<i>KRT81</i>Knockdown Inhibits Malignant Progression of Melanoma Through Regulating Interleukin-8

Zhang, Kun; Liang, Yan; Zhang, Wancong; Zeng, Ning; Tang, Shijie; Tian, Ruoxi

doi:10.1089/dna.2021.0317

Cited by 16 publications

(17 citation statements)

References 25 publications

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“…It has been reported that KRT81 plays a predominant role in cancer progression by activating genes related to tumor invasion and migration, such as matrix metallopeptidase 9 and lipocalin 2 [ 26 ]. KRT81 may also function as a regulator of inflammatory cytokine interleukin‐8 and be involved in malignant transformation in melanoma [ 27 ]. The transcription factor HNF1A was originally identified as an important factor in the regulation of glucose metabolism and plays a role in the development of diabetes [ 28 , 29 , 30 ], and also in B‐cell differentiation [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

KRT81 and HNF1A expression in pancreatic ductal adenocarcinoma: investigation of predictive and prognostic value of immunohistochemistry‐based subtyping

Rao,

Sinn,

Pelzer

et al. 2024

The Journal of Pathology CR

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Even after decades of research, pancreatic ductal adenocarcinoma (PDAC) remains a highly lethal disease and responses to conventional treatments remain mostly poor. Subclassification of PDAC into distinct biological subtypes has been proposed by various groups to further improve patient outcome and reduce unnecessary side effects. Recently, an immunohistochemistry (IHC)‐based subtyping method using cytokeratin‐81 (KRT81) and hepatocyte nuclear factor 1A (HNF1A) could recapitulate some of the previously established molecular subtyping methods, while providing significant prognostic and, to a limited degree, also predictive information. We refined the KRT81/HNF1A subtyping method to classify PDAC into three distinct biological subtypes. The prognostic value of the IHC‐based method was investigated in two primary resected cohorts, which include 269 and 286 patients, respectively. In the second cohort, we also assessed the predictive effect for response to erlotinib + gemcitabine. In both PDAC cohorts, the new HNF1A‐positive subtype was associated with the best survival, the KRT81‐positive subtype with the worst, and the double‐negative with an intermediate survival (p < 0.001 and p < 0.001, respectively) in univariate and multivariate analyses. In the second cohort (CONKO‐005), the IHC‐based subtype was additionally found to have a potential predictive value for the erlotinib‐based treatment effect. The revised IHC‐based subtyping using KRT81 and HNF1A has prognostic significance for PDAC patients and may be of value in predicting treatment response to specific therapeutic agents.

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Section: Discussionmentioning

confidence: 99%

KRT81 and HNF1A expression in pancreatic ductal adenocarcinoma: investigation of predictive and prognostic value of immunohistochemistry‐based subtyping

Rao,

Sinn,

Pelzer

et al. 2024

The Journal of Pathology CR

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“…Noteworthily, it was reported that the alteration of DNA damage repair mechanisms through overexpression of midkine (MDK) mediated by p53 in GBM promotes M2 polarization of microglia . Keratin type II cuticular Hb1 is highly expressed in many types of human cancers and is also involved in carcinogenesis . Although the role of keratin remains unclear in the CNS or neurodegenerative diseases, a study highlighted that HMC3 cells passively secrete KRT1, KRT5, and KRT9, while this secretion is not affected by TNF-α-induced inflammation .…”

Section: Discussionmentioning

confidence: 99%

“…63 Keratin type II cuticular Hb1 is highly expressed in many types of human cancers and is also involved in carcinogenesis. 64 Although the role of keratin remains unclear in the CNS or neurodegenerative diseases, a study highlighted that HMC3 cells passively secrete KRT1, KRT5, and KRT9, while this secretion is not affected by TNF-α-induced inflammation. 65 However, further studies will be necessary to fully understand the impact of the KRT81 protein in microglia activation.…”

Section: Discussionmentioning

confidence: 99%

Microglia Polarization and Antiglioma Effects Fostered by Dual Cell Membrane-Coated Doxorubicin-Loaded Hexagonal Boron Nitride Nanoflakes

Şen,

Emanet,

Mazzuferi

et al. 2023

ACS Appl. Mater. Interfaces

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“…Keratin, one of the main components of HNP, might be involved in the regulation of tumor microenvironment. Hair keratin protein–KRT81, can downregulate inflammatory cytokine interleukin-8 to inhibit tumor progression [ 35 ]. Combination immunotherapy for cancer treatment is increasingly showing its superiority [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

Cell membrane-coated human hair nanoparticles for precise disease therapies

Zhang

Xia

et al. 2022

J Nanobiotechnol

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Precision medicine is the ultimate goal for current disease therapies, including tumor and infection. The lack of specific targeted drugs for liver cancer and the lack of specific anti-infective drugs in the treatment of diabetic foot ulcer with infection (DFI) are the representative obstacles in those 2 major diseases currently plaguing human beings. Inventing natural biocompatible polymers derived from natural materials is one of the main development directions of current bio-medical materials. Though previous studies have demonstrated the potential application values of human black hair-derived nanoparticles (HNP) in cancer, methicillin-resistant Staphylococcus aureus (MRSA) infection, and thrombosis scenarios treatments, it still has not solved the problem of low local therapeutic concentration and general targeting ability. Here, we firstly modified the HNP with membrane encapsulations, which endowed these dual-pure natural bio-fabricated materials with better targeting ability at the disease sites with no reduction in photothermal therapy (PTT) effect. HNP coated by red blood cell membrane loaded with DSPE-PEG-cRGD peptide for the therapeutic application of liver cancer greatly prolonged in vivo circulation time and enhanced local targeting efficacy as well as low toxicity; HNP coated by the murine macrophage cell membrane (RAWM) for the DFIs treatment greatly promoted the adhesive ability of HNP on the bacteria and thereby improved the killing effect. Briefly, the appropriate cell membranes camouflaged HNP nanomedicine has the characteristics of excellent photothermal effect, an all-natural source with excellent biocompatibility and easy access, which is expected to have huge potential in both benign and malignant diseases.

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KRT81Knockdown Inhibits Malignant Progression of Melanoma Through Regulating Interleukin-8

Cited by 16 publications

References 25 publications

KRT81 and HNF1A expression in pancreatic ductal adenocarcinoma: investigation of predictive and prognostic value of immunohistochemistry‐based subtyping

KRT81 and HNF1A expression in pancreatic ductal adenocarcinoma: investigation of predictive and prognostic value of immunohistochemistry‐based subtyping

Microglia Polarization and Antiglioma Effects Fostered by Dual Cell Membrane-Coated Doxorubicin-Loaded Hexagonal Boron Nitride Nanoflakes

Cell membrane-coated human hair nanoparticles for precise disease therapies

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