Ghrelin Improves Antioxidant Defense in Blood and Brain in Normobaric Hypoxia in Adult Male Rats

Omrani, Hasan; Alipour, Mohammad Reza; Mohaddes, Gisou

doi:10.15171/apb.2015.039

Cited by 19 publications

(21 citation statements)

References 45 publications

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“…This finding is consistent with results of Omrani, Alipour, and Mohaddes (2015). Increased motility and viability of spermatozoa, in turn, would increase the fertility rate.…”

Section: Discussionsupporting

confidence: 92%

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Effect of ghrelin on total antioxidant capacity, lipid peroxidation, sperm parameters and fertility in mice against oxidative damage caused by cyclophosphamide

et al. 2017

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Cyclophosphamide is a drug used for chemotherapy and as an immune-suppressive in the organ transplantation. Despite its many clinical implications in the treatment of cancers, this drug has toxic effects on the reproductive system. This study aimed to evaluate the effect of ghrelin against the damages caused by cyclophosphamide. In this experimental study, 40 male mice were randomly divided into four groups: (i) control; (ii) cyclophosphamide; (iii) cyclophosphamide + ghrelin; and (iv) ghrelin. Cyclophosphamide (100 mg/kg body weight), once a week, and ghrelin (80 μg/kg body weight), daily, were administered intraperitoneally for 5 weeks. After 5 weeks, the epididymides were removed and the lipid peroxidation, total antioxidant capacity and sperm parameters were examined. The fertility rate was evaluated by performance in vitro fertilisation. In the mice exposed to cyclophosphamide, the number of spermatozoa and viability, as well as total antioxidant capacity, decreased significantly (p < .05). The increase in the abnormal sperm and MDA levels was observed (p < .05). In addition, the fertility rate decreased in this group, while the use of ghrelin significantly improved the above disorders in the treatment group (p < .05). The findings of this study showed that ghrelin attenuates negative effects caused by cyclophosphamide in the sperm parameters and enhances the fertility.

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“…This finding is consistent with results of Omrani, Alipour, and Mohaddes (2015). Increased motility and viability of spermatozoa, in turn, would increase the fertility rate.…”

Section: Discussionsupporting

confidence: 92%

“…Moreover, treating the mice with ghrelin significantly increased the TAC. This finding is consistent with results of Omrani, Alipour, and Mohaddes (2015). They have also stated that ghrelin can increase serum antioxidant capacity in rats under hypoxia (Omrani et al, 2015).…”

Section: Discussionsupporting

confidence: 90%

Effect of ghrelin on total antioxidant capacity, lipid peroxidation, sperm parameters and fertility in mice against oxidative damage caused by cyclophosphamide

et al. 2017

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“…Oxygen is a vital element for most organisms and is necessary for normal redox reactions in the cell. Also, oxygen can be a source of ROS formation in cells 17 . It has been shown that both low (hypoxia) and high (hyperoxia) concentration of oxygen can promote oxidative damage and increase the risk of morbidity and mortality 18 .…”

Section: Discussionmentioning

confidence: 99%

“…Assessment of oxidative stress markers in the brain tissue of mice in three hypoxia models showed that edaravone reduced the level of oxidative stress in comparison with the control group. In fact, the hypoxia induced the ROS production and can cause oxidation of other cellular macromolecules such as protein 25,26 , DNA, and RNA 27,28 , lipid peroxidation 17,29,30 and neuronal dysfunction or death. Lipid peroxidation is one of the most critical indicators of oxidative stress that has harmful effects on cell or tissue and can lead to more free radical production via chain reaction, and finally, cell membrane disruption.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Edaravone Against Hypoxia-Induced Lethality in Male Swiss Albino Mice

Shaki

Mokhtaran

Shamshirian

et al. 2020

Preprint

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Edaravone is used for the treatment of acute cerebral infarction in Japan. However, nothing is known about the protective effects of this drug against hypoxia-induced lethality. In this study, the protective effects of edaravone against hypoxia-induced lethality and oxidative stress in mice were evaluated by three experimental models of hypoxia, which are asphyctic, haemic, and circulatory. Statistically significant protective activities were established in all tested models of hypoxia. Antihypoxic activities were especially pronounced in asphytic and circulatory hypoxia. The effect was dose-dependent. Edaravone, at 5 mg kg -1 , showed statistically significant activities respect to the control groups. It significantly prolonged the latency for death. At 2.5 mg kg -1 , it also prolonged survival time (26.08 ± 5.26 min), but this effect was not statistically significant from the control (P>0.05). On the other hand, edaravone significantly inhibited hypoxia-induced oxidative stress (lipid peroxidation and glutathione oxidation) in three models of hypoxia. In conclusion, the results obtained in this study showed that Edaravone has very good protective effects against the hypoxia in all tested models.

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“…Ghrelin may also be expressed in many tissues such as pancreas, pituitary, hypothalamus, lung, heart, and several tissues in the periphery (4)(5)(6) . Recent studies have suggested that ghrelin has wide physiological actions in the regulation of gastrointestinal, glucose homeostasis, immune functions, cardiovascular functions, antioxidant defense and bone formation (6)(7)(8) .…”

Section: Introductionmentioning

confidence: 99%

The Effect of Ghrelin Treatment on Cell Survival and Inflammation in Type 2 Diabetic Rat Liver

Coşkun¹,

Beydogan²,

Bolkent³

2017

Okmeydani Medical Journal

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, nuclear factor kappa B (NF-κB), peroxisome proliferatoractivated receptor gamma and proliferating cell nuclear antigen (PCNA) expressions were determined by immunohistochemical methods. Results: The number of MMP-2, MMP-9, NF-κB, PPAR-γ and IL-6 immunopositive cells increased in the diabetic rat liver as compared to control. The ghrelin treatment significantly reduced the numbers of MMP-2, MMP-9, NF-κB, PPAR-γ and IL-6 immunopositive cells in diabetic rat

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Ghrelin Improves Antioxidant Defense in Blood and Brain in Normobaric Hypoxia in Adult Male Rats

Cited by 19 publications

References 45 publications

Effect of ghrelin on total antioxidant capacity, lipid peroxidation, sperm parameters and fertility in mice against oxidative damage caused by cyclophosphamide

Effect of ghrelin on total antioxidant capacity, lipid peroxidation, sperm parameters and fertility in mice against oxidative damage caused by cyclophosphamide

Protective Effects of Edaravone Against Hypoxia-Induced Lethality in Male Swiss Albino Mice

The Effect of Ghrelin Treatment on Cell Survival and Inflammation in Type 2 Diabetic Rat Liver

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