<i>In vivo</i> and <i>in vitro</i> effects of curcumin on head and neck carcinoma: a systematic review

Borges, Gabriel Álvares; Rêgo, Daniela Fortunato; Assad, Daniele Xavier; Coletta, Ricardo D.; Canto, Graziela De Luca; Guerra, Eliete Neves Silva

doi:10.1111/jop.12455

Cited by 42 publications

(37 citation statements)

References 66 publications

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“…However, the activities of caspase-3 and caspase-9 were dramatically enhanced in CAR cells prior to treatment with cetuximab in combination with curcumin; or with exposure only to curcumin. The present results are also consistent with previous studies ( 26 , 31 ) showing that curcumin is effective against various types of cancer via intrinsic apoptotic function. Although curcumin possesses powerful biological activities, it does not reach the criteria of a good drug candidate because it lacks adequate water solubility and high bioavailability, and undergoes rapid in vivo metabolism ( 60 ).…”

Section: Discussionsupporting

confidence: 94%

“…The anticancer activities of curcumin are attributable to its anti-proliferative, anti-angiogenic, anti-metastatic, pro-apoptotic and autophagic characteristics ( 21 – 25 ). In vitro studies reported that curcumin inhibited cell proliferation in various oral cancer cell lines, including CAL 27, 1483, SCC-1, SCC-9, KB, SAS and SCC15 ( 26 ). Curcumin also suppressed EGFR expression and its downstream signaling molecules (NF-κB, JNK, p38 and ERK) which are vital for oral cancer pathogenesis ( 27 – 29 ).…”

Section: Introductionmentioning

confidence: 99%

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Synergistic inhibitory effects of cetuximab and curcumin on human cisplatin‑resistant oral cancer CAR cells through intrinsic apoptotic process

Chen

Chiang³

et al. 2018

Oncol Lett

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Cetuximab, an epidermal growth factor receptor (EGFR)-targeting monoclonal antibody (mAb), is a novel targeted therapy for the treatment of patients with oral cancer. Cetuximab can be used in combination with chemotherapeutic agents to prolong the overall survival rates of patients with oral cancer. Curcumin is a traditional Chinese medicine, and it has been demonstrated to have growth-inhibiting effects on oral cancer cells. However, information regarding the combination of cetuximab and curcumin in drug-resistant oral cancer cells is lacking, and its underlying mechanism remains unclear. The purpose of the present study was to explore the oral anticancer effects of cetuximab combined with curcumin on cisplatin-resistant oral cancer CAR cell apoptosis in vitro. The results demonstrated that combination treatment synergistically potentiated the effect of cetuximab and curcumin on the suppression of cell viability and induction of apoptosis in CAR cells. Cetuximab and curcumin combination induced apoptosis and dramatically increased caspase-3 and caspase-9 activities compared with singular treatment. Combination treatment also markedly suppressed the protein expression levels of EGFR and mitogen-activated protein kinases (MAPKs) signaling (phosphorylation of ERK, JNK and p38). The results demonstrated that co-treatment with cetuximab and curcumin exerts synergistic oral anticancer effects on CAR cells through the suppression of the EGFR signaling by regulation of the MAPK pathway.

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Synergistic inhibitory effects of cetuximab and curcumin on human cisplatin‑resistant oral cancer CAR cells through intrinsic apoptotic process

Chen

Chiang³

et al. 2018

Oncol Lett

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“…Considering the effects of turmeric and curcumin on the oral cavity, results were positive when it was applied as relief for tooth pain, cavity sealant, subgingival irrigator, and treatment for aphthous and potentially malignant lesions (Grover, Deswal, & Bhardwaj, 2015;Nagpal & Sood, 2013). Curcumin also inhibited tumor growth and cell viability and induced cytotoxicity, cell cycle arrest, and apoptosis in in vitro and in vivo head and neck carcinoma models, as observed by our research group in a previous systematic review (Borges et al, 2017). When tested in cutaneous radiation toxicity, curcumin was effective in reducing the severity of radiation dermatitis and moist desquamation in cancer patients (Palatty et al, 2014;Ryan et al, 2013;Vaughn, Branum, & Sivamani, 2016).…”

