<i>Lactobacillus rhamnosus</i> zz-1 exerts preventive effects on chronic unpredictable mild stress-induced depression in mice <i>via</i> regulating the intestinal microenvironment

Xu, Jingyun; Tang, Mengqi; Wu, Xinyu; Kong, Xiangli; Liu, Yini; Xu, Xiaoxin

doi:10.1039/d1fo03804d

Cited by 20 publications

(35 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The corticosterone concentration of rats in the CUMS model increased significantly ( Figure 3C ); the adrenal index also significantly increased ( Figure 3D ). These results were consistent with previous studies, indicating that the CUMS procedure successfully induced depression ( Rubin et al, 1996 ; Herzog et al, 2009 ; Chakraborty et al, 2020 ; Gu et al, 2020 ; Stoneham et al, 2021 ; Xu et al, 2022 ). At the end of 12 weeks, we investigated the serotonin level in plasma samples and observed the trend of a decreased concentration of 5-HT in the CUMS rats.…”

Section: Resultssupporting

confidence: 93%

“…We ignored the effects of behavioral testing on the gut microbiota. The behavioral tests (OFT and SPT) in rats are also a potent psychophysiological stressor that may alter endocrine, neurochemical, immune function, and microbiota, but very little research has been done in this field ( Pawlak et al, 2005 ; Gu et al, 2020 ; Xu et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antidepressant Shugan Jieyu Capsule Alters Gut Microbiota and Intestinal Microbiome Function in Rats With Chronic Unpredictable Mild Stress -Induced Depression

Tan

Zhu

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Shugan Jieyu Capsule (SG) has been widely used in China to treat mild to moderate depression. Hypericum perforatum L. (St John’s Wort, SJW) is the main ingredient of SG and has been used as herbal medicine to treat depression in western countries. However, it is known that SJW has low bioavailability and does not easily get through the blood-brain barrier. Therefore, how SG plays an antidepressant effect in the central nervous system (CNS) remains an urgent problem to be solved. Mounting research has described the relationship between antidepressants and intestinal microbiota to illuminate antidepressive mechanisms in the CNS. We aimed to investigate the effects of therapy with SG on the function of gut microbiota and intestinal microbiota in rats with chronic unpredictable mild stress (CUMS)-induced depression. The psychophysiological state and the hypothalamic-pituitary-adrenal axis function of rats are evaluated through behavioral experiments, corticosterone levels, serotonin levels, and adrenal index measurements. 16S rDNA amplicon sequencing is used to test the changes in gut microbiota and make functional predictions of genes. With treatment of SG, the depression-like behaviors of CUMS-induced rats were reversed; the corticosterone levels and the adrenal index decreased significantly; the level of serotonin increased significantly; and the alpha and beta diversity analysis of microbiota showed an increase in the richness and uniformity of the flora were increased. SG regulated the relative abundance of Actinobacteria, Erysipelotrichaceae, Bifidobacteriaceae, Atopobiaceae, Dubosiella, and Bifidobacterium; Linear discriminant analysis effect size analysis demonstrated that Lactobacillaceae (family level), Lactobacillus (genus level), Lactobacillales (order level), Bacilli (class level), and Lactobacillus-reuteri (species level) were biomarkers in the SG group samples, and also likely to modulate metabolic pathways, such as those involved in carbohydrate metabolism, amino acid metabolism, and signal transduction. These data clearly illustrated the effect of SG on gut microbiome, thus laying the foundation for uncovering more insights on the therapeutic function of the traditional Chinese antidepressants. The potential of SG on mechanisms of antidepression to alter gut microbiota and intestinal microbiome function exposed to CUMS can be explored.

show abstract

Section: Resultssupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Antidepressant Shugan Jieyu Capsule Alters Gut Microbiota and Intestinal Microbiome Function in Rats With Chronic Unpredictable Mild Stress -Induced Depression

Tan

Zhu

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…At the genus level, the abnormal relative abundance of Lachnospiraceae , Turicibacter , Lactobacillus , Bifidobacterium , Streptococcus , Alistipes , Bacteroides , Prevotella , and Akkermansia in individuals with depression or treated for chronic stress reported in a previous study also appeared in this study [ 8 ]. However, elevation of the [Eubacterium] xylanophilum group and Faecalibacterium , reported to be butyrate-producing bacteria, in UCMS-exposed mice contradicted the findings of other studies [ 6 , 39 ]. We did not observe an increase in butyrate levels, suggesting little to no positive effects on depression by the two genera.…”

Section: Discussionmentioning

confidence: 60%

Indole Acetic Acid Exerts Anti-Depressive Effects on an Animal Model of Chronic Mild Stress

et al. 2022

View full text Add to dashboard Cite

Indole acetic acid (IAA), an intestinal bacteria-derived tryptophan metabolite, has been detected at abnormal concentrations in the cerebrospinal fluid and urine of depressed individuals. The effects of such altered IAA concentrations on mood regulation are not known. A mouse model of unpredictable chronic mild stress (UCMS) was used to assess the effects of IAA administration (50 mg/kg). Treatment with IAA for 5 weeks attenuated depression and anxiety-like behaviours, improved hypothalamus–pituitary–adrenal axis dysfunction and increased brain-derived neurotrophic factor expression. IAA supplementation also enhanced the serotonin pathway in the brain and gut. UCMS caused an imbalance of microbial indole metabolites in the colon, whereas IAA treatment reversed this. However, IAA intake did not affect the concentrations of indoles in the brain. Intestinal bacteria in different sections of the gut were altered by IAA treatment, with the colon showing more changes than other segments. The gut microbiome in the colon had increased proportions of Ruminococcaceae UCG013, Ruminiclostridium 6, Prevotella, Alloprevotella and Bacteroides species, which can produce short-chain fatty acids and indole derivatives. Cumulatively, our study highlights the potential of IAA treatment to alleviate mood disorders and offers a theoretical basis for understanding the antidepressant effects of IAA.

show abstract

“…L. rhamnosus restored intestinal damage and improved intestinal inflammation in depressed mice. In summary, this study established that L. rhamnosus was effective in preventing depression due to chronic stress, adding new evidence to support the mental benefits of probiotics [ 180 ].…”

Section: Resultsmentioning

confidence: 99%

Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis

Liaqat

Parveen

Kim

2022

IJMS

View full text Add to dashboard Cite

Modern neurological approaches enable detailed studies on the pathophysiology and treatment of depression. An imbalance in the microbiota–gut–brain axis contributes to the pathogenesis of depression. This extensive review aimed to elucidate the antidepressive effects of brain-derived neurotrophic factor (BDNF)-targeting therapeutic natural products and their derivatives on the gut–brain axis. This information could facilitate the development of novel antidepressant drugs. BDNF is crucial for neuronal genesis, growth, differentiation, survival, plasticity, and synaptic transmission. Signaling via BDNF and its receptor tropomyosin receptor kinase B (TrkB) plays a vital role in the etiopathogenesis of depression and the therapeutic mechanism of antidepressants. This comprehensive review provides information to researchers and scientists for the identification of novel therapeutic approaches for neuropsychiatric disorders, especially depression and stress. Future research should aim to determine the possible causative role of BDNF-TrkB in the gut–brain axis in depression, which will require further animal and clinical research as well as the development of analytical approaches.

show abstract

Lactobacillus rhamnosus zz-1 exerts preventive effects on chronic unpredictable mild stress-induced depression in mice via regulating the intestinal microenvironment

Abstract: Depression remains one of the most prevalent psychiatric disorders, and it has been confirmed that it is related to dysfunction of the microbiota-gut-brain axis. Manipulation of gut microenvironment by probiotics...

Cited by 20 publications

References 55 publications

Antidepressant Shugan Jieyu Capsule Alters Gut Microbiota and Intestinal Microbiome Function in Rats With Chronic Unpredictable Mild Stress -Induced Depression

Antidepressant Shugan Jieyu Capsule Alters Gut Microbiota and Intestinal Microbiome Function in Rats With Chronic Unpredictable Mild Stress -Induced Depression

Indole Acetic Acid Exerts Anti-Depressive Effects on an Animal Model of Chronic Mild Stress

Antidepressive Effect of Natural Products and Their Derivatives Targeting BDNF-TrkB in Gut–Brain Axis

Contact Info

Product

Resources

About