<i>In vitro</i>/<i>in vivo</i> correlation and modeling of emitted dose and lung deposition of inhaled salbutamol from metered dose inhalers with different types of spacers in noninvasively ventilated patients

Hussein, Raghda R. S.; Ali, Ahmed Mahmoud Abdelhaleem; Salem, Heba F.; Abdelrahman, Maha M.; Said, Amira S. A.; Abdelrahim, Mohamed

doi:10.3109/10837450.2015.1116567

Cited by 42 publications

(37 citation statements)

References 31 publications

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“…So, nebulizers, and nebulizers designs interation are significant model terms. The ''predicted R squared'' of 0.8558 and 0.9055 are in reasonable agreement with the ''adjusted R squared'' of 0.8697 and 0.9143 for inhalation and nebulizer chamber, respectively [21,22]. ''Adequate precision'' measures the signal-to-noise ratio.…”

Section: Discussionsupporting

confidence: 54%

Effect of Nebulizer Designs on Aerosol Delivery During Non-Invasive Mechanical Ventilation: A Modeling Study of In Vitro Data

et al. 2017

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Introduction: Nebulizers used to deliver aerosol during non-invasive mechanical ventilation (NIV) have many types, each type has many different designs. This study aimed to determine the effect of nebulizer deign on aerosol delivery in NIV. Methods: Different designs of jet nebulizer (JN) and vibrating mesh nebulizer (VMN) were tested by placing 1 ml of salbutamol in a nebulizer chamber operated in an in vitro NIV setting using a breathing simulator with adult settings (inhalation-exhalation ratio 1:3, 15 breaths/

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Section: Discussionsupporting

confidence: 54%

Effect of Nebulizer Designs on Aerosol Delivery During Non-Invasive Mechanical Ventilation: A Modeling Study of In Vitro Data

et al. 2017

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“…The choice of inhaled salbutamol dosage for different devices was in accordance with the previous literatures [17][18][19][20][21].…”

Section: Methodssupporting

confidence: 56%

“…Actuations of the sixteen puffs were synchronized with the start of patients' inspiration for better aerosol delivery [16,17].…”

Section: Methodsmentioning

confidence: 99%

Effects of Heat and Humidification on Aerosol Delivery during Auto-CPAP noninvasive Ventilation

Abdelrahim¹

2017

Arch Pulmonol Respir Care

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Objective: Although, the use of humidifi cation during non-invasive ventilation (NIV) is an important factor in decreasing nasal airway resistance and assuring patient's comfort and adherence; many in-vitro studies recommend switching off the humidifi er while delivering aerosol to NIV patients.The aim of the study was to in-vivo determine the effect of humidifi cation on salbutamol delivered via different inhalation devices to chronic obstructive pulmonary disease (COPD) patients using automatic continuous positive airway pressure (Auto-CPAP).Method: Aerosol delivery to NIV COPD patients by Aerogen Solo vibrating mesh nebuliser (VMN), Jet nebuliser (JET) and a metered dose inhaler (MDI) with AeroChamber MV spacer (AC) were compared with and without humidifi cation. Auto-CPAP was adjusted at non-invasive ventilation mode with the integrated heated humidifi er (IHH), as a source of humidity. The heater was set to the default setting 3, equivalent to 50ºC. Urine samples, 30 minutes and 24 hours post inhalation, as an index of the relative pulmonary and systemic bioavailability respectively, were provided by subjects and aliquots were retained for salbutamol analysis using solid phase extraction and high performance liquid chromatography (HPLC). Results:There was no signifi cant difference in the urinary excreted salbutamol post inhalation between the humidifi ed and dry conditions. However, there was a signifi cant difference between devices. The MDI with AC spacer had the highest percentage of 30 minutes urinary excreted salbutamol and JET had the lowest (p<0.01). VMN the highest percentage of 24 hours urinary excreted salbutamol and JET had the lowest but the difference was not signifi cant. Conclusion:Signifi cance of switching off humidity during aerosol delivered to ventilated patient was not as previously shown in in-vitro literatures. We recommend delivering aerosol medication to Auto-CPAP NIV patient using humidity without fear of lower delivery.

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“…The choice of inhaled salbutamol dosage was in accordance with previous literature. 16,18,[24][25][26][27][28][29][30][31][32][33][34][35][36] As recommended previously in studies that used single-limb NIV, 10,30 the nebulizers were placed proximal to the subject and distal to the fixed expiratory valve, as shown in Figure 1.…”

Section: Study Protocolmentioning

confidence: 99%

Performance of Large Spacer Versus Nebulizer T-Piece in Single-Limb Noninvasive Ventilation

et al. 2018

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The T-piece and large spacer were equally efficient for salbutamol delivery from the mesh nebulizer in patients with COPD and on single-limb noninvasive ventilation. Adding a preliminary bronchodilator dose by pMDI prenebulization showed a trend toward greater pulmonary bioavailability of nebulized salbutamol and may be worth considering to maximize delivery of salbutamol to patients who are severely ill.

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In vitro/in vivo correlation and modeling of emitted dose and lung deposition of inhaled salbutamol from metered dose inhalers with different types of spacers in noninvasively ventilated patients

Cited by 42 publications

References 31 publications

Effect of Nebulizer Designs on Aerosol Delivery During Non-Invasive Mechanical Ventilation: A Modeling Study of In Vitro Data

Effect of Nebulizer Designs on Aerosol Delivery During Non-Invasive Mechanical Ventilation: A Modeling Study of In Vitro Data

Effects of Heat and Humidification on Aerosol Delivery during Auto-CPAP noninvasive Ventilation

Performance of Large Spacer Versus Nebulizer T-Piece in Single-Limb Noninvasive Ventilation

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