Section: Introductionsupporting

confidence: 71%

Effects of turmeric and curcumin on oral mucositis: A systematic review

Normando

Menêses

Toledo

et al. 2019

Phytotherapy Research

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The aim of this study was to evaluate the effects of turmeric and curcumin in the management of oral mucositis in cancer patients undergoing chemo and/or radiotherapy. The systematic review was reported according to the Preferred Reporting Items for Systematic reviews and Meta‐Analyses. The search was performed in the following database: Cochrane Library, LILACS, LIVIVO, PubMed, Scopus, and Web of Science. A gray literature search was undertaken using Google Scholar, Open Grey, and ProQuest. The methodology of included studies was evaluated by the Meta‐Analysis of Statistics Assessment and Review Instrument. After a two‐step selection process, four randomized and one nonrandomized clinical trials were included in the analysis. Two studies were categorized as low and three as moderate risk of bias. Turmeric/curcumin was applied topically as a gel or as a mouthwash. Patients treated with turmeric/curcumin experienced reduced grade of mucositis, pain, erythema intensity, and ulcerative area. Current evidence suggests that topical application of turmeric or curcumin is effective in controlling signs and symptoms of oral mucositis. Thus, further investigation is required to confirm the promising effect of turmeric and curcumin in oral inflammatory lesions.

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“…Combined treatment with curcumin and various anticancer drugs, such as 5‐FU and cisplatin, has been shown to improve efficacy and reduce toxicity . When utilized in HNSCC, the anticarcinogenic properties of curcumin include induction of apoptosis, cell cycle arrest, radiosensitivity, and chemotherapy sensitization . Dual treatment with both curcumin and metformin has been reported in hepatocellular carcinoma, pancreatic cancer cells, and breast cancer with the results suggesting synergistic effects.…”

Section: Introductionmentioning

confidence: 99%

“…[24][25][26] When utilized in HNSCC, the anticarcinogenic properties of curcumin include induction of apoptosis, cell cycle arrest, radiosensitivity, and chemotherapy sensitization. 27 Dual treatment with both curcumin and metformin has been reported in hepatocellular carcinoma, 28 pancreatic cancer cells, 29 and breast cancer 30 with the results suggesting synergistic effects. Combined treatment with metformin and curcumin is also thought to enhance chemoprevention properties, in vitro and in vivo, in oral cancer.…”

Section: Introductionmentioning

confidence: 99%

Antitumour effects of metformin and curcumin in human papillomavirus positive and negative head and neck cancer cells

Lindsay

Kostiuk

Conrad

et al. 2019

Molecular Carcinogenesis

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The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has significantly increased in recent decades due to human papillomavirus (HPV)‐mediated oncogenesis. Unfortunately, a growing number of HPV‐positive (+) OPSCC survivors are living with the irreversible side effects of treatment. The novel, well‐tolerated chemotherapeutics with improved side effect profiles are, therefore, in high demand. Metformin is one such drug, widely used as a first‐line oral agent in the treatment of type 2 diabetes mellitus. Curcumin is another well‐tolerated agent quickly gaining attention for its medicinal properties. Both metformin and curcumin have been shown to display anticancer properties. This study aimed to determine the antitumor effects of these agents, individually and combined, in HPV+ and HPV‐negative (−) head and neck squamous cell carcinoma (HNSCC) cell lines. This was achieved by assessing the efficacy of varying drug concentrations on the overall cell viability, proliferation, and expression of common HNSCC biomarkers. The results from protein and RNA expression data are highly variable, as expected, with multiple pathways being affected in cancer. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assays and immunofluorescence microscopy suggest that both agents are capable of slowing proliferation and inducing apoptosis. We conclude that curcumin and metformin display effective antitumor effects in both HPV+ and HPV− HNSCC cell lines. The curcumin effects appear more pronounced in the HPV− cell lines. Metformin appears to be more effective at reducing the overall cell numbers in HPV+ cell lines. Metformin and curcumin combined did not appear to have synergistic effects on the proliferation or apoptosis of the treated cell lines.

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In vivo and in vitro effects of curcumin on head and neck carcinoma: a systematic review

Abstract: This systematic review demonstrated that curcumin is effective on HNSCC cell proliferation and survival, reinforcing the currently available evidence that curcumin could be an adjuvant drug in HNSCC treatment.

Cited by 42 publications

References 66 publications

Synergistic inhibitory effects of cetuximab and curcumin on human cisplatin‑resistant oral cancer CAR cells through intrinsic apoptotic process

Synergistic inhibitory effects of cetuximab and curcumin on human cisplatin‑resistant oral cancer CAR cells through intrinsic apoptotic process

Effects of turmeric and curcumin on oral mucositis: A systematic review

Antitumour effects of metformin and curcumin in human papillomavirus positive and negative head and neck cancer cells

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