Optomechanical imaging system for breast cancer detection

Abdi, Rabah Al; Graber, Harry L.; Xu, Yong; Barbour, Randall L.

doi:10.1364/josaa.28.002473

Cited by 39 publications

(31 citation statements)

References 72 publications

(157 reference statements)

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“…These tumor blood vessels tend to be less well formed than those in healthy tissue, with leaky and chaotic networks (84). These differences, in fact, offer clinicians unique contrasts that have been the subject of numerous investigations using diffuse optics (24,30,40,42,43,45,47,48,85,86) and other techniques. Given these differences in tissue composition, it is quite likely that tumor vasculature will respond differently to compression perturbations compared to healthy tissue.…”

Section: Discussionmentioning

confidence: 99%

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Blood Flow Reduction in Breast Tissue due to Mammographic Compression

et al. 2014

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Rationale and objectives This study measures hemodynamic properties such as blood flow and hemoglobin concentration and oxygenation in the healthy human breast under a wide range of compressive loads. Because many breast-imaging technologies derive contrast from the deformed breast, these load-dependent vascular responses affect contrast agent–enhanced and hemoglobin-based breast imaging. Methods Diffuse optical and diffuse correlation spectroscopies were used to measure the concentrations of oxygenated and deoxygenated hemoglobin, lipid, water, and microvascular blood flow during axial breast compression in the parallel-plate transmission geometry. Results Significant reductions (P < .01) in total hemoglobin concentration (~30%), blood oxygenation (~20%), and blood flow (~87%) were observed under applied pressures (forces) of up to 30 kPa (120 N) in 15 subjects. Lipid and water concentrations changed <10%. Conclusions Imaging protocols based on injected contrast agents should account for variation in tissue blood flow due to mammographic compression. Similarly, imaging techniques that depend on endogenous blood contrasts will be affected by breast compression during imaging.

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Section: Discussionmentioning

confidence: 99%

“…In future studies, it would be interesting to use DCS in transmission to probe the tumor-bearing breast and thereby study the differential vasculature-related responses to compressional stresses. Such differential responses might be useful for tumor detection and characterization [see, for example, previous studies (43,47,87)].…”

Section: Discussionmentioning

confidence: 99%

Blood Flow Reduction in Breast Tissue due to Mammographic Compression

et al. 2014

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“…The focus is primarily on CW imaging based on tomographic projection measurements acquired at multiple wavelengths with provisions for adding limited FD recordings optimized to the design. Other breast-imaging approaches with a similar emphasis on CW imaging with solid-state detectors have been developed in the recent years [10,11].…”

Section: Introductionmentioning

confidence: 99%

A digital x-ray tomosynthesis coupled near infrared spectral tomography system for dual-modality breast imaging

Krishnaswamy¹,

Michaelsen²,

Pogue³

et al. 2012

Opt. Express

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A Near Infrared Spectral Tomography (NIRST) system has been developed and integrated into a commercial Digital Breast Tomosynthesis (DBT) scanner to allow structural and functional imaging of breast in vivo. The NIRST instrument uses an 8-wavelength continuous wave (CW) laserbased scanning source assembly and a 75-element silicon photodiode solidstate detector panel to produce dense spectral and spatial projection data from which spectrally constrained 3D tomographic images of tissue chromophores are produced. Integration of the optical imaging system into the DBT scanner allows direct co-registration of the optical and DBT images, while also facilitating the synergistic use of x-ray contrast as anatomical priors in optical image reconstruction. Currently, the total scan time for a combined NIRST-DBT exam is ~50s with data collection from 8 wavelengths in the optical scan requiring ~42s to complete. The system was tested in breast simulating phantoms constructed using intralipid and blood in an agarose matrix with a 3 cm x 2 cm cylindrical inclusion at 1 cm depth from the surface. Diffuse image reconstruction of total hemoglobin (HbT) concentration resulted in accurate recovery of the lateral size and position of the inclusion to within 6% and 8%, respectively. Use of DBT structural priors in the NIRST reconstruction process improved the quantitative accuracy of the HbT recovery, and led to linear changes in imaged versus actual contrast, underscoring the advantages of dual-modality optical imaging approaches. The quantitative accuracy of the system can be further improved with independent measurements of scattering properties through integration of frequency or time domain data. ©2012 Optical Society of America

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“…Both gas inhalation/breath-holding [36,37] and external mechanical stimuli [38][39][40][41][42][43][44][45][46] have been proposed to develop novel imaging biomarkers of breast cancer. In particular, our group has obtained promising initial results by dynamically imaging the breast tissue response to fractional mammographic compression [47,48].Tissue viscoelastic relaxation during the compression period leads to a slow reduction in the compression force and reveals biomechanical and metabolic differences between normal and lesion tissue.…”

Section: Introductionmentioning

confidence: 99%

Normalization of compression-induced hemodynamics in patients responding to neoadjuvant chemotherapy monitored by dynamic tomographic optical breast imaging (DTOBI)

Sajjadi¹,

Isakoff²,

Deng³

et al. 2017

Biomed. Opt. Express

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Abstract:We characterize novel breast cancer imaging biomarkers for monitoring neoadjuvant chemotherapy (NACT) and predicting outcome. Specifically, we recruited 30 patients for a pilot study in which NACT patients were imaged using dynamic tomographic optical breast imaging (DTOBI) to quantify the hemodynamic changes due to partial mammographic compression. DTOBI scans were obtained pre-treatment (referred to as day 0), as well as 7 and 30 days into therapy on female patients undergoing NACT. We present data for the 13 patients who participated in both day 0 and 7 measurements and had evaluable data, of which 7 also returned for day 30 measurements. We acquired optical images over 2 minutes following 4-8 lbs (18-36 N) of compression. The timecourses of tissue-volume averaged total hemoglobin (HbT), as well as hemoglobin oxygen saturation (SO 2 ) in the tumor vs. surrounding tissues were compared. Outcome prediction metrics based on the differential behavior in tumor vs. normal areas for responders (>50% reduction in maximum diameter) vs. non-responders were analyzed for statistical significance. At baseline, all patients exhibit an initial decrease followed by delayed recovery in HbT, and SO 2 in the tumor area, in contrast to almost immediate recovery in surrounding tissue. At day 7 and 30, this contrast is maintained in non-responders; however, in responders, the contrast in hemodynamic time-courses between tumor and normal tissue starts decreasing at day 7 and substantially disappears at day 30. At day 30 into NACT, responding tumors demonstrate "normalization" of compression induced hemodynamics vs. surrounding normal tissue whereas non-responding tumors did not. This data suggests that DTOBI imaging biomarkers, which are governed by the interplay between tissue biomechanics and oxygen metabolism, may be suitable for guiding NACT by offering early predictions of treatment outcome. Yaffe, and G. J. Czarnota, "Evaluation of neoadjuvant chemotherapy response in women with locally advanced breast cancer using ultrasound elastography," Transl. Oncol. 6(1), 17-24 (2013).

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Optomechanical imaging system for breast cancer detection

Cited by 39 publications

References 72 publications

Blood Flow Reduction in Breast Tissue due to Mammographic Compression

Blood Flow Reduction in Breast Tissue due to Mammographic Compression

A digital x-ray tomosynthesis coupled near infrared spectral tomography system for dual-modality breast imaging

Normalization of compression-induced hemodynamics in patients responding to neoadjuvant chemotherapy monitored by dynamic tomographic optical breast imaging (DTOBI)

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