<i>In vivo</i> percutaneous permeation of gold nanomaterials in consumer cosmetics: implication in dermal safety assessment of consumer nanoproducts

Cao, Mingjing; Li, Bai; Guo, Mengyu; Liu, Ying; Zhang, Lili; Wang, Yaling; Hu, Bin; Li, Jiayang; Sutherland, Duncan S.; Wang, Liming; Chen, Chunying

doi:10.1080/17435390.2020.1860264

Cited by 20 publications

(9 citation statements)

References 42 publications

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“…The viability of HaCaT cells exposed to Au NMs or Au NM-Cream at various surface area dosages (equivalent to Au content) was measured by the CCK-8 assay kit (Beyotime, Shanghai, China). Considering that the daily usages of facial cream and face area are 2 g and 600 cm 2 [21,24], respectively, the daily surface area dosage of facial cream was calculated to be 3.33 mg cm −2 . Based on the Au content (1.85 mg kg −1 cream) in facial cream, the daily surface area dosage was 6.1 ng cm −2 .…”

Section: Cell Viability Assessmentmentioning

confidence: 99%

“…Recently, pilot studies have reported to successfully separate Au nanosheets from commercial cosmetics and investigate their toxicity on human keratinocytes and guinea pig skin [20,21]. It was found that cosmetic cream enhanced the cytotoxicity of Au nanosheets in HaCaT keratinocytes, which is ascribed to the toxic ingredients of cosmetic cream.…”

Section: Introductionmentioning

confidence: 99%

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Dermal Toxicity Influence of Gold Nanomaterials after Embedment in Cosmetics

Liu

Wang

Zhang

et al. 2022

Toxics

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Gold nanomaterials (Au NMs) have been widely used in cosmetic products for improving the brightening, and reducing the wrinkling of, skin, etc.; however, the dermal safety of Au NMs is rarely concerned. A previous study found that cosmetics could enhance the toxicity of Au nanosheets, but different physicochemical properties of Au NMs will induce different interaction modes with ingredients of cosmetics, potentially leading to different toxicity profiles. In the present study, spherical and rodlike Au NMs were first found in commercial cosmetics, and then Au nanospheres (NSs) with different sizes and Au nanorods (NRs) with different aspect ratios were prepared to simulate these Au NMs in cosmetics and further investigate their toxicity before and after embedment in cosmetics. It was found that the primary sizes, morphologies, and optical absorptions of these Au NSs and NRs before and after embedment were similar; however, their hydrodynamic sizes and zeta potentials were noticeably different. Then, these Au NSs and NRs presented weak or no cytotoxicity against HaCaT keratinocytes, while cosmetic cream could alleviate their cytotoxicity. Moreover, the cream could enhance the accumulation of Au NSs and NRs in the skin of hairless mice, but it also alleviated the toxicological responses of Au NSs and NRs in terms of superoxide dismutase (SOD) elevation and malondialdehyde (MDA) reduction. Therefore, the embedment of Au NSs and NRs into cosmetics can alleviate the in vitro and in vivo dermal toxicities of Au NSs and NRs.

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Section: Cell Viability Assessmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dermal Toxicity Influence of Gold Nanomaterials after Embedment in Cosmetics

Liu

Wang

Zhang

et al. 2022

Toxics

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“…It has been demonstrated that gold nanoparticles are able to reduce wrinkles [56], improve skin brightening, promote skin healing, have a cleansing effect, reduce inflammation and ROS damage, provide anti-bacterial action, slow down collagen depletion [57] and elastin degradation [58]. Nevertheless, concerns have been expressed about a safe use of gold-based nano-cosmeceuticals, since it has been demonstrated that Au nanosheets in cosmetic creams are able to quantitatively permeate into the skin epidermis, dermis and subcutaneous layer after a ten-day cutaneous exposure [139]. The same study also showed that Au nanosheets are not able to enter the systemic circulation, though, but can decrease the cell viability of keratinocytes and induce a low level of apoptosis or necrosis of keratinocytes and skin dermal fibroblasts.…”

