Cell membrane-coated human hair nanoparticles for precise disease therapies

Abstract

Precision medicine is the ultimate goal for current disease therapies, including tumor and infection. The lack of specific targeted drugs for liver cancer and the lack of specific anti-infective drugs in the treatment of diabetic foot ulcer with infection (DFI) are the representative obstacles in those 2 major diseases currently plaguing human beings. Inventing natural biocompatible polymers derived from natural materials is one of the main development directions of current bio-medical materials. Though previous studies have demonstrated the potential application values of human black hair-derived nanoparticles (HNP) in cancer, methicillin-resistant Staphylococcus aureus (MRSA) infection, and thrombosis scenarios treatments, it still has not solved the problem of low local therapeutic concentration and general targeting ability. Here, we firstly modified the HNP with membrane encapsulations, which endowed these dual-pure natural bio-fabricated materials with better targeting ability at the disease sites with no reduction in photothermal therapy (PTT) effect. HNP coated by red blood cell membrane loaded with DSPE-PEG-cRGD peptide for the therapeutic application of liver cancer greatly prolonged in vivo circulation time and enhanced local targeting efficacy as well as low toxicity; HNP coated by the murine macrophage cell membrane (RAWM) for the DFIs treatment greatly promoted the adhesive ability of HNP on the bacteria and thereby improved the killing effect. Briefly, the appropriate cell membranes camouflaged HNP nanomedicine has the characteristics of excellent photothermal effect, an all-natural source with excellent biocompatibility and easy access, which is expected to have huge potential in both benign and malignant diseases.

Injectable Dynamic ROS-Responsive COF-Modified Microalgae Gels for In Vivo bFGF Delivery to Treat Diabetic Wounds

“…Nanotechnology offers the advantage of drug delivery and controlled release, which can effectively address the challenge of drug release. 44 More attractively, beyond serving as drug carriers, many nanomaterials exhibit therapeutic properties for treating diabetic wounds, directly contributing to disease management. 5 Some nanomaterials possess antioxidant, proangiogenic, and antimicrobial effects, which can promote wound healing by regulating the microenvironment, controlling infection, and improving angiogenesis and epithelial regeneration.…”

“…Nanotechnology offers the advantage of drug delivery and controlled release, which can effectively address the challenge of drug release . More attractively, beyond serving as drug carriers, many nanomaterials exhibit therapeutic properties for treating diabetic wounds, directly contributing to disease management .…”

Cell Membrane-Coated Biomimetic Nanoparticles in Cancer Treatment

“…RBCm@NPs Melanoma [30,31] Cervical cancer [32,33] Breast cancer [34,35] Colon cancer [23] Liver cancer [36,37] PLTm@NPs Melanoma [38,39] Table 1. Cont.…”

“…Melanin, known for its excellent PTT properties, has been identified as a potent agent [ 101 ]. Zhang et al [ 36 ] extracted melanin NPs (HNPs) from human black hair for liver cancer PTT. Modified with the cRGD peptide via the lipid insertion approach, RBCm was coated onto HNPs (HNP@RBCm-cRGD) to enhance their circulation time and achieve a greater accumulation efficiency, without compromising the PTT conversion capability of HNP.…”

Cell Membrane Biomimetic Nano-Delivery Systems for Cancer Therapy

“…The immune escape ability of cancer cells is mediated by overexpression of CD47 on the cell membrane. Moreover, cancer-homing properties are associated with cancer cell membrane surface adhesion molecules (CCAM), such as selectins, calreticulin, integrins, immunoglobulin superfamily (Ig-SF), and lymphocyte homing receptors [ 127 , 128 , 129 , 130 , 131 ]. These cancer cell capabilities can be inherited by CCNDS.…”