2016
DOI: 10.1111/gtc.12349
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In vivo tracking of histone H3 lysine 9 acetylation in Xenopus laevis during tail regeneration

Abstract: Xenopus laevis tadpoles can completely regenerate their appendages, such as tail and limbs, and therefore provide a unique model to decipher the molecular mechanisms of organ regeneration in vertebrates. Epigenetic modifications are likely to be involved in this remarkable regeneration capacity, but they remain largely unknown. To examine the involvement of histone modification during organ regeneration, we generated transgenic X. laevis ubiquitously expressing a fluorescent modification-specific intracellular… Show more

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Cited by 32 publications
(21 citation statements)
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References 53 publications
(71 reference statements)
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“…It is expected that the establishment of positional information is mediated by epigenetic modification, for example, methylation and acetylation of histones and DNA methylation (Hayashi et al, 2015;Suzuki et al, 2016;Tseng & Levin, 2012;Yakushiji, Yokoyama, & Tamura, 2009). It is expected that the establishment of positional information is mediated by epigenetic modification, for example, methylation and acetylation of histones and DNA methylation (Hayashi et al, 2015;Suzuki et al, 2016;Tseng & Levin, 2012;Yakushiji, Yokoyama, & Tamura, 2009).…”
Section: Epigenetic Regulation Induced By Vitamin a Treatmentmentioning
confidence: 99%
See 2 more Smart Citations
“…It is expected that the establishment of positional information is mediated by epigenetic modification, for example, methylation and acetylation of histones and DNA methylation (Hayashi et al, 2015;Suzuki et al, 2016;Tseng & Levin, 2012;Yakushiji, Yokoyama, & Tamura, 2009). It is expected that the establishment of positional information is mediated by epigenetic modification, for example, methylation and acetylation of histones and DNA methylation (Hayashi et al, 2015;Suzuki et al, 2016;Tseng & Levin, 2012;Yakushiji, Yokoyama, & Tamura, 2009).…”
Section: Epigenetic Regulation Induced By Vitamin a Treatmentmentioning
confidence: 99%
“…Recently, extensive epigenetic analyses of amphibian regeneration have been performed. It is expected that the establishment of positional information is mediated by epigenetic modification, for example, methylation and acetylation of histones and DNA methylation (Hayashi et al, 2015;Suzuki et al, 2016;Tseng & Levin, 2012;Yakushiji, Yokoyama, & Tamura, 2009). However, little is known about the roles of epigenetic regulation during tail regeneration.…”
Section: Epigenetic Regulation Induced By Vitamin a Treatmentmentioning
confidence: 99%
See 1 more Smart Citation
“…Recently, Suzuki and colleagues reported a simple but important improvement in NHEJ-mediated knock-in strategy, referred to as the HITI (homology-independent targeted integration) method (Suzuki et al 2016a). They used a common single-guide RNA (sgRNA) for the cleavage of genomic target site and donor DNA, but the orientation of the sgRNA target site on the donor DNA was flipped.…”
Section: Nhej-mediated Gene Knock-inmentioning
confidence: 99%
“…An increase in H3K9ac was detected as an increase in the ratio of nuclear to cytoplasmic intensity when a histone deacetylase inhibitor was added to hTERT-RPE1 cells expressing H3K9ac-mintbody11. Transgenic animals stably expressing H3K9ac-mintbody have been constructed in fruit fly ( Drosophila melanogaster ), zebrafish ( Danio rerio ) and Xenopus laevis 111213. An increase of H3K9ac could be monitored in specific regions during embryogenesis and organ development of these transgenic animals.…”
mentioning
confidence: 99%