Section: Nanoformulations For Skin Care and Anti-aging Productsmentioning

confidence: 99%

“…Skin has been generally considered as a strong barrier to the penetration of nanoparticles in the body, although different papers recently appeared in the literature showing that this is not always true [139]. Damaged skin, such as in burns and wounds, is more penetrable by NPs as compared to healthy derma, therefore the formulation of wound dressings and nano-cosmetics should be carefully designed and thoroughly tested in the respect of nanotoxicity [146].…”

Section: Considerations On the Toxicity Of Nanomaterials In Wound Dressingsmentioning

confidence: 99%

Nanomaterials in Skin Regeneration and Rejuvenation

Bellu

Medici

Coradduzza

et al. 2021

IJMS

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Skin is the external part of the human body; thus, it is exposed to outer stimuli leading to injuries and damage, due to being the tissue mostly affected by wounds and aging that compromise its protective function. The recent extension of the average lifespan raises the interest in products capable of counteracting skin related health conditions. However, the skin barrier is not easy to permeate and could be influenced by different factors. In the last decades an innovative pharmacotherapeutic approach has been possible thanks to the advent of nanomedicine. Nanodevices can represent an appropriate formulation to enhance the passive penetration, modulate drug solubility and increase the thermodynamic activity of drugs. Here, we summarize the recent nanotechnological approaches to maintain and replace skin homeostasis, with particular attention to nanomaterials applications on wound healing, regeneration and rejuvenation of skin tissue. The different nanomaterials as nanofibers, hydrogels, nanosuspensions, and nanoparticles are described and in particular we highlight their main chemical features that are useful in drug delivery and tissue regeneration.

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“…[ 217 ] Moreover, even in these organs Ag NPs can enter in specific cells such as renal tubular epithelial cells and hepatic cells. [ 218 ] In another interesting study, Ag NPs were compared with TiO 2 NPs for their possible disruption BBB model in vitro. It was noticed that Ag ions induced inflammatory cytokines and had less cell‐to‐cell permeability than Ag NPs.…”

Section: Nanomaterials‐based Modulation Of Blood Brain Barriermentioning

confidence: 99%

Nanomaterials‐Mediated Structural and Physiological Modulation of Blood Brain Barrier for Therapeutic Purposes

Ghouri

Saleem

Ren

et al. 2021

Adv Materials Inter

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Blood brain barrier (BBB) protects homeostasis and sensitive environment of brain from several toxic substances coming from the systemic circulation. This barrier along with those substances also prevents therapeutic chemicals to reach brain tissues for several brain diseases. BBB consists of a number of cell types and junctions that help maintain its intricate structure and physiology. To open BBB for therapeutic purposes, researchers are keen to explore the use of nanomaterials as therapeutic agents. Nanomaterials have unique physio‐chemical properties such as, increased surface area to mass ratio, superior adsorption capacity, and a wide variety of functionalization possibilities in contrast to bulk materials, making them sought‐after for research pertaining to brain delivery of therapeutic substances. Both organic and inorganic nanomaterials have been researched in this regard with numerous interesting functionalizations, and their toxicity and distribution profiles have been well assessed. Different pathways taken up by nanomaterials to cross BBB like adsorptive‐mediated transcytosis, inhibition of active efflux pumps, receptor‐mediated transport, and cell‐mediated endocytosis have also been investigated. This review summarizes the structural and physiological properties and the modulation techniques of BBB for delivery of adsorbed/functionalized nano delivery platforms and imaging nanomaterials across.

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In vivo percutaneous permeation of gold nanomaterials in consumer cosmetics: implication in dermal safety assessment of consumer nanoproducts

Cited by 20 publications

References 42 publications

Dermal Toxicity Influence of Gold Nanomaterials after Embedment in Cosmetics

Dermal Toxicity Influence of Gold Nanomaterials after Embedment in Cosmetics

Nanomaterials in Skin Regeneration and Rejuvenation

Nanomaterials‐Mediated Structural and Physiological Modulation of Blood Brain Barrier for Therapeutic Purposes

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