<i>In vivo</i>comparison of wound healing and scar treatment effect between curcumin–oligochitosan nanoparticle complex and oligochitosan-coated curcumin-loaded-liposome

Nguyen, Minh-Hiep; Vu, Ngoc-Bich-Dao; Nguyen, Thi-Huynh-Nga; Le, Hoang Sinh; Le, Huu-Tu; Tran, Thi-Tam; Le, Xuan-Cuong; Le, Van-Toan; Nguyen, Thi-Thu; Bui, Chi‐Bao; Park, Huyn-Jin

doi:10.1080/02652048.2019.1612476

Cited by 21 publications

(25 citation statements)

References 34 publications

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“…Compared to Ternullo et al [10], the ex vivo release through full thickness human skin exhibited a more sustained release when the DLs were incorporated into a hydrogel, as expected. Recently, Nguyen and coauthors [43] reported improved wound healing when utilizing a curcumin-oligochitosan nanoparticle complex and oligochitosan-coated curcumin-loaded liposomes with a curcumin concentration of 100 µg/mL. The hydrogel prepared in the current study contains curcumin in a concentration of 135 µg/g and is therefore similar to the concentration used by Nguen et al (2019).…”

Section: Ex Vivo Curcumin Penetration From Dls-in-hydrogel Into Humanmentioning

confidence: 65%

Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound Dressing

et al. 2019

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A liposomes-in-hydrogel system as an advanced wound dressing for dermal delivery of curcumin was proposed for improved chronic wound therapy. Curcumin, a multitargeting poorly soluble active substance with known beneficial properties for improved wound healing, was incorporated in deformable liposomes to overcome its poor solubility. Chitosan hydrogel served as a vehicle providing superior wound healing properties. The novel system should assure sustained skin delivery of curcumin, and increase its retention at the skin site, utilizing both curcumin and chitosan to improve the therapy outcome. To optimize the properties of the formulation and determine the effect of the liposomal charge on the hydrogel properties, curcumin-containing deformable liposomes (DLs) with neutral (NDLs), cationic (CDLs), and anionic (ADLs) surface properties were incorporated in chitosan hydrogel. The charged DLs affected the hydrogel's hardness, cohesiveness, and adhesiveness. Importantly, the incorporation of DLs, regardless of their surface charge, in chitosan hydrogel did not decrease the system's bioadhesion to human skin. Stability testing revealed that the incorporation of CDLs in hydrogel preserved hydrogel´s bioadhesiveness to a higher degree than both NDLs and ADLs. In addition, CDLs-in-hydrogel enabled the most sustained skin penetration of curcumin. The proposed formulation should be further evaluated in a chronic wound model.Curcumin has been proposed as one of the most promising [5]. Moreover, curcumin is a molecule able to active multiple pathways, contributing to improved wound healing [6]. The antioxidant, anti-inflammatory, and anti-bacterial properties of this pleiotropic molecule need to be more utilized [7,8]. Although curcumin is a very promising molecule to be included in wound dressings, its hydrophobicity, extensive metabolism, and limited skin penetration often hamper its wider use [9]. We have recently proven that curcumin, a multitargeting active substance, exhibits superior anti-inflammatory properties when incorporated in tailored deformable liposomes [10]. In this work, we went a step further in the development of curcumin-based wound dressings and combined the beneficial properties of curcumin as an active moiety and chitosan hydrogel as a superior vehicle to form a bioactive wound dressing targeting the treatment of chronic wounds.An ideal dressing should assure an enhanced therapeutic outcome and reduction of pain accompanied with wound dressing changes [11]. Among the possible material to be used in the manufacturing of bioactive dressings, natural polymer-based wound dressings, such as hydrogels, represent promising advanced delivery systems with a low risk of toxicity and side effects due to their biodegradability and biocompatibility [12,13]. Hydrogels mimic the biochemical, biomechanical, and structural features of the extracellular matrix (ECM), serving as superior matrices for wound treatment [13,14]. Hydrogels additionally possess good bioadhesiveness that can contribute to a prolonged retention...

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Section: Ex Vivo Curcumin Penetration From Dls-in-hydrogel Into Humanmentioning

confidence: 65%

Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound Dressing

et al. 2019

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“…In order to overcome these problems, the application of drug delivery systems, which are well known as the method or process of transporting drugs or bioactive compounds to achieve the medicinal effects in humans, is very attractive especially in the pharmaceutical field of study [ 1 , 2 ]. Currently, many kinds of drug delivery systems have been developed by the encapsulation of drugs or bioactive compounds in various carriers such as liposomes [ 3 , 4 ], nanoemulsions [ 5 ], nanostructured lipid carriers [ 6 , 7 ] and micelles [ 8 ], aiming to increase drug bioavailability, control the drug release rate at the target organ and improve the safety and stability of the delivery systems themselves [ 1 , 9 , 10 ]. Among these carriers, liposomes, which are long circulating macromolecular carriers, have become the most interesting carriers because of their potential to deliver both hydrophilic and hydrophobic substances to cell membranes [ 2 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Post-Processing Techniques for the Improvement of Liposome Stability

Chuesiang

Shin

et al. 2021

Pharmaceutics

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Liposomes have been utilized as a drug delivery system to increase the bioavailability of drugs and to control the rate of drug release at the target site of action. However, the occurrence of self-aggregation, coalescence, flocculation and the precipitation of aqueous liposomes during formulation or storage can cause degradation of the vesicle structure, leading to the decomposition of liposomes. To increase the stability of liposomes, post-processing techniques have been applied as an additional process to liposomes after formulation to remove water and generate dry liposome particles with a higher stability and greater accessibility for drug administration in comparison with aqueous liposomes. This review covers the effect of these techniques including freeze drying, spray drying and spray freeze drying on the stability, physicochemical properties and drug encapsulation efficiency of dry liposomes. The parameters affecting the properties of liposomes during the drying process are also highlighted in this review. In addition, the impact of using a protective agent to overcome such limitations of each process is thoroughly discussed through various studies.

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“…In animal models, daily curcumin topical application accelerated wound healing in irradiated mini-pigs, and the application of chrysin-curcumin-loaded nanofibers reduced the levels of IL-6, MMP-2, TIMP-1, TIMP-2, and iNOS gene expression in male rats, resulting in the acceleration of the healing process of surgical wounds [28,88]. Transdermally applied curcumin on surgical wounds on rats produced marked inhibition of H 2 O 2 -induced damage to keratinocytes and fibroblasts, while application of curcumin-oligochitosan nanoparticle complex or with application of oligochitosan coated curcumin-loaded-liposomes resulted in faster healing of surgical wounds in mice compared with controls [29,30]. In a diabetic rat model, wounds treated with curcumin showed an accelerated reepithelization rate compared with untreated controls [125].…”

Section: Introductionmentioning

confidence: 99%

“…As mentioned above, topical application of curcumin seems to have more pronounced effects on wound healing compared to its oral administration in the treatment of wounds, owing to higher accessibility of the drug at the wound site [94,125,126,127]. Many new formulations of curcumin have been developed in order to achieve better topical application at the wound site, such as chitosan-alginate sponges, curcumin-loaded polymeric bandages, alginate foams, collagen films, and nano-emulsion and hydrogel [26,27,28,29,30,31]. The incorporation into these formulations resulted in increased curcumin bioactivity, although no formulation showed a significant difference in its effect compared to the others.…”

Section: Introductionmentioning

confidence: 99%

“…The incorporation into these formulations resulted in increased curcumin bioactivity, although no formulation showed a significant difference in its effect compared to the others. However, formulation as nanoparticles seems to be of special interest, as it increases curcumin bioavailability and half-life and enhances its water dispersibility [27,30,31,32]. Further studies comparing nanoparticles with other formulations are needed in order to confirm these observations.…”

Section: Introductionmentioning

confidence: 99%

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Potential of Curcumin in Skin Disorders

et al. 2019

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Curcumin is a compound isolated from turmeric, a plant known for its medicinal use. Recently, there is a growing interest in the medical community in identifying novel, low-cost, safe molecules that may be used in the treatment of inflammatory and neoplastic diseases. An increasing amount of evidence suggests that curcumin may represent an effective agent in the treatment of several skin conditions. We examined the most relevant in vitro and in vivo studies published to date regarding the use of curcumin in inflammatory, neoplastic, and infectious skin diseases, providing information on its bioavailability and safety profile. Moreover, we performed a computational analysis about curcumin’s interaction towards the major enzymatic targets identified in the literature. Our results suggest that curcumin may represent a low-cost, well-tolerated, effective agent in the treatment of skin diseases. However, bypass of limitations of its in vivo use (low oral bioavailability, metabolism) is essential in order to conduct larger clinical trials that could confirm these observations. The possible use of curcumin in combination with traditional drugs and the formulations of novel delivery systems represent a very promising field for future applicative research.

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In vivocomparison of wound healing and scar treatment effect between curcumin–oligochitosan nanoparticle complex and oligochitosan-coated curcumin-loaded-liposome

Cited by 21 publications

References 34 publications

Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound Dressing

Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound Dressing

Post-Processing Techniques for the Improvement of Liposome Stability

Potential of Curcumin in Skin Disorders

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