<i>Interleukin 10</i>gene rs1800896 polymorphism is associated with the risk of prostate cancer

Chen, Hao; Tang, Jilei; Shen, Nan

doi:10.18632/oncotarget.19857

Cited by 11 publications

(8 citation statements)

References 38 publications

(66 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Discussionmentioning

confidence: 99%

“…A previous study suggested that the secretion of IL-10 is determined largely (74%) by heritable factors 23 . Several studies have found an association between the IL-10 -1082 G/A polymorphism and oral cancer,head and neck cancer 24 , 25 . Because meta-analysis is a suitable method to evaluate small effects in genetic association studies, we designed this study to systematically evaluate the association of the IL-10 -1082 G/A polymorphism with HCC risk.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Association between the Interleukin-10 -1082 G/A polymorphism and risk of hepatocellular carcinoma

Wang¹,

Hu²

2020

Afr H. Sci.

View full text Add to dashboard Cite

Background: Inconsistent results have been reported from studies investigating the relationship of the interleukin-10 (IL-10) -1082 G/A polymorphism and the susceptibility of hepatocellular carcinoma (HCC). Therefore, a thorough literature review of relatedstudies was performed in this meta-analysis to examine the association of the interleukin-10(IL-10) -1082 G/A poly- morphism with HCC susceptibility. Methods: Electronic databases were searched for literature on the relationship between interleukin-10(IL-10) -1082 G/A poly- morphism and the risk of HCC in accordance with the inclusion and exclusion criteria. The selected studies were analyzed using the Stata 12.0 software. Finally, the strength of the associations was evaluated using the odds ratio (OR) and 95% confidence intervals (95% CI). Results: A total of six case-control studies were enrolled into the current meta-analysis, which included a total of 911 patients and 1889 control subjects. Our data revealed no association between the IL-10 -1082 G/A polymorphism and the risk of HCC (GG vs AA:OR=0.84, 95%CI=0.57-1.25; AG vs AA:OR=0.85, 95%CI=0.70-1.05; Dominant model: OR=0.85, 95%CI=0.70- 1.03; and Recessive model: OR=0.92, 95%CI = 0.64-1.32). Similarly, no association was found in sub-group analysis based on ethnicity. Conclusion: The results of our study suggest no association between IL-10 -1082 G/A polymorphism and the risk of HCC. Keywords: Hepatocellular carcinoma; IL-10 polymorphism; risk analysis.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between the Interleukin-10 -1082 G/A polymorphism and risk of hepatocellular carcinoma

Wang¹,

Hu²

2020

Afr H. Sci.

View full text Add to dashboard Cite

show abstract

“…A study looking for the participation of variant alleles at both −819 and −592 polymorphisms was modestly associated with the advanced stages of prostate cancer [82,83]. Other meta-analysis reports that rs1800896 polymorphism is associated with a decreased risk of prostate cancer [84].…”

Section: Diseasementioning

confidence: 99%

IL10 as Cancer Biomarker

González‐Garza¹,

Cruz-Vega²,

Maldonado‐Bernal³

2021

Translational Research in Cancer

View full text Add to dashboard Cite

Chronic inflammation can trigger events that would induce the malignant transformation of cells and carcinogenesis. Cytokines play a crucial role and can control the development and multiplication of cancerous cells. However, clinical data present controversy about the participation of these proteins in the establishment and development of cancer. Interleukin 10 (IL-10), a potent anti-inflammatory cytokine, has been the subject of multiple studies. Several studies have reported that IL-10 has pro-and antitumor effects. Elevated levels of IL-10 are associated with increased tumor growth with poor prognosis and drug resistance. However, this cytokine has both tumor-promoting and tumor-inhibiting properties. In vitro and in vivo studies report mechanisms by which IL-10 expression downregulates class I, which results in the control of the metastatic disease. IL-10 also inhibits tumorigenesis via downregulation of other cytokines. The variation observed could be the result of concentration ranges of this protein, genetic polymorphism, or both. The value obtained may serve as a biomarker indicative of tumor development and its prognosis.

show abstract

“…SNPs in the transcriptional start area of IL-10 gene influence the production of IL-10 thus may increase or decrease the risk of cancers, [ 10 – 12 ] including leukemia, but the conclusions are inconsistent. For example, Ovsepyan, V. A. et al [ 13 ] found SNP in the IL-10 -1082A/G was associated with the risk of chronic lymphoid leukemia, while Lo, W. J. et al [ 14 ] found no association between IL-10 -1082A/G and leukemia.…”

Section: Introductionmentioning

confidence: 99%

The single nucleotide polymorphisms of interleukin-10 are associated with the risk of leukaemia

et al. 2020

View full text Add to dashboard Cite

Interleukin-10(IL-10) is an immunosuppressive cytokine and plays an important role in inflammation and cancers. Numerous studies have explored the association between single nucleotide polymorphisms of IL-10 and leukemia, but their results were conflicting, so we performed this meta-analysis to elucidate the association between 3 common single nucleotide polymorphisms of IL-10 (rs1800896, rs1800871 and rs1800872) and risk of leukemia. We conducted a comprehensive research in Pubmed, Chinese Biomedical Literature Database disc and Embase using related terms. After strict selection, 18 studies with 2264 cases and 3846 controls were included into this meta-analysis. Odds ratio and 95% confidence interval were used to evaluate the strength of the association. We found that polymorphism of IL-10 -1082A/G was associated with decreased risk of leukemia both in overall analysis and in stratified analysis according to ethnicity and cancer type. A strong relationship was also uncovered between polymorphism of IL-10 -592C/A and increased risk of leukemia in non-Chinese. GG genotype of IL-10 -1082A/G is associated with decreased risk of leukemia, especially chronic lymphocytic leukemia. CC genotype of -592C/A is associated with decreased risk of leukemia in non-Chinese.

show abstract

Interleukin 10gene rs1800896 polymorphism is associated with the risk of prostate cancer

Cited by 11 publications

References 38 publications

Association between the Interleukin-10 -1082 G/A polymorphism and risk of hepatocellular carcinoma

Association between the Interleukin-10 -1082 G/A polymorphism and risk of hepatocellular carcinoma

IL10 as Cancer Biomarker

The single nucleotide polymorphisms of interleukin-10 are associated with the risk of leukaemia

Contact Info

Product

Resources

About