Lactococcus lactis KR-050L inhibit IL-6/STAT3 activation

Abstract

This study constitutes the first attempt to isolate various LABs from Gajuknamu kimchi and to discover IL-6/STAT3 inhibitors in the EtOAc extract of Lc. lactis KR-050L culture broth. Moreover, our data provide useful biochemical information regarding the commercialization of Lc. lactis isolated from Gajuknamu kimchi as an approach to use functional foods for the treatment of various diseases via IL-6/STAT3 activation.

Lactococcus lactisKR-050L extract suppresses house dust mite induced-atopic skin inflammation through inhibition of keratinocyte and mast cell activation

“…Kimchi is a rich source of LAB, and functional and biological properties of LABs isolated from kimchi (Chinese cabbage kimchi, cubed radish kimchi and young radish kimchi) have been investigated (Hwang et al . ). Previously, we screened six new strains from Gajuknamu kimchi.…”

“…Among the isolated LABs, the extract of culture broth (cells + supernatant) of L. lactis KR‐050L (LLK), exerts the most potent anti‐inflammatory effects compared to the other isolated LABs (Hwang et al . ). Thus, we examined the effects of LLK on atopic skin inflammation using in vitro and in vivo models.…”

“…LLK was prepared as described previously (Hwang et al . ). DFE (Greer Laboratories, Lenoir, NC) was used as an antigen.…”

“…Previously, we showed that the extract of culture broth (cells + supernatant) of Lactococcus lactis KR‐050L (LLK), a newly isolated LAB from Gajuknamu kimchi, exerts anti‐inflammatory effects by the reduction in interleukin (IL)‐6/signal transducer and activator of transcription (STAT)3 pathway, which is also known to play an important role in AD (Hwang et al . ; Ryu et al . ).…”

Diketopiperazines from Rhabdastrella globostellata

“…@ δ C of cyclo‐(L‐Pro‐L‐Ile) [ 8 ] ; # δ C of cyclo‐(L‐Pro‐L‐Leu) [ 9 ] ; $ δ C of cyclo‐(D‐Pro‐L‐Ile). [ 10 ]…”