<i>In vivo</i> quantitative imaging of normal and cancerous breast tissue using broadband diffuse optical tomography

Wang, Jia; Jiang, Shudong; Li, Zhongze; diFlorio-Alexander, Roberta; Barth, Richard J.; Kaufman, Peter A.; Pogue, Brian W.; Paulsen, Keith D.

doi:10.1118/1.3455702

Cited by 73 publications

(73 citation statements)

References 39 publications

(52 reference statements)

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“…Abbreviations: BSA, bovine serum albumin; TF, Thomsen-Friedenreich. 17 the nanobeacon is an indispensable component. For instance, with the recent US Food and Drug Administration (FDA) approval of DNA-based CRC detection in the stool, it is clear that the kit might reveal a positive outcome via DNA detection.…”

mentioning

confidence: 99%

Evaluation of a novel fluorescent nanobeacon for targeted imaging of Thomsen-Friedenreich associated colorectal cancer

Nakase

Sakuma

Fukuchi

et al. 2017

IJN

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The Thomsen–Friedenreich (TF) antigen represents a prognostic biomarker of colorectal carcinoma. Here, using a nanobeacon, the surface of which was fabricated with peanut agglutinin as TF-binding molecules, we demonstrate that the nanobeacon is able to detect TF antigen in frozen and freshly biopsied polyps using fluorescence microscopy. Our results provide important clues about how to detect aberrant colonic tissues in the most timely fashion. Given the versatile application method for this topical nanobeacon, the protocol used in this work is amenable to clinical colonoscopy. Moreover, the prospects of clinical translation of this technology are evident.

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confidence: 99%

Evaluation of a novel fluorescent nanobeacon for targeted imaging of Thomsen-Friedenreich associated colorectal cancer

Nakase

Sakuma

Fukuchi

et al. 2017

IJN

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“…Interestingly, soft compression of the breast with nearly uniform force (details not identified) was achieved by deforming a silicone membrane over the upper surface. Unlike results reported here and by the other groups [50,72,73], optical measures were restricted to a single wavelength (640 nm). In general, while evidence of sensitivity to the presence of cancerous tumors was demonstrated along with the suggestion of interesting differences in the dynamics between affected and unaffected regions, it was noted that the optical measure had a high rate of false-positive responses (32%) compared to negative MR controls.…”

Section: Inversion Of Optical Datamentioning

confidence: 96%

“…Naturally, the utility of optical methods is based on the expectation that such changes impact wavelengthdependent absorption or scattering properties of tissue. While evidence has been presented that such changes do yield promising clinical sensitivity and specificity [50,72,73], the fact is that, compared to the structural imaging methods, the optical methods suffer from decidedly low spatial resolution.…”

Section: Inversion Of Optical Datamentioning

confidence: 99%

Optomechanical imaging system for breast cancer detection

Abdi

Graber

et al. 2011

J. Opt. Soc. Am. A

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Imaging studies of the breast comprise three principal sensing domains: structural, mechanical, and functional. Combinations of these domains can yield either additive or wholly new information, depending on whether one domain interacts with the other. In this report, we describe a new approach to breast imaging based on the interaction between controlled applied mechanical force and tissue hemodynamics. Presented is a description of the system design, performance characteristics, and representative clinical findings for a second-generation dynamic near-infrared optical tomographic breast imager that examines both breasts simultaneously, under conditions of rest and controlled mechanical provocation. The expected capabilities and limitations of the developed system are described in relation to the various sensing domains for breast imaging.

