In vitrointeraction of various antibiotic combinations recommended by Chinese consensus statement against carbapenems‐resistantPseudomonas aeruginosa

Abstract

Pseudomonas aeruginosa is related to nosocomial infections, and it tends to become resistant during or after antimicrobial treatment. The ability to develop carbapenems resistance makes it difficult to treat. P. aeruginosa infections are often associated with high mortality, morbidity and treatment costs. A group of Chinese experts drafted a consensus for treatment of extensively drug‐resistant Gram‐negative bacilli (XDR‐GNB) including extensively drug‐resistant P. aeruginosa (XDR‐PA). In this study, we studied the antibacterial activities of different antibiotic combinations against six carbapenems‐resistant P. aeruginosa (CRPA) strains in vitro, and the results indicated that the combination of ceftazidime with cefoperazone‐sulbatam was the best combination with excellent synergistic rate (100%). Besides, some combinations exhibited better effects than using antibiotics alone, reducing the MICs of both drugs significantly, such as ceftazidime/piperacillin‐tazobactam and ceftazidime/aztreonam etc. However, there are also some combinations that showed no additional or synergistic effects, suggesting that not all combinations recommended by the guideline have the same effect against resistant P. aeruginosa. Our study screened out some effective combinations against six CRPA strains which might help to prevent the spread of antibiotic resistance through improving antibiotic effectiveness. Significance and Impact of the Study This study measured the synergistic interactions between various antibiotics in vitro recommended by Chinese consensus statement against carbapenems‐resistant Pseudomonas aeruginosa. The results of this study provide valuable evidence that some combinations may be a promising option for clinical treatment.

Antibacterial and antibiofilm activities of fosfomycin combined with rifampin against carbapenem-resistant Pseudomonas aeruginosa

“…Our previous study has proved that among the combined therapies recommended by the Chinese consensus, CAZ + cefoperazone–sulbactam and AZT + FOS were the most effective combinations in the treatment of CRPA infections in vitro , with synergistic rates of 100 and 66%, respectively (Ma et al . 2019). In this study, we selected, FOS + RIF, a combination that guidelines have not been recommended for anti‐ PA treatment, to explore their potential value to CRPA and carbapenem‐susceptible PA strains.…”

Treatment of pulmonary infection of extensively drug-resistant Acinetobacter baumannii with intravenous colistin sulfate combined with atomization: a case report

“…The detection rate of multi-drug resistant bacteria represented by G-bacillus is rising rapidly, bringing great challenges to clinical anti-infection treatment (1). Extensive drug resistance refers to the phenomenon that bacteria are not sensitive to almost all classes of antibiotics except for classes 1-2 (mainly polymyxin and tigecycline) (2). Common strains that are extensively drug resistant (XDR), including Enterobacteriaceae bacteria, Acinetobacter baumannii, and Pseudomonas aeruginosa, and extensively drug-resistant Acinetobacter baumannii (XDRAB), are frequently seen in intensive care units (ICUs).…”