LFG : An anti-apoptotic gene that provides protection from Fas-mediated cell death

Abstract

Programmed cell death regulates a number of biological phenomena, and the apoptotic signal must itself be tightly controlled to avoid inappropriate cell death. We established a genetic screen to search for molecules that inhibit the apoptotic signal from the Fas receptor. Here we report the isolation of a gene, LFG, that protects cells uniquely from Fas but not from the mechanistically related tumor necrosis factor ␣ death signal. LFG is widely distributed, but remarkably is highly expressed in the hippocampus. LFG can bind to the Fas receptor, but does not regulate Fas expression or interfere with binding of an agonist antibody. Furthermore LFG does not inhibit binding of FADD to Fas.

Antiapoptotic protein Lifeguard is required for survival and maintenance of Purkinje and granular cells

“…Lifeguard (LFG) is an antiapoptotic protein that antagonizes the Fas pathway (10). Its transcripts and protein are strongly upregulated during postnatal brain development (11,12) and are highly expressed in PCs and CGNs, suggesting a role in development and/or survival of these neurons.…”

Microarray‐based genomic profiling reveals novel genomic aberrations in follicular lymphoma which associate with patient survival and gene expression status

“…a minimally gained region on 12q13 affecting FAIM2 which protects cells uniquely from FAS mediated death signaling, (Somia et al, 1999) ii. a deletion on 10q24 resulting in a monoallelic loss of FAS, iii.…”

KRT13, FAIM2 and CYP2W1 mRNA Expression in Oral Squamous Cell Carcinoma Patients with Risk Habits

“…In the present study, FAIM2 found to be down-regulated in OSCC. The high expression of LFG was found in the hippocampus and mostly in the neuron cells (Somia et al, 1999). Reich et al (2011) found that loss of FAIM2 will result in enhanced vulnerability to cerebral ischemia with increased neuronal cell death, ischemic lesion volume, and neurological impairment.…”