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“…A variety of DOT systems have been reported for functional imaging or tumor detection, including in the breast [18][19][20] and brain [21,22]. Of particular relevance here is a system that combined continuous-wave (CW) transrectal diffuse optical tomography (CW-TRDOT) with twodimensional (2-D) TRUS for prostate cancer detection and quantification, based on the tumor having higher optical absorption than normal prostate in the NIR [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Diffuse optical tomography to monitor the photocoagulation front during interstitial photothermal therapy: Numerical simulations and measurements in tissue-simulating phantoms

Wilson

Piao

et al. 2014

Photonics &Amp; Lasers in Medicine

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Near-infrared interstitial photothermal therapy (PTT) is currently undergoing clinical trials as an alternative to watchful waiting or radical treatments in patients with low/intermediate-risk focal prostate cancer. Currently, magnetic resonance imaging (MRI)-based thermography is used to monitor thermal energy delivery and determine indirectly the completeness of the target tumor destruction while avoiding damage to adjacent normal tissues, particularly the rectal wall. As an alternative, transrectal diffuse optical tomography (TRDOT) is being developed to image directly the photocoagulation boundary based on the changes in tissue optical properties, particularly scattering. An established diffusion-theory finite-element software platform was used to perform forward simulations to determine the sensitivity of changes in the optical signal resulting from a growing coagulated lesion with optical scattering contrast, for varying light source-detector separations in both longitudinal and transverse imaging geometries. The simulations were validated experimentally in tissue-simulating phantoms using an existing continuous-wave TRDOT system, in a configuration that is representative of one potential intended clinical use. This provides critical guidance for the optimum design of the transrectal applicator probe, in terms of achieving maximum sensitivity to the presence of the coagulation boundary and, consequently, the highest accuracy in determining the boundary location relative to the rectal wall.Keywords: focal prostate cancer; interstitial photothermal therapy; diffuse optical tomography Zusammenfassung: Die interstitielle photothermische Therapie im Nahinfrarotbereich wird derzeit in klinischen Studien als Alternative zum ‚Watchful Waiting' (beobachtendes Abwarten) bzw. zur radikalen Behandlung von Patienten mit Prostatakrebs der Niedrig-und Mittelrisikogruppe untersucht. Derzeit wird die MR-Thermografie eingesetzt, um die Deposition der thermischen Energie zu überwachen und indirekt die vollständige Tumorzerstö-rung bei gleichzeitiger Vermeidung einer Schädigung des angrenzenden gesunden Gewebes, insbesondere der Rektumwand, zu überprüfen. Als Alternative wurde das Verfahren der transrektalen diffusen optischen Tomographie (TRDOT) entwickelt, mit dem Ziel, die Grenzen der Photokoagulation direkt anhand der Veränderungen in den optischen Gewebeeigenschaften, insbesondere der Streuung, darzustellen. Eine etablierte Software-Plattform auf Basis der Diffusionstheorie und Finite-Elemente-Methode wurde zur Durchführung von Vorwärtssimulationen verwendet, um die Empfindlichkeit der Änderungen des optischen Signals in einer wachsenden Koagulationszone mit optischem Streukontrast zu bestimmen -sowohl für unterschiedliche Lichtquelle/Detektor-Abstände als auch in Längs-und Querausrichtung. Die Simulationen wurden mit einem vorhandenen kontinuierlich abstrahlenden TRDOT-System experimentell in Gewebephantomen validiert -und zwar in einer Konfiguration, die repräsentativ für eine potentielle klinische Anwendung ...

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In vivo quantitative imaging of normal and cancerous breast tissue using broadband diffuse optical tomography

Abstract: In vivo breast imaging with instrumentation that combines FD and CW NIR data acquisition in a single spectral reconstruction produces more accurate hemoglobin, water, and lipid results relative to FD data alone.

Cited by 73 publications

References 39 publications

Evaluation of a novel fluorescent nanobeacon for targeted imaging of Thomsen-Friedenreich associated colorectal cancer

Evaluation of a novel fluorescent nanobeacon for targeted imaging of Thomsen-Friedenreich associated colorectal cancer

Optomechanical imaging system for breast cancer detection

Diffuse optical tomography to monitor the photocoagulation front during interstitial photothermal therapy: Numerical simulations and measurements in tissue-simulating phantoms

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