<i>Licania rigida</i> leaf extract: Protective effect on oxidative stress, associated with cytotoxic, mutagenic and preclinical aspects

Batista, Débora; Luz, Jefferson Romáryo Duarte da; Nascimento, Thayse Evellyn Silva do; Lopes, Tiago Felipe de Senes; Galdino, Ony Araújo; Silva, Saulo Victor E; Ferreira, Macelia Pinheiro; Azevedo, Marcelo Arrison dos Santos; Brandão-Neto, José; Araújo-Silva, Gabriel; López, Jorge A.; Almeida, Maria das Graças

doi:10.1080/15287394.2021.2002744

Cited by 9 publications

(4 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition to synergism, the chemical compositions of AELR and HELR display concurrent antioxidant activity, which is attributed to the presence of polyphenols. This activity was previously described by Morais et al [ 16 ] and Batista et al [ 32 ], who showed high scavenging free radical DPPH capacities and reductions in lipid peroxidation by HELR and AELR, respectively. Overall, examination of these antioxidant parameters indicates potential protective effects.…”

Section: Discussionsupporting

confidence: 78%

“…No cytotoxic effects of AELR and HELR were observed on cell viability using the Alamar Blue and MTT assays. Furthermore, previous studies by our group with AELR indicated no toxic effects, as evidenced by acute toxicity, 28-day repeated dose oral toxicity, cytotoxicity, and mutagenicity [ 32 ]. Regarding the hydroethanolic leaf extract, Morais et al [ 16 ] reported no toxicity in animals, no cytotoxicity, and nonsignificant apoptotic levels.…”

Section: Discussionmentioning

confidence: 95%

“…Many plant species have toxic constituents that are responsible for triggering hepato- and renal toxic effects, abortion, and poisoning [ 28 , 29 , 30 , 31 ]. However, Luz et al [ 24 ] and Batista et al [ 32 ] showed no toxic, cytotoxic, or genotoxic effects when using alcoholic and aqueous leaf extracts of L. rigida in vivo or in vitro. Therefore, the use of these extracts is promising and appear safe from a toxicological perspective.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mass Spectrometric Identification of Licania rigida Benth Leaf Extracts and Evaluation of Their Therapeutic Effects on Lipopolysaccharide-Induced Inflammatory Response

et al. 2022

Self Cite

View full text Add to dashboard Cite

Licania rigida Benth has been evaluated as an alternative drug to treat diseases associated with inflammatory processes. This study evaluated the anti-inflammatory effects of aqueous and hydroalcoholic leaf extracts of L. rigida with inflammation induced by lipopolysaccharides in in vitro and in vivo inflammation models. The phytochemical profile of the extracts, analyzed by ultra-fast liquid chromatography coupled with tandem mass spectrometry, revealed the presence of gallic and ellagic acids in both extracts, whereas isovitexin, ferulate, bulky amino acids (e.g., phenylalanine), pheophorbide, lactic acid, and pyridoxine were detected in the hydroalcoholic extract. The extracts displayed the ability to modulate in vitro and in vivo inflammatory responses, reducing approximately 50% of pro-inflammatory cytokine secretion (TNF-α, IL-1β, and IL-6), and inhibiting both NO production and leukocyte migration by approximately 30 and 40% at 100 and 500 µg/mL, respectively. Overall, the results highlight and identify, for the first time, the ability of L. rigida leaf extract to modulate inflammatory processes. These data suggest that the leaf extracts of this plant have potential in the development of herbal formulations for the treatment of inflammation.

show abstract

Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mass Spectrometric Identification of Licania rigida Benth Leaf Extracts and Evaluation of Their Therapeutic Effects on Lipopolysaccharide-Induced Inflammatory Response

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…64 Batista et al also showed that there was no genotoxic/mutagenic effect caused by Licania rigida (family: Chrysobalanaceae) leaf aqueous extract (5, 10 or 20 mg mL −1 ) compared to negative (treated with distilled water) and positive (treated with doxorubicin) controls of SMART. 65…”

Section: Smart Resultsmentioning

confidence: 99%

Cytoprotective, antimutagenic/antirecombinogenic and antibacterial properties of Lallemantia iberica extracts

et al. 2022

View full text Add to dashboard Cite

BACKGROUND Plants have important chemical compounds to protect organisms from many mutagens but they may also have dangerous toxic substances that must be tested before use. Lallemantia iberica has been used by local people for treatment of some diseases but it was never tested for its cell protective and antimutagenic/antirecombinogenic properties. In this study, it was aimed to determine the cytoprotective, antimutagenic/antirecombinogenic, antibacterial, antioxidant and phenolic profile of L. iberica by MTS assay, micronucleus test/somatic mutation recombination test (SMART), disc diffusion method, ABTS/DPPH tests and liquid chromatography (LC), respectively. RESULTS MTS assay results showed that both of the extracts supported the normal growth of healthy human lymphocytes and there was no significant difference between extracts. Although there was no significant increase in micronucleus concentration (‰) of the cultures treated with ethanol or methanol extracts, methanol extract caused slightly lower micronucleus concentration (12.64 ± 3.65‰) than the ethanol extract (24.46 ± 4.50‰). SMART results showed that ethanol and methanol extracts prevented harmful mitotic recombination. Lallemantia iberica also showed antibacterial activity against all of the strains tested, and the largest inhibition zones were observed with Pseudomonas aeruginosa (17.9 mm) and Enterobacter aerogenes (13.8 mm). Methanol extracts showed better antioxidant activities (ABTS IC50: 104.07 μg mL−1, DPPH IC50: 58.8 μg mL−1) than ethanol extracts (ABTS IC50: 344.03 μg mL−1, DPPH IC50: 233.7 μg mL−1). According to the LC results, the most abundant phenolic compounds were rutin hydrate (1796.4 ± 62.9 mg kg−1) and p‐coumaric acid (228.1 ± 7.60 mg kg−1). CONCLUSION Lallemantia iberica extracts had cell‐protective, antimutagenic/antirecombinogenic, antibacterial and strong antioxidant characteristics in relation to their rich phenolic content. © 2022 Society of Chemical Industry.

show abstract

Toxicity of methylparaben and its chlorinated derivatives to Allium cepa L. and Eisenia fetida Sav.

Nascimento

Düsman

Gonzalez

et al. 2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

Licania rigida leaf extract: Protective effect on oxidative stress, associated with cytotoxic, mutagenic and preclinical aspects

Cited by 9 publications

References 64 publications

Mass Spectrometric Identification of Licania rigida Benth Leaf Extracts and Evaluation of Their Therapeutic Effects on Lipopolysaccharide-Induced Inflammatory Response

Mass Spectrometric Identification of Licania rigida Benth Leaf Extracts and Evaluation of Their Therapeutic Effects on Lipopolysaccharide-Induced Inflammatory Response

Cytoprotective, antimutagenic/antirecombinogenic and antibacterial properties of Lallemantia iberica extracts

Toxicity of methylparaben and its chlorinated derivatives to Allium cepa L. and Eisenia fetida Sav.

Contact Info

Product

Resources

About