<i>In vivo</i> oral insulin delivery <i>via</i> covalent organic frameworks

Benyettou, Farah; Kaddour, Nawel; Prakasam, Thirumurugan; Das, Gourab; Sharma, Sudhir Kumar; Thomas, Sneha; Bekhti-Sari, Fadia; Whelan, Jamie; Alkhalifah, Mohammed; Khair, Mostafa; Traboulsi, Hussein; Pasricha, Renu; Jagannathan, Ramesh; Mokhtari-Soulimane, Nassima; Gándara, Felipe; Trabolsi, Ali

doi:10.1039/d0sc05328g

Cited by 50 publications

(50 citation statements)

References 98 publications

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“…Recently, Benyettou et al reported imine-linked COF nanoparticles that can be used for efficient in vivo oral insulin delivery. 240 Using a seeded growth method, 210,241,242 they prepared an imine-linked nCOF by condensing 2,6-diformylpyridine (DFP) with 4,4′,4′′-(1,3,5-triazine-2,4,6-triyl)trianiline (TTA) (denoted as TTA-DFP-nCOF 153 ), as shown in Fig. 11a.…”

Section: Biomedical Applications Of Popsmentioning

confidence: 99%

Emerging porous organic polymers for biomedical applications

et al. 2022

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Section: Biomedical Applications Of Popsmentioning

confidence: 99%

Emerging porous organic polymers for biomedical applications

et al. 2022

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“…High dose of oral PA is often associated with nausea, vomiting and diarrhoea. Most importantly, developments of oral PA delivery have been seriously hindered by the gastrointestinal (GI) tract challenge [ 4 ]. PA via individual oral is generally degraded under the harsh gastric environments thereby limiting its transport across the intestinal epithelium into the bloodstream.…”

Section: Introductionmentioning

confidence: 99%

A nanosized anionic MOF with rich thiadiazole groups for controlled oral drug delivery

Jiang

Cao

et al. 2022

Materials Today Bio

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Controlling the crystal size and surface chemistry of MOF materials, and understanding their multifunctional effect are of great significance for the biomedical applications of MOF systems. Herein, we designed and synthesized a new anionic MOF, ZJU-64-NSN, which features 1D channels decorated with highly polarized thiadiazole groups, and its crystal size could be systematically tuned from 200 μm to 300 nm through a green and simple approach. As a result, the optimal nanosized ZJU-64-NSN is found to enable an ultrafast loading of cationic drug procainamide (PA) (21.2 wt% within 1 min). Moreover, the undesirable chemical stability of PA@ZJU-64-NSN is greatly improved by the surface coating of polyethylene glycol (PEG) biopolymer. The final drug delivery system PEG/PA@ZJU-64-NSN is found to effectively prevent PA from premature release under the harsh stomach environments due to the intense host-guest interaction, and mainly release PA to the targeted intestinal surroundings. Such controlled drug delivery is proved to be triggered by endogenic Na + ions instead of H + ions, well revealed by the study on the dynamics behavior of drug release and UV–Vis absorption spectrum. Good biocompatibility of ZJU-64-NSN and PEG-coated ZJU-64-NSN has been fully demonstrated by MTT assay as well as confocal microscopy imaging.

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“…These advantages of MOFs have led to various applications including lithium-ion batteries, gas-vapor separation, gas storage, and catalysis (23)(24)(25). The MOF abilities, particularly its excellent trapping and releasing molecules of interest, are extremely advantageous for biological studies (26)(27)(28). Specifically, several essential biomolecules, including bulk metals (e.g., potassium, calcium, and magnesium), trace metals (e.g., zinc, iron, and manganese), amino acids, neurotransmitters, and even vitamins, can be stored and constantly released from the MOFs over a long period of time (28)(29)(30)(31)(32).…”

Section: Introductionmentioning

confidence: 99%

“…The MOF abilities, particularly its excellent trapping and releasing molecules of interest, are extremely advantageous for biological studies (26)(27)(28). Specifically, several essential biomolecules, including bulk metals (e.g., potassium, calcium, and magnesium), trace metals (e.g., zinc, iron, and manganese), amino acids, neurotransmitters, and even vitamins, can be stored and constantly released from the MOFs over a long period of time (28)(29)(30)(31)(32). Therefore, such biomolecule-embedded MOFs can be extremely useful for controlling stem cell fates, which partially replace the role of the surrounding 3D cellular microenvironment in vivo.…”

Section: Introductionmentioning

confidence: 99%

Single metal-organic framework–embedded nanopit arrays: A new way to control neural stem cell differentiation

et al. 2022

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Stable and continuous supply of essential biomolecules is critical to mimic in vivo microenvironments wherein spontaneous generation of various cell types occurs. Here, we report a new platform that enables highly efficient neuronal cell generation of neural stem cells using single metal-organic framework (MOF) nanoparticle–embedded nanopit arrays (SMENA). By optimizing the physical parameters of homogeneous periodic nanopatterns, each nanopit can confine single nMOFs (UiO-67) that are specifically designed for long-term storage and release of retinoic acid (RA). The SMENA platform successfully inhibited physical interaction with cells, which contributed to remarkable stability of the nMOF (RA⊂UiO-67) structure without inducing nanoparticle-mediated toxicity issues. Owing to the continuous and long-term supply of RA, the neural stem cells showed enhanced mRNA expressions of various neurogenesis-related activities. The developed SMENA platform can be applied to other stem cell sources and differentiation lineages and is therefore useful for various stem cell–based regenerative therapies.

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In vivo oral insulin delivery via covalent organic frameworks

Abstract: We report the successful use of a gastro-resistant covalent organic framework for in vivo oral delivery of insulin.

Cited by 50 publications

References 98 publications

Emerging porous organic polymers for biomedical applications

Emerging porous organic polymers for biomedical applications

A nanosized anionic MOF with rich thiadiazole groups for controlled oral drug delivery

Single metal-organic framework–embedded nanopit arrays: A new way to control neural stem cell differentiation

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