<i>Kundmannia sicula</i> (L.) DC: a rich source of germacrene D

Casiglia, Simona; Bruno, Maurizio; Bramucci, Massimo; Quassinti, Luana; Lupidi, Giulio; Fiorini, Dennis; Maggi, Filippo

doi:10.1080/10412905.2017.1338625

Cited by 61 publications

(41 citation statements)

References 24 publications

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“…The major compounds were germacrene-D and trans-caryophyllene, which were found to exert different biological activities in a literature review (Fig. 1): for example, germacrene-D was reported to induce antibacterial [34,35], antioxidant [36], and anticancer activities [36][37][38]; trans-caryophyllene was shown to exhibit anti-inflammatory [39] and antibacterial activities [40,41]. Table 3 Antimicrobial activity of A. squamosa extracts.…”

Section: Discussionmentioning

confidence: 99%

GC-MS profiling and assessment of antioxidant, antibacterial, and anticancer properties of extracts of Annona squamosa L. leaves

Al-Nemari

Al-Senaidy

Semlali

et al. 2020

BMC Complement Med Ther

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Background The research and application of plants in food supplements and drugs have attracted great interest. This study aimed to examine the efficiency of several solvents for the extraction of the main compounds from Annona squamosa leaves and to evaluate the antioxidant, antibacterial, and anticancer activities of these extracts. Methods Gas chromatography-mass spectrometry was used to screen the bioactive compounds of A. squamosa methanolic extract. The free radical, hydrogen peroxide, and nitric oxide scavenging activities of the extracts were investigated. Furthermore, MTT, nuclear staining, LDH, and monolayer wound repair assays were performed to evaluate the potential anticancer activity of the extracts in colon cancer cells while the antibacterial activity was tested by using a well diffusion assay. Results A. squamosa leaves extracts were found to contain several bioactive compounds, of which the majority were sesquiterpenes (C15H24). These extracts exhibited strong antioxidant activity and antibacterial potency against both gram-positive and gram-negative bacteria. Different A. squamosa leaves extracts displayed remarkable antiproliferative, cytotoxic, antimigration, and apoptotic activities in colon cancer cells. Conclusions A. squamosa leaves contain major bioactive compounds that inhibit the growth of several types of bacteria and colon cancer cell lines, which demonstrated their efficacy as an alternative source of antibiotics and for the development of novel drugs for colon cancer therapy.

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Section: Discussionmentioning

confidence: 99%

GC-MS profiling and assessment of antioxidant, antibacterial, and anticancer properties of extracts of Annona squamosa L. leaves

Al-Nemari

Al-Senaidy

Semlali

et al. 2020

BMC Complement Med Ther

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“…It belongs to the sesquiterpenes family, and it has three double links in its structure. There are five types of germacrenes: A, B, C, D, E. Recent studies mention its antioxidant potential [5,54].…”

Section: Sesquiterpenes With Therapeutic Importancementioning

confidence: 99%

Terpenes in Essential Oils: Bioactivity and Applications

Noriega¹

2021

Biochemistry

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Secondary metabolites from plant organisms have always been excellent options for the pharmaceutical, cosmetic, and food industries. Essential oils are a type of metabolites found in vegetables, and their chemical composition is diverse; however, monoterpenes and sesquiterpenes are inside the most abundant molecules. These terpenes have a diverse chemical composition that range from a simple molecule with carbon and hydrogen to more complex molecules with oxygenated organic groups, such as alcohols, aldehydes, ketones, and ethers. Many of these molecules with 10 and 15 carbon atoms have an especially important biological activity, being important the antimicrobial, antifungal, antioxidant, anti-inflammatory, insecticide, analgesic, anticancer, cytotoxic, among others. Some of these substances are potentially toxic, and hence, they should be handled with caution, especially when they are pure. They are easily obtained by different methods, and their industrial value grows every year, with a market of several million dollars. This chapter seeks to provide a better understanding of this type of bioactive molecules, with an emphasis in those whose information is remarkable in the scientific literature and whose value for health and human well-being makes them extremely important.

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“…Fuss ), carrot ( Daucus carota L.), carvi ( Carum carvi L.), and cumin ( Cuminum cyminum L.) . In addition, Apiaceae have also been used as important traditional remedies in the treatment of several ailments . The secondary metabolites of Apiaceae are stored in peculiar secretory structures named ducts and vittae, which are localized in all parts during the plant development .…”

Section: Introductionmentioning

confidence: 99%

Larvicidal Activity of Essential Oils of Five Apiaceae Taxa and Some of Their Main Constituents Against Culex quinquefasciatus

Pavela

Maggi

Cianfaglione

et al. 2017

Chemistry & Biodiversity

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Apiaceae are aromatic herbs producing essential oils which are used on an industrial scale for various purposes. Notably, Apiaceae essential oils may replace synthetic insecticides keeping most of their efficacy and avoiding environmental pollution and human poisoning. In the present work, we explored the insecticidal potential of the essential oils from five Apiaceae taxa, namely Sison amomum, Echinophora spinosa, Heracleum sphondylium subsp. sphondylium, Heracleum sphondylium subsp. ternatum, and Trachyspemum ammi, as well as their major constituents (sabinene, p-cymene, terpinolene, myristicin, and thymol), against the filariasis vector Culex quinquefasciatus. For the purpose, the essential oils were obtained by hydrodistillation and their composition was achieved by gas chromatography/mass spectrometry (GC/MS). Their acute toxicity on third instar larvae of C. quinquefasciatus was determined. The two most active essential oils were those from T. ammi fruits and E. spinosa roots, showing LC 50 below 20 ll/l and LD 90 below 50 ll/l. These oils were dominated by the monoterpene phenol thymol and the phenylpropanoid myristicin, respectively, which showed the strongest larvicidal activity (LC 50 of 15.1 and 16.3 ll/l, respectively) among the pure compounds tested. These results showed that Apiaceae may be useful as source of larvicidal compounds to be used for the development of cheap, effective and eco-friendly insecticidal formulations.

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Kundmannia sicula (L.) DC: a rich source of germacrene D

Cited by 61 publications

References 24 publications

GC-MS profiling and assessment of antioxidant, antibacterial, and anticancer properties of extracts of Annona squamosa L. leaves

GC-MS profiling and assessment of antioxidant, antibacterial, and anticancer properties of extracts of Annona squamosa L. leaves

Terpenes in Essential Oils: Bioactivity and Applications

Larvicidal Activity of Essential Oils of Five Apiaceae Taxa and Some of Their Main Constituents Against Culex quinquefasciatus

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