<i>In vitro</i> study of biological activities of anthocyanin‐rich berry extracts on porcine intestinal epithelial cells

Kšonžeková, Petra; Mariychuk, Ruslan; Eliašová, Adriana; Mudroňová, Dagmar; Csank, Tomáš; Király, Ján; Marcinčáková, Dana; Pistl, J.; Tkáčiková, Ľudmila

doi:10.1002/jsfa.7181

Cited by 26 publications

(13 citation statements)

References 32 publications

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“…In other studies it was shown that cyanidin O -sambubioside is the main compound in elderberry extract [ 13 , 14 , 15 ]. Kšonžekowá et al [ 16 ] determined the total anthocyanin content in extract of elderberry as equal to 483.7 mg/g of DM, while other literature data indicate a 8.33–101.40 mg/g of DW range [ 17 ], which are either much higher or lower than the value determined in the present work (136.96 mg/g of DW). To a large degree it depends on the method of extraction and type of reagents used.…”

Section: Resultscontrasting

confidence: 77%

“…Antioxidant activity of elderberry extracts has been also confirmed in the current literature. The studies performed by Kšonžeková et al [ 16 ] confirmed the higher antioxidant status of elderberry extract, which is rich in cyanidin glycosides, compared to the activity of blueberry or bilberry extracts, and additionally indicated no cytotoxic effect on porcine intestinal epithelial cells. Studies by Bratu et al [ 37 ] inform, for example, that Sambucus nigra powder fruit extract in vitro has a very high antioxidant activity (quantified by a photoluminescence method), and no mutagenic effect at concentration below 0.1 g/dL, which makes it recommendable for application in food industry.…”

Section: Resultsmentioning

confidence: 94%

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A Comprehensive Study on the Biological Activity of Elderberry Extract and Cyanidin 3-O-Glucoside and Their Interactions with Membranes and Human Serum Albumin

et al. 2018

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In our research we used the extract from dietary supplement of elderberry (EE) and its dominant anthocyanin—cyanidin 3-O-glucoside (Cy 3-gluc). By interacting with a model membrane that reflects the main lipid composition of tumor membranes, the extract components, including Cy 3-gluc, caused an increase in packing order, mainly in the hydrophilic region of the membrane. It can thus be stated that EE caused a rigidifying effect, which is fundamental for understanding its anticancer and antioxidant activity. This study represents the first attempt to unravel the mechanism of interaction of elderberry extract with membranes. The results of the interaction with human serum albumin (HSA) proved that the studied substance quenches the fluorescence of HSA through a static mechanism in which the main interaction forces are Van der Waals and hydrogen bonding. The antioxidant activity of EE and Cy 3-gluc on liposomal membranes, antiradical properties and ability to inhibited the activity of the enzymes cyclooxygenase-1 and cyclooxygenase-2 were also demonstrated. Moreover, the anticancer activity of EE and Cy 3-gluc on human breast adenocarcinoma cell line were investigated. In addition, EE also exhibited the ability to form lipid aggregates in the form of liposomal capsules that can be applied as carriers of active biological substances, and the highest efficacy of EE encapsulation was obtained for multilayered liposome formulations.

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Section: Resultscontrasting

confidence: 77%

Section: Resultsmentioning

confidence: 94%

A Comprehensive Study on the Biological Activity of Elderberry Extract and Cyanidin 3-O-Glucoside and Their Interactions with Membranes and Human Serum Albumin

et al. 2018

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“…Elderberry displays a high concentration of compounds with antioxidative activity, especially anthocyanins, flavonoids and vitamins (Matejicek et al, 2015). Ksonzekova et al (2016) found that the chokeberry and elderberry extracts exhibit better antioxidant and anticytotoxic activ ities than blueberry or bilberry extracts with complex anthocyanin profile. Among the most common fruit and vegetables, elderberry is one of the richest in anthocyanins (Salamon et al, 2015) After preparation, the highest indicator of batter delamination was observed for the batter with no addition of fruit powders.…”

Section: Resultsmentioning

confidence: 99%

Freeze-dried elderberry and chokeberry as natural colorants for gluten-free wafer sheets

Różyło¹,

Wójcik²,

Dziki³

et al. 2019

Int. Agrophys.

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Freeze-dried elderberry and chokeberry were proposed as natural colorants for gluten-free wafers. In addition to colour, other physical and sensorial properties of wafer sheets were also evaluated. The elderberry powder was significantly darker (L* equal 37.61) than the chokeberry powder (L* equal 41.01), and it was characterized by a considerably lower a* value (4.21 in comparison with 12.32). These powdered fruits were added in the range from 0 to 5 %. A new indicator of wafer batter delamination was developed, which can also be proposed for other liquids. Significant and favourable changes were noted in the colour of both batter and wafers, with an increased content of fruits from 1 to 5%. Gluten-free wafers with a 5% addition of fruits were characterized by L*, a*, b* values, respectively, equalling 35.73, 6.05 and 3.24 for elderberry, and 39.74, 7.15 and 5.05 for chokeberry. Wafers with a 5% addition of chokeberry and elderberry, in comparison to control wafers, had significantly higher contents of minerals, including iron, potassium, calcium, magnesium and sodium. The freeze-dried elderberry powder, as compared to the chokeberry powder, was found to significantly increase the content of these minerals. In addition, the total flavonoids content was higher in the wafers containing elderberry. Freeze-dried chokeberry and elderberry can be proposed as natural colorants and valuable functional components for wafers. K e y w o r d s : natural colorant, elderberry, chokeberry, gluten-free, wafer

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“…The genus Vaccinium comprises a group of plants that includes up to 450 species; the fruits (berries) of many species are consumed by humans. The berries constitute a source of various bioactive phytonutrients, including phenolic compounds such as flavonoids, phenolic acids, lignans and polymeric tannins . Certain beneficial properties have been associated with the consumption of Vaccinium berries, such as antioxidant, antidiabetic, antihyperlipidemic, antiproliferative and neuroprotective activities …”

Section: Introductionmentioning

confidence: 99%

Vaccinium meridionale Swartz extracts and their addition in beef burgers as antioxidant ingredient

et al. 2017

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In vitro study of biological activities of anthocyanin‐rich berry extracts on porcine intestinal epithelial cells

Abstract: We found that the chokeberry and elderberry extracts rich in cyanidin glycosides possess better antioxidant and anticytotoxic activities in comparison to blueberry or bilberry extracts with complex anthocyanin profiles.

Cited by 26 publications

References 32 publications

A Comprehensive Study on the Biological Activity of Elderberry Extract and Cyanidin 3-O-Glucoside and Their Interactions with Membranes and Human Serum Albumin

A Comprehensive Study on the Biological Activity of Elderberry Extract and Cyanidin 3-O-Glucoside and Their Interactions with Membranes and Human Serum Albumin

Freeze-dried elderberry and chokeberry as natural colorants for gluten-free wafer sheets

Vaccinium meridionale Swartz extracts and their addition in beef burgers as antioxidant ingredient

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