In vitroextracellular recording and stimulation performance of nanoporous gold-modified multi-electrode arrays

Abstract

Electro-codeposition of Ag:Au alloy combined with chemical etching Ag is a low-cost process for fabricating nanoporous Au-modified MEA suitable for establishing the stimulus-response relationship of cultured neuronal networks.

PEDOT:PSS organic electrochemical transistor arrays for extracellular electrophysiological sensing of cardiac cells

“…In many applications the use of metal or metal-like materials is increasing the input impedance and hence decreasing the signal to noise ratio of the recordings. Several alternative materials and topographical methods were applied to counteract this technical limitation and to enable low noise recordings (Kim et al 2015;Regalia et al 2015).…”

Nanoporous Gold Biointerfaces: Modifying Nanostructure to Control Neural Cell Coverage and Enhance Electrophysiological Recording Performance

“…Few of these materials have reported an ability to effectively use nanostructure to selectively control the adhesion of neurons versus astrocytes . An emerging nanostructured material that has shown promise as a neural interface due to low impedance and a selective reduction in astrocytic surface coverage is nanoporous gold (np‐Au) . Np‐Au is composed of a network of gold pores and ligaments that are created by selective dissolution of silver from a gold‐silver alloy .…”

Nanoporous metals by alloy corrosion: Bioanalytical and biomedical applications

“…The first challenge of obtaining high-density electrode arrays with low electrical impedance has been addressed by employing traditional photolithography to fabricate NPG electrodes on glass and silicon substrates. 32,33 In electrophysiological recordings, the sensing is due to capacitive coupling between the ionic changes (created by neurons) and the electric double layer at the electrode-electrolyte interface. While reduction of electrical impedance due to electrodes with high effective surface area is commonly observed, this reduction was sustained even in biofouling solutions, likely by the aforementioned biofouling resilience (Figure 2c).…”

“…34 These are important findings that point to NPG's potential as a neural interface coating for enhanced electrode reliability and SNR for recording and electrical stimulation (Figure 4b). 32,33…”