In vivo and in vitro antioxidant activity of ghrelin: Attenuation of gastric ischemic injury in the rat

Abstract

These results provide evidence that peripherally administered ghrelin protects against gastric I/R injury. We also demonstrated that this protection is possibly accomplished through the antioxidant activity of ghrelin observed in vivo and in vitro.

Ghrelin, Nitrite and Paraoxonase/Arylesterase Concentrations in Cement Plant Workers

“…Based on job descriptions, the exposed subjects are more physically active in their occupation than the control subjects. Ghrelin not only fulfills a hormonal function in the body, but also is an endogenous antioxidant (37). Therefore, ghrelin may have been used up by the body in order to eliminate the inflammation (18) and oxidative stress caused by physical activity and cement dust, and this may have caused a decline in the amount of ghrelin.…”

Ghrelin Gene Products in Acute and Chronic Inflammation

“…Many mechanisms have been advocated, including nutritional factors, functional responses to anorexia, malabsorption, and chronic inflammation. The role of higher ghrelin levels as a functional response to protect gut cells is supported by evidence that ghrelin administration protects against ischemia/ reperfusion by reducing ulceration, tissue congestion, cellular infiltration, and vascular permeability (El Eter et al 2007;Wu et al 2009). In particular, ghrelin inhibits reactive oxygen species generation by human polymorphonuclear cells in a dose-dependent manner (El Eter et al 2007).…”

“…The role of higher ghrelin levels as a functional response to protect gut cells is supported by evidence that ghrelin administration protects against ischemia/ reperfusion by reducing ulceration, tissue congestion, cellular infiltration, and vascular permeability (El Eter et al 2007;Wu et al 2009). In particular, ghrelin inhibits reactive oxygen species generation by human polymorphonuclear cells in a dose-dependent manner (El Eter et al 2007). Interestingly, ghrelin administration is followed by an increased activity of stomach catalase, superoxide dismutase, glutathione reductase, and glutathione peroxidase in newborn streptozotocin-induced diabetic rats (Coskun et al 2013).…”

Ghrelin Improves Antioxidant Defense in Blood and Brain in Normobaric Hypoxia in Adult Male Rats

“…[19][20][21][22] Antioxidant properties of ghrelin have also been demonstrated in recent studies. [23][24][25] Therefore, the aim of this study was to evaluate the effects of ghrelin on the blood levels of MDA and TAC and brain levels of MDA, SOD, GPx and CAT in the normobaric systemic hypoxia situation in rats.…”