<i>Lacazia loboi</i>
            gen. nov., comb. nov., the Etiologic Agent of Lobomycosis

Taborda, Paulo R.; Taborda, Valeria A.; McGinnis, Michael R.

doi:10.1128/jcm.38.5.2026-2026.2000

Cited by 7 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…The agent of lobomycosis is Lacazia loboi, an intracellular spherical yeast of 8-12 nm of diameter that resides in macrophage vacuoles [4]. The fungus is easily found in lobomycotic skin lesions but it has never been cultivated [4]. The precise natural reservoir of L. loboi is unknown, but soil and vegetation seem to be probable sources of infection [1][2][3].…”

Section: Discussionmentioning

confidence: 99%

“…The direct inoculation into the dermis is probably the way of transmission [4]. The incubation period is long and the infection often goes through a quiescent period (months to years) [3].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Nodules on the right ear

Talhari¹,

Brunasso

Talhari³

et al. 2012

Dermatol Pract Concept

View full text Add to dashboard Cite

A healthy 17-year-old boy with a one-year history of asymptomatic, slowly enlarging nodules affecting his right ear was seen. The patient's past medical history was unremarkable, he was not immunosuppressed, he was not taking any drugs, and he was employed as a rubber worker in the Amazon region. Physical examination revealed ill-defined, smooth, shiny, hard nodules on his right ear (Figure 1). The consistency of the skin lesions was hard, and pain was absent.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Nodules on the right ear

Talhari¹,

Brunasso

Talhari³

et al. 2012

Dermatol Pract Concept

View full text Add to dashboard Cite

show abstract

“…The disease, also known as lobomycosis or lacaziosis, is a chronic, granulomatous, cutaneous-subcutaneous, fungal infection caused by the fungus Lacazia loboi and characterized by isolated or multiple coalescing lesions. These lesions usually show a keloidal aspect and are located primarily on the auricular pavilion and limbs of patients [ 3 , 4 ]. Since it is not compulsory that cases of Jorge Lobo’s disease be reported, the actual number of patients is unknown; however, this affliction is endemic in the Brazilian Amazon region and has presented fewer cases in other countries [ 2 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

DNA damage in BALB/c mice infected with Lacazia loboi and its relation to nutritional status

Barbosa

Oliveira

Tavares

et al. 2015

J Venom Anim Toxins Incl Trop Dis

View full text Add to dashboard Cite

BackgroundJorge Lobo’s disease, also known as lacaziosis, is a cutaneous-subcutaneous mycosis with chronic evolution. It is caused by the fungus Lacazia loboi. Herein we report a study that relates the genotoxicity caused by L. loboi in isogenic mice with nutritional status, through a normal or restricted diet.MethodsDNA damage was assessed in the peripheral blood by the comet assay (tail intensity).ResultsThe results for leukocytes showed increases in the mean tail intensity in mice under dietary restriction, in infected mice under dietary restriction and in infected mice ingesting a normal diet.ConclusionThese results indicate that dietary restriction and L. loboi infection may increase DNA damage levels in mice, as detected by the comet assay.

show abstract

“…A biopsy revealed a chronic granulomatous process ( Figure 1C , arrows) affecting the dermis, with rounded fungi with a thick double wall, forming single chains ( Figure 1C – F , asterisk), and fulfilling the morphologic diagnostic criteria of Lacazia loboi . 1 Lobomycosis is endemic in the Amazon region and is suspected when long-lasting dermal, keloid-like lesions are present in patients from the rainforest or farmers, and diagnosis is based on the biopsy findings. Differential diagnosis includes lepromatous and reactional tuberculoid leprosy, verrucous cutaneous leishmaniasis, chromomycosis, sporotrichosis, and keloids.…”

mentioning

confidence: 99%