells (Th17)) and anti-inflammatory cytokines excretion (predominance of Regulatory T cells (Treg)). Recent studies have marked the impact of many diverse LncRNAs on Treg/Th17 imbalances. Moreover, some of the roots and causes of human diseases can be associated with the alterations in the Th17/Treg ratio. In this review study, we overviewed the association between LncRNAs and Th17/Treg, with the potential of providing novel prognostic and diagnostic biomarkers and promising therapeutic targets in various diseases, particularly cancer.

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Section: Neat1mentioning

confidence: 99%

Regulatory Effects of Long Non-coding RNAs on Th17/Treg Differentiation and Imbalance

Dabbaghipour,

Ahmadi,

Entezam

et al. 2024

IJAAI

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“… 25 The LncRNA NEAT1 can be used as a combined biomarker in patients with sepsis. 84 RNA-Seq (RNA sequencing technology) study based on the expression profile of endotoxin-responsive LncRNA in human microvascular endothelial cells found that LncRNA EGO and HOTAIRM1 were heterogeneously expressed at 3 h, while LNC-IL7R was significantly upregulated at 24 h. 26 All these suggest the feasibility of lncRNAs as diagnostic biomarkers for urosepsis. In addition, quantitative polymerase chain reaction (QPCR) can rapidly quantify lncRNAs in patient blood in a shorter time than bacterial culture, which is an advantage of lncRNAs as biomarkers for urosepsis.…”

Section: Other Markersmentioning

confidence: 99%

Diagnostic and therapeutic value of biomarkers in urosepsis

Wang

Huang

et al. 2023

Therapeutic Advances in Urology

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Urosepsis is sepsis caused by urogenital tract infection and is one of the most common critical illnesses in urology. If urosepsis is not diagnosed early, it can rapidly progress and worsen, leading to increased mortality. In recent years, with the increase of urinary tract surgery, the incidence of urosepsis continues to rise, posing a serious threat to patients. Early diagnosis of urosepsis, timely and effective treatment can greatly reduce the mortality of patients. Biomarkers such as WBC, NLR, PCT, IL-6, CRP, lactate, and LncRNA all play specific roles in the early diagnosis or prognosis of urosepsis. In addition to the abnormal increase of WBC, we should be more alert to the rapid decline of WBC. NLR values were superior to WBC counts alone in predicting infection severity. Compared with several other biomarkers, PCT values can differentiate between bacterial and non-bacterial sepsis. IL-6 always has high sensitivity and specificity for the diagnosis of sepsis, and CRP also has high sensitivity and specificity for the diagnosis of urosepsis. Lactic acid is closely related to the prognosis of patients with urosepsis. LncRNAs may be potential biomarkers of urosepsis. This article summarizes the main biomarkers, hoping to provide a reference for the timely diagnosis and evaluation of urosepsis.

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“…In rats, NEAT1 knockdown could significantly improve the sepsis-induced myocardial injury preventing cardiac insufficiency and consensually increasing the ejection fraction ( p < 0.05) [ 97 ]. Furthermore, another study indicates that NEAT1 inhibits the LPS-induced progression of sepsis in RAW264.7 cells by modulating the miR-31-5p/POU2F1 axis [ 98 ], suggesting that NEAT1, which also positively correlates with Th1 and Th17 levels [ 99 ], will be a potential target for clinical treatment of sepsis-induced organ damage.…”

Section: Non-coding Rna and Sepsismentioning

confidence: 99%

Non-Coding RNA Networks as Potential Novel Biomarker and Therapeutic Target for Sepsis and Sepsis-Related Multi-Organ Failure

et al. 2022

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According to “Sepsis-3” consensus, sepsis is a life-threatening clinical syndrome caused by a dysregulated inflammatory host response to infection. A rapid identification of sepsis is mandatory, as the extent of the organ damage triggered by both the pathogen itself and the host’s immune response could abruptly evolve to multiple organ failure and ultimately lead to the death of the patient. The most commonly used therapeutic strategy is to provide hemodynamic and global support to the patient and to rapidly initiate broad-spectrum empiric antibiotic therapy. To date, there is no gold standard diagnostic test that can ascertain the diagnosis of sepsis. Therefore, once sepsis is suspected, the presence of organ dysfunction can be assessed using the Sepsis-related Organ Failure Assessment (SOFA) score, although the diagnosis continues to depend primarily on clinical judgment. Clinicians can now rely on several serum biomarkers for the diagnosis of sepsis (e.g., procalcitonin), and promising new biomarkers have been evaluated, e.g., presepsin and adrenomedullin, although their clinical relevance in the hospital setting is still under discussion. Non-codingRNA, including long non-codingRNAs (lncRNAs), circularRNAs (circRNAs) and microRNAs (miRNAs), take part in a complex chain of events playing a pivotal role in several important regulatory processes in humans. In this narrative review we summarize and then analyze the function of circRNAs-miRNA-mRNA networks as putative novel biomarkers and therapeutic targets for sepsis, focusing only on data collected in clinical settings in humans.

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Lncrna Neat1 Correlates with TH1 and TH17 and Could Serve as an Assistant Biomarker in Sepsis

Cited by 6 publications

References 25 publications

Regulatory Effects of Long Non-coding RNAs on Th17/Treg Differentiation and Imbalance

Regulatory Effects of Long Non-coding RNAs on Th17/Treg Differentiation and Imbalance

Diagnostic and therapeutic value of biomarkers in urosepsis

Non-Coding RNA Networks as Potential Novel Biomarker and Therapeutic Target for Sepsis and Sepsis-Related Multi-Organ Failure

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