<i>In vitro</i>study on the pulmonary cytotoxicity of amiodarone

Alsamri, Mohammed T.; Pramathan, Thachillath; Souid, Abdul‐Kader

doi:10.3109/15376516.2013.812170

Cited by 2 publications

(1 citation statement)

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“…Several mechanisms that may work in conjunction with each other and may involve the accumulation of iodine-rich amiodarone into pneumocytes have been suggested for amiodarone-induced pulmonary toxicity [3] [33] [34]. The first potential mechanism involves a direct toxic effect that disrupts cellular membranes through the activation of protein kinase C, release of toxic reactive oxygen species, decreases in glutathione, mitochondrial dysfunction, necrosis, and apoptosis.…”

Section: Lung Massesmentioning

confidence: 99%

Amiodarone Therapy for Cardiac Arrhythmias: Is It Associated with the Development of Cancers?

Mali¹,

Salzman²,

Vidaillet³

et al. 2014

WJCD

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Amiodarone is used worldwide to treat cardiac arrhythmias, as well as highly symptomatic cases of atrial fibrillation. With this expanded use, especially following its 1985 United States Food and Drug Administration approval, and its use as a long-term therapy in common practice, reports of cancers temporarily related to amiodarone have begun to increase. Animal studies, several clinical trials, numerous case reports, and a population-based cohort study have suggested that cancers may be associated with amiodarone use. This review focuses on the ever increasing evidence in the literature that suggests amiodarone therapy, especially with long-term use, may increase the potential risk of cancer development. It also expresses the need for more definitive studies to be conducted to provide clinicians with a clear answer to this important question.

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Section: Lung Massesmentioning

confidence: 99%