<i>In vivo</i> validation of spray-dried mesoporous bioactive glass microspheres acting as prolonged local release systems for BMP-2 to induce bone regeneration

Berkmann, Julia C.; Martin, Aaron X. Herrera; Pontremoli, Carlotta; Zheng, Kai; Bucher, Christian H.; Ellinghaus, Agnes; Boccaccını, Aldo R.; Fiorilli, Sonia Lucia; Vitale-Brovarone, C.; Duda, Georg N.; Schmidt‐Bleek, Katharina

doi:10.1101/2020.03.21.001404

Cited by 5 publications

(1 citation statement)

References 66 publications

(14 reference statements)

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“…Such mesopores allow biomolecules with different biological activities to be included in the scaffolds [ 96 ]. Particularly, signal molecules can be included for RM of bone regeneration that induce bone formation, such as bone morphogenetic protein (BMP) [ 97 ], growth factors such as vascular endothelial growth factor [ 98 ], or different fractions of parathyroid hormone–related peptide (PTHrP) [ 99 ]. Table 1 collects a number of biomolecules and drugs which loading into MBGs has been investigated.…”

Section: Loading Mesoporous Glasses With Biomolecules and Drugsmentioning

confidence: 99%

Mesoporous bioactive glasses for regenerative medicine

Vallet‐Regí

Salinas

2021

Materials Today Bio

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Stem cells are the central element of regenerative medicine (RM). However, in many clinical applications, the use of scaffolds fabricated with biomaterials is required. In this sense, mesoporous bioactive glasses (MBGs) are going to play an important role in bone regeneration because of their striking textural properties, quick bioactive response, and biocompatibility. As other bioactive glasses, MBGs are mainly formed by silicon, calcium, and phosphorus oxides whose ions play an important role in cell proliferation as well as in homeostasis and bone remodeling process. A common improvement of bioactive glasses for RM is by adding small amounts of oxides of elements that confer them additional biological capacities, including osteogenic, angiogenic, antibacterial, anti-inflammatory, hemostatic, or anticancer properties. Moreover, MBGs are versatile in terms of the different ways in which they can be processed, such as scaffolds, fibers, coatings, or nanoparticles. MBGs are unique because their textural properties are so high that they still exhibit outstanding bioactive responses even after adding extra inorganic ions or being processed as scaffolds or nanoparticles. Moreover, they can be further improved by loading with biomolecules, drugs, and stem cells. This article reviews the state of the art and future perspectives of MBGs in the field of RM of hard tissues.

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Section: Loading Mesoporous Glasses With Biomolecules and Drugsmentioning

confidence: 99%

Mesoporous bioactive glasses for regenerative medicine

Vallet‐Regí

Salinas

2021

Materials Today Bio

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Optimization of an Injectable, Resorbable, Bioactive Cement Able to Release the Anti-Osteoclastogenic Biomolecule ICOS-Fc for the Treatment of Osteoporotic Vertebral Compression Fractures

et al. 2023

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Vertebral compression fractures are typical of osteoporosis and their treatment can require the injection of a cement through a minimally invasive procedure to restore vertebral body height. This study reports the development of an injectable calcium sulphate-based composite cement able to stimulate bone regeneration while inhibiting osteoclast bone resorption. To this aim, different types of strontium-containing mesoporous glass particles (Sr-MBG) were added to calcium sulphate powder to impart a pro-osteogenic effect, and the influence of their size and textural features on the cement properties was investigated. Anti-osteoclastogenic properties were conferred by incorporating into poly(lactic-co-glycolic)acid (PLGA) nanoparticles, a recombinant protein able to inhibit osteoclast activity (i.e., ICOS-Fc). Radiopaque zirconia nanoparticles (ZrO2) were also added to the formulation to visualize the cement injection under fluoroscopy. The measured cement setting times were suitable for the clinical practice, and static mechanical testing determined a compressive strength of ca. 8 MPa, comparable to that of human vertebral bodies. In vitro release experiments indicated a sustained release of ICOS-Fc and Sr2+ ions up to 28 days. Overall, the developed cement is promising for the treatment of vertebral compression fractures and has the potential to stimulate bone regeneration while releasing a biomolecule able to limit bone resorption.

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Optimisation of the Flame Spheroidisation Process for the Rapid Manufacture of Fe3O4-Based Porous and Dense Microspheres

et al. 2023

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The rapid, single-stage, flame-spheroidisation process, as applied to varying Fe3O4:CaCO3 powder combinations, provides for the rapid production of a mixture of dense and porous ferromagnetic microspheres with homogeneous composition, high levels of interconnected porosity and microsphere size control. This study describes the production of dense (35–80 µm) and highly porous (125–180 µm) Ca2Fe2O5 ferromagnetic microspheres. Correlated backscattered electron imaging and mineral liberation analysis investigations provide insight into the microsphere formation mechanisms, as a function of Fe3O4/porogen mass ratios and gas flow settings. Optimised conditions for the processing of highly homogeneous Ca2Fe2O5 porous and dense microspheres are identified. Induction heating studies of the materials produced delivered a controlled temperature increase to 43.7 °C, indicating that these flame-spheroidised Ca2Fe2O5 ferromagnetic microspheres could be highly promising candidates for magnetic induced hyperthermia and other biomedical applications.

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In vivo validation of spray-dried mesoporous bioactive glass microspheres acting as prolonged local release systems for BMP-2 to induce bone regeneration

Cited by 5 publications

References 66 publications

Mesoporous bioactive glasses for regenerative medicine

Mesoporous bioactive glasses for regenerative medicine

Optimization of an Injectable, Resorbable, Bioactive Cement Able to Release the Anti-Osteoclastogenic Biomolecule ICOS-Fc for the Treatment of Osteoporotic Vertebral Compression Fractures

Optimisation of the Flame Spheroidisation Process for the Rapid Manufacture of Fe3O4-Based Porous and Dense Microspheres

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