Selected Pneumotoxic Agents

Base-Mediated and Silver-Catalyzed Divergent Synthesis of Hydroxynaphthalenamides and Phosphorylated Dihydronaphthylamides from Enone-Oxazolones

“…Naphthalene and their analogs provide various platforms as organic building blocks and core structures for pharmaceutical drugs . Compounds containing the naphthalene skeleton have displayed a wide variety of important biological activities (Figure ).…”

“…Compounds containing the naphthalene skeleton have displayed a wide variety of important biological activities (Figure ). , For example, diospyrol is an anthelmintic natural product, nafcillin exhibited antibiotic activity, nafamostat is an anticoagulant while JNJ10311795, a phosphate-containing trinaphthalene compound, has been shown to possess potent inhibitory activity against neutrophil cathepsin G ( K i 38 nM) . Many approaches and synthetic methodologies for some naphthalene scaffolds have been reported .…”