“…GDC, GAB-T, and SSADH have pH optima of 5.7, 8.9, and 9.0, respectively (Streeter and Thompson, 1972b), and therefore, the GABA shunt could act as a biochemical pH-stat in a way similar to that described for malic enzyme and PEP carboxylase (Davies, 1986). In addition, SSADH is believed to be inactivated under anaerobic conditions contributing to the accumulation of GABA (Satya Narayan and Nair, 1990).…”