<i>In vivo</i> bioavailability of polyphenols from grape by‐product extracts, and effect on lipemia of normocholesterolemic Wistar rats

Olivero-David, Raúl; Ruiz-Roso, María Belén; Caporaso, Nicola; Pérez‐Olleros, Lourdes; Heras, Natalia de las; Lahera, Vicente; Ruiz‐Roso, Baltasar

doi:10.1002/jsfa.9100

Cited by 15 publications

(13 citation statements)

References 51 publications

(119 reference statements)

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“…Furthermore, EGCG was shown to increase faecal bile acid excretion and significantly increase levels of CYP7A1. Modifications of bile acid and steroid excretion were further reported for a number of polyphenol-rich feedstocks, including apples [93,94], grapes [93,95,96], red beets [93], asparagus roots [97], and peanut skins [98]. Similar physiological outcomes were also described for extracts from black bean seed coats rich in flavonoids and saponins, indicating synergistic effects of these phytochemicals [99].…”

Section: Interactions Between Bile Acids and Phytochemicalsmentioning

confidence: 58%

Mechanisms of Interactions between Bile Acids and Plant Compounds—A Review

Naumann

Haller

Eisner

et al. 2020

IJMS

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Plant compounds are described to interact with bile acids during small intestinal digestion. This review will summarise mechanisms of interaction between bile acids and plant compounds, challenges in in vivo and in vitro analyses, and possible consequences on health. The main mechanisms of interaction assume that increased viscosity during digestion results in reduced micellar mobility of bile acids, or that bile acids and plant compounds are associated or complexed at the molecular level. Increasing viscosity during digestion due to specific dietary fibres is considered a central reason for bile acid retention. Furthermore, hydrophobic interactions are proposed to contribute to bile acid retention in the small intestine. Although frequently hypothesised, no mechanism of permanent binding of bile acids by dietary fibres or indigestible protein fractions has yet been demonstrated. Otherwise, various polyphenolic structures were recently associated with reduced micellar solubility and modification of steroid and bile acid excretion but underlying molecular mechanisms of interaction are not yet fully understood. Therefore, future research activities need to consider the complex composition and cell-wall structures as influenced by processing when investigating bile acid interactions. Furthermore, influences of bile acid interactions on gut microbiota need to be addressed to clarify their role in bile acid metabolism.

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Section: Interactions Between Bile Acids and Phytochemicalsmentioning

confidence: 58%

Mechanisms of Interactions between Bile Acids and Plant Compounds—A Review

Naumann

Haller

Eisner

et al. 2020

IJMS

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“…Studies are needed to compare individual with multiple polyphenols, determine the effectiveness of polyphenols as purified molecules relative to polyphenols in the native state in foods, and discover if other compounds in foods are also important in the activity of polyphenols. The different components of lipid profiles such as total cholesterol levels, HDL-C concentration [ 166 ], lipid peroxidation [ 167 ], triglycerides and LDL-C [ 168 ], that are affected by polyphenols, and the specific improvements of vascular function and cardiovascular risk factors induced by these compounds also needs to be studied further.…”

Section: Lipoproteins: Classes and Functionsmentioning

confidence: 99%

Current Therapies Focused on High-Density Lipoproteins Associated with Cardiovascular Disease

et al. 2018

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High-density lipoproteins (HDL) comprise a heterogeneous family of lipoprotein particles divided into subclasses that are determined by density, size and surface charge as well as protein composition. Epidemiological studies have suggested an inverse correlation between High-density lipoprotein-cholesterol (HDL-C) levels and the risk of cardiovascular diseases and atherosclerosis. HDLs promote reverse cholesterol transport (RCT) and have several atheroprotective functions such as anti-inflammation, anti-thrombosis, and anti-oxidation. HDLs are considered to be atheroprotective because they are associated in serum with paraoxonases (PONs) which protect HDL from oxidation. Polyphenol consumption reduces the risk of chronic diseases in humans. Polyphenols increase the binding of HDL to PON1, increasing the catalytic activity of PON1. This review summarizes the evidence currently available regarding pharmacological and alternative treatments aimed at improving the functionality of HDL-C. Information on the effectiveness of the treatments has contributed to the understanding of the molecular mechanisms that regulate plasma levels of HDL-C, thereby promoting the development of more effective treatment of cardiovascular diseases. For that purpose, Scopus and Medline databases were searched to identify the publications investigating the impact of current therapies focused on high-density lipoproteins.

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“…In recent years, the use of bio‐waste as a raw material both in scientific and industrial areas has gained huge interest. Agro‐food waste is often high in valuable compounds such as bioactive molecules useful in the preparation of dietary supplements and pharmaceuticals products …”

Section: Introductionmentioning

confidence: 99%

“…Agro-food waste is often high in valuable compounds such as bioactive molecules useful in the preparation of dietary supplements and pharmaceuticals products. [1][2][3] Sweet cherry (Prunus avium L.) is one of the most popular springsummer fruits, characterised by attractive appearance, firmness, high nutritional value and delicious taste. Sweet cherries are known as a good source of natural bioactive compounds with beneficial health effect.…”

Section: Introductionmentioning

confidence: 99%

New technological approaches for recovering bioactive food constituents from sweet cherry (Prunus avium L.) stems

Nastić

Lozano-Sánchez²,

Borrás-Linares³

et al. 2019

Phytochemical Analysis

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Introduction In recent years, an increasing interest in biological properties of sweet cherry (Prunus avium L.) stems has resulted in increased attention for advanced extraction techniques and their optimisation. Objectives In the present study chemical profiles of P. avium stems extracts obtained by selected emerging technologies, such as pressurised liquid extraction (PLE) and supercritical fluid extraction (SFE), under different experimental conditions were compared. Material and Methods All SFEs were carried out at 40°C in a dynamic mode with different solvent combinations (CO2 plus ethanol at 7 and 15%) and pressures (150 and 300 bar). The PLE experiments were performed in a static mode for all tested combinations of extraction solvent (ethanol–water from 0% to 100%) at temperatures ranging from 40 to 200°C. A complete analytical characterisation of cherry stem extracts was performed by high‐performance liquid chromatography coupled to electrospray ionisation quadrupole time‐of‐flight mass spectrometry (HPLC‐ESI‐QTOF‐MS). Results PLE showed to be more efficient than SFE removing a wide variety of compounds with different polarities being phenols the most abundant, whereas SFE resulted in a higher amount of fatty acids and derivatives. Chemical characterisation of the extracts was carried out by HPLC‐ESI‐QTOF‐MS yielding in total 42 identified compounds, among which 22 compounds were identified in P. avium stems for the first time. Conclusion These results point out the possibility of sweet cherry stem extracts to be incorporated in formulations manufactured by food and pharmaceutical industry. Also, these new thermal and high‐pressure industrial technologies proved to be promising candidates in the valorisation of sweet cherry by‐product.

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In vivo bioavailability of polyphenols from grape by‐product extracts, and effect on lipemia of normocholesterolemic Wistar rats

Abstract: Grape extract polyphenols are partially bioavailable and showed improvement in lipid metabolism. Thus, the results suggest that GE is promising as a functional ingredient in the prevention of hypercholesterolemia. © 2018 Society of Chemical Industry.

Cited by 15 publications

References 51 publications

Mechanisms of Interactions between Bile Acids and Plant Compounds—A Review

Mechanisms of Interactions between Bile Acids and Plant Compounds—A Review

Current Therapies Focused on High-Density Lipoproteins Associated with Cardiovascular Disease

New technological approaches for recovering bioactive food constituents from sweet cherry (Prunus avium L.) stems

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