<i>In Vivo</i>
            confocal microscopy findings after COVID-19 infection

Mangan, Mehmet Serhat; Taş, Ayşe Yıldız; Yıldız, Mehmet Kamil; Yıldız, Elvin; Şahin, Afsun

doi:10.1080/09273948.2021.1966051

Cited by 7 publications

(7 citation statements)

References 14 publications

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“…Cheema et al 13 demonstrated corneal involvement, specifically pseudodendritis and subepithelial infiltrates, in a COVID-19 patient whose only clinical feature was keratoconjunctivitis. Similarly, Mangan et al 15 presented in vivo confocal microscopy findings of unilateral subepithelial stromal opacities following conjunctivitis in a COVID-19 patient. The use of confocal microscopy revealed irregular corneal epithelial cells with bright borders, activated dendritic cells in the subbasal epithelial area, a notable reduction in the subbasal corneal nerve plexus, and clusters of reflective cells in the anterior stroma.…”

Section: Discussionmentioning

confidence: 91%

“…In addition, corneal sensitivity may be decreased as a result of corneal nerve involvement during SARS-CoV-2 infection. 15 However, there is limited available data in the literature currently regarding corneal findings in patients with COVID-19.…”

Section: Discussionmentioning

confidence: 99%

“… 11 , 12 Similar to adenoviruses, an immune-mediated mechanism composed of corneal infiltrates is present during COVID-19 infection. 15 …”

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confidence: 99%

“… 16 In addition, corneal sensitivity could be decreased due to the corneal nerve involvement of SARS-CoV-2. 15 …”

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confidence: 99%

“…16 In addition, corneal sensitivity could be decreased due to the corneal nerve involvement of SARS-CoV-2. 15 However, there is limited data regarding retinal pathologies in COVID-19 patients, such as retinal hyper-reflective dots, microangiopathy, retinal vein occlusions, and atypical multifocal evanescent white dot syndrome. 12,14,17 There has been only one case report of orbital myositis in a COVID-19 patient.…”

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confidence: 99%

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Assessment of corneal endothelial cell morphology and anterior segment parameters in COVID-19

Ören

Ozkoyuncu

2022

Ophthalmol Eye Dis

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Background: The ocular manifestations of the 2019 novel coronavirus disease (COVID-19) vary from acute follicular, pseudomembranous, and hemorrhagic conjunctivitis to keratoconjunctivitis with subepithelial infiltrates and dendritic lesions. Similar to other respiratory viruses, such as adenoviruses, it is thought that COVID-19 may impact the cornea. However, its impact on the cornea and anterior segment parameters are currently poorly understood. Objective: This study aims to assess the corneal endothelial cell morphology and anterior segment parameters in patients who have recovered from COVID-19. Methods: In this cross-sectional study, the COVID-19 group comprised 34 patients who had been diagnosed with and recovered from COVID-19, while the control group comprised age- and sex-matched individuals without any systemic or ocular diseases. The endothelial cell density (ECD), coefficient of variation (CV) of cell area, hexagonal cell percentage (HEX), anterior chamber depth (ACD), central corneal thickness (CCT), horizontal anterior chamber diameter (HACD), iridocorneal angle (ICA), horizontal visible iris diameter (HVID), pupillary diameter (PD), and keratometry values (K1 and K2) were analyzed for each participant. The differences in each of these between the groups were analyzed using either an independent samples t test or a Mann–Whitney U test based on the normality of the data. Results: Regarding corneal endothelial cell morphology, the ECDs for the COVID-19 and control groups were 2278.50 ± 186.78 cells/mm2 and 2420.15 ± 222.25 cells/mm2, respectively ( p = 0.002). A significant increase was noted in CV values in the COVID-19 group compared with the control group ( p < 0.001). The HEX values for the COVID-19 and control groups were 56.26 ± 5.75 and 61.50 ± 3.63, respectively ( p < 0.001). Regarding the anterior segment parameters, no significant differences were observed between the groups ( p > 0.05). Conclusions: It was hypothesized that individuals who had recovered from COVID-19 would demonstrate a reduction in their endothelial functional preserves. A decrease in ECD and HEX and an increase in CV were observed in the individuals during their early post-recovery period from COVID-19.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

“… 11 , 12 Similar to adenoviruses, an immune-mediated mechanism composed of corneal infiltrates is present during COVID-19 infection. 15 …”

mentioning

confidence: 99%

“… 16 In addition, corneal sensitivity could be decreased due to the corneal nerve involvement of SARS-CoV-2. 15 …”

mentioning

confidence: 99